Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Hussain, Mazhar; Saeed, Muhammad; Babar, Muhammad Zafar Majeed; Atif, Moazzam Ali; Akhtar, Lubna

doi:10.1155/2017/7643628

Cited by 12 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The numbers of inflammatory cells in vessel walls are higher in hypertensive patients. As reflected in various guidelines, inflammatory biomarker levels usefully predict cardiovascular risks (18). A meta-analysis found that a higher NLR was associated with poorer functional outcomes and a higher risk of acute ischemic stroke (19).…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis found that a higher NLR was associated with poorer functional outcomes and a higher risk of acute ischemic stroke (19). An increased NLR was strongly and independently associated with HT severity in patients with untreated essential HT and was reported as prognostically significant regarding HT-associated complications such as heart failure and diseases of the CA, cerebral artery, and peripheral arteries (18).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension

Gökdemir

Gokdemir

Taş

2019

Turkish Journal of Emergency Medicine

View full text Add to dashboard Cite

ObjectivesWe aimed to investigate the role of inflammation parameters and platelet activation in geriatric patients with hypertension. Therefore, we compared the levels of those parameters in patients with hypertensive urgency and emergency. We also investigated the potential relationship between those parameters.MethodsNinety-six hypertensive (HT) patients (aged > 60) were included in the study in two groups: HT emergency (N = 48, group 1) and HT urgency (N = 48, group 2). Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and high-sensitive C reactive protein (hs-CRP) were compared between those groups. Optimum cut-off levels of each parameter were determined by the use of Receiver operating characteristic (ROC) curve analysis. Pearson correlation test was used to examine the relationship between variables.ResultsThe mean MPV and hs-CRP levels were significantly higher in patients with HT emergencies (both P < 0.001). Mean NLR was also significantly different between the two groups (P = 0.011). Pearson correlation analysis revealed a positive but weak correlation between the MPV and NLR (r = 0.245, P = 0.016), the hs-CRP level (r = 0.394, P < 0.001), and the WBC count (r = 0.362, P < 0.001).ConclusionIncreased platelet activity and inflammation are associated with the end organ failure. Levels of MPV and other inflammatory parameters may be useful in the management of geriatric patients with HT.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension

Gökdemir

Gokdemir

Taş

2019

Turkish Journal of Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…By contrast, the GEMINI trial showed that the use of carvedilol did not lead to substantial weight gain [ 111 ] and in fact was associated with beneficial effects such as improved insulin resistance [ 112 ], lipid profile [ 113 ] and a large reduction in microalbuminuria [ 114 ]. Moreover, the highly cardioselective, third-generation β blocker nevibolol demonstrated significant reduction in inflammation, improvement in lipid profile and blood glucose compared to conventional beta blockers [ 115 ].…”

Section: Pharmacotherapymentioning

confidence: 99%

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—A Condition Associated with Heightened Sympathetic Activation

Carnagarin

Tan

Adams

et al. 2021

IJMS

View full text Add to dashboard Cite

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease affecting a quarter of the global population and is often associated with adverse health outcomes. The increasing prevalence of MAFLD occurs in parallel to that of metabolic syndrome (MetS), which in fact plays a major role in driving the perturbations of cardiometabolic homeostasis. However, the mechanisms underpinning the pathogenesis of MAFLD are incompletely understood. Compelling evidence from animal and human studies suggest that heightened activation of the sympathetic nervous system is a key contributor to the development of MAFLD. Indeed, common treatment strategies for metabolic diseases such as diet and exercise to induce weight loss have been shown to exert their beneficial effects at least in part through the associated sympathetic inhibition. Furthermore, pharmacological and device-based approaches to reduce sympathetic activation have been demonstrated to improve the metabolic alterations frequently present in patients with obesity, MetSand diabetes. Currently available evidence, while still limited, suggests that sympathetic activation is of specific relevance in the pathogenesis of MAFLD and consequentially may offer an attractive therapeutic target to attenuate the adverse outcomes associated with MAFLD.

show abstract

“…Furthermore, the elevated neutrophillymphocyte ratio (NLR) is accepted as an inflammation biomarker for some vascular disease such as coronary heart disease, hypertension. Nebivolol has a strong impact on reducing NLR (30).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Nebivolol on Subarachnoid Hemorrhage-induced Vasospasm in the Rabbit

Güleç¹,

Izgi²

2019

BMB

View full text Add to dashboard Cite

Objective: This study aimed to investigate the vasorelaxation effect of nebivolol on vasospasm in the rabbit model of subarachnoid hemorrhage (SAH).Method: Single-hemorrhage model in the rabbit SAH was employed. SAH was induced in animals by cisterna manga injection of 4 mL autologous blood. Thirty-two animals were categorized into four groups: 1) control group (no SAH), 2) SAH group, 3) SAH + solvent infused group and 4) SAH + nebivolol treatment group. Forty-eight hours after SAHinduction, rabbits in group 3 and in 4 were received solvent or nebivolol, respectively. Nebivolol (0.073 mg/kg) was administered via the vertebral artery in 5 minutes. Digital subtraction angiography was performed at forty-nine hour following SAH-induced groups. The diameters of basilar arteries in four groups were measured at three points, and the average of the measurements was accepted as a consecutive result.Results: SAH-induced rats demonstrated severe vasospasm on day 2. Angiographic vasospasm was present in group 2 (SAH only), and in 3 (SAH plus solvent). Animals in group 4 (SAH plus nebivolol) and group 1 (control), respectively, demonstrated the largest diameters of basilar arteries. Animals treated with nebivolol has reached eighty-eight percent of the value in the control group 1. There was no statistical difference between the control group and SAH plus nebivolol treatment group (p>0.05). However, the difference was obtained between the groups SAH plus solvent and SAH plus nebivolol treatment (p<0.01). Conclusion:Vasospasm of the rat basilar arteries were significantly reversed by delivery of nebivolol directly into the constricted basilar artery. That drug used in cardiovascular disease may serve as a new treatment in the management of SAH patients.Amaç: Günümüzde, subraknoid kanama (SAK) sonrası ortaya çıkan vazospazm halen etkin olarak tedavi edilememektedir. β-1 reseptör antagonisti olan nebivololün, deneysel ve klinik araştırmalarda vazodilatasyon etkisi kanıtlanmıştır. Bu çalışmada, nebivololün SAK sonrası gelişen deneysel vazospazmın tedavisindeki etkinliği araştırılmıştır.Yöntem: Çalışmada, 32 adet Yeni Zelanda türü tavşan eşit olarak 4 gruba ayrıldı: 1) Kontrol grubu, 2) SAK grubu, 3) SAK + solvent verilen grup ve 4) SAK + nebivolol tedavi grubu. İkinci, 3. ve 4. gruptaki tavşanlarda tek kanamalı SAK modeli uygulandı. Tüm deneklere dijital anjiyografi yapıldı. Üçüncü ve 4. gruptaki tavşanlarda SAK sonrası 48. saatte transfemoral yöntemle Arteria vertebralis içine yerleştirilen kateterle 1 mL solvent (nebivololün içinde çözünmesinde kullanılan solüsyon) veya 1 mL hacim içinde 0.073 mg/kg dozda nebivolol infüzyonu yapıldı. SAH uygulanan 2., 3. ve 4. grup deneklere SAK uygulamasının 49. saatinde ve 1. gruptaki deneklere dijital anjiyografi yapıldı.Bulgular: Baziler arter ortalama çapları grup 1'de 0,64 mm, grup 2'de 0,33 mm, grup 3'te 0,37 mm ve grup 4'te 0,56 mm olarak saptandı. İkinci gruptaki deneklerde SAK sonrası 48. saatte yapılan dijital anjiyografi incelemesinde ağır vazospazm geliştirdiği saptandı. Baziler ar...

show abstract

Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Cited by 12 publications

References 26 publications

The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension

The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—A Condition Associated with Heightened Sympathetic Activation

The Effect of Nebivolol on Subarachnoid Hemorrhage-induced Vasospasm in the Rabbit

Contact Info

Product

Resources

About