Nebenschilddrüsen-Karzinom: Ein seltener Fall mit mandibulärem braunem Tumor

Abstract

Parathyroid carcinoma constitutes less than 1 % of primary hyperparathyroidism. The male to female ratio is approximately equal and the mean age at presentation is 40 years. In about half of the patients there is a palpable cervical mass, and serum calcium level is usually above 14 mg/dl. In a case report we present a 21-year-old man with a non-tender, non-mobile bulging mandibular mass. He suffered from fatigue, recent weight loss, hoarseness, polydipsia, polyuria, hematuria, recurrent renal stones and bouts of constipation and diarrhea. A mandibular biopsy confirmed brown tumor. Serum calcium level was 15.4 mg/dl. Cervical ultrasound revealed a hypoecho area suspicious of parathyroid adenoma. Parathyroid carcinoma was later confirmed and en bloc resection was performed. During a two-year follow up there has been no evidence of recurrence or hypercalcemia. This unique case of parathyroid carcinoma in conjunction with brown tumor is the second reported case worldwide.

Ultrasound features of malignancy in the preoperative diagnosis of parathyroid cancer: a retrospective analysis of parathyroid tumours larger than 15 mm

“…Observed changes relate to characteristic features of the gland itself and its presentation in the context of surrounding tissue. Full exploration of ultrasound features may require use of high-resolution techniques, colour Doppler ultrasound and consultation of Not described Not described Not described Not described Not described 1/1 Not described Tan [21] 1 Not described Not described Not described Not described Not described 1/1 Not described Bernstein [25] 1 1/1 Not described 1/1 Not described Not described Not described Not described Daly [15] 2 2/2 Not described 2/2 Not described Not described Not described Not described Ceriani [26] 1 Not described Not described Not described Not described 1/1 Not described Not described Rufener [27] 1 1/1 Not described Not described Not described Not described Not described Not described Harris [22] 1 Not described Not described Not described Not described Not described 1/1 0/1 Pahlavan [23] 1 1/1 Not described Not described Not described Not described Not described 0/1 Ito [24] 1 Not described Not described Not described Not described Not described Not described Not described Marcy [28] 1 0/1 1/1 1/1 Not described Not described 1/1 Not described Edmonson [ …”

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Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism

“…As a result of the subsequent treatment, both the child and the mother were cured. Since 0.74% of PHP cases are caused by carcinomas [24], which can also develop in young people [25], and since calcium levels are physiologically lower during pregnancy (which increases the risk of a potentially life-threatening hypercalcemic crisis after gestation), possible fatal consequences for the mother were prevented [8].…”

Sphenoid Brown Tumor Associated with a Parathyroid Carcinoma

“…When brown tumors are localized in the head and neck region they are usually found in the mandible [8–10]. Only four cases have been reported in the sphenoid bone, two cases due to primary hyperparathyroidism and two cases due to secondary hyperparathyroidism [11–14].…”