Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients

Abstract

In hypertensive kidney transplant recipients, the effects of nebivolol vs metoprolol on nitric oxide (NO) blood level, estimated glomerular filtration rate (eGFR), and blood pressure (BP) have not been previously reported. In a 12-month prospective, randomized, open-label, active-comparator trial, hypertensive kidney transplant recipients were treated with nebivolol (n=15) or metoprolol (n=15 CI,) compared with the metoprolol group younger than 50 years, the metoprolol group 50 years and older, and the nebivolol group 50 years and older, respectively. The baseline to month 12 change in mean arterial BP, eGFR, and number of antihypertensive drug classes used was not significantly different between the treatment groups. In hypertensive kidney transplant recipients, nebivolol use in patients younger than 50 years increased blood NO.

Nebivolol in the treatment of arterial hypertension

“…First of all, the comparable BP‐lowering effect between nebivolol, previous BAAs and other antihypertensive agents was demonstrated in several studies including Stauffer et al, Santos et al and Duprez et al Nebivolol in antihypertensive combination therapy was likewise shown to have promising effects. The results of Grassi et al indicated that when using both office‐measured and holder BP monitoring, nebivolol is equal to AT 1 ‐R blockers regarding antihypertensive combination therapy with hydrochlorothiazide.…”

“…First of all, the comparable BP-lowering effect between nebivolol, previous BAAs and other antihypertensive agents was demonstrated in several studies including Stauffer et al, 80 Santos et al 81 85 that investigated the efficacy and tolerability of hypertensive treatment with byvalson and similarly found it to be very efficient. On this basis, nebivolol may be considered as first-line treatment in combination therapy.…”

Nebivolol in the treatment of systemic hypertension

“…Etkinlik çalışmalarında, nebivolol'ün kombinasyon tedavisi içerisinde de güçlü kan basıncı düşürücü etkiye sahip olduğu gözlenmiştir. [14][15][16] Bir araştırmada, hidroklorotiyazid ile kombine edildiğinde, nebivolol gerek klinik ölçümlerde gerekse ambulatuar ölçümlerde anjiyotensin reseptör blokerlerine (ARB) eşit ölçüde etkinlik göstermiştir. [17] Aynı şekilde nebivolol/valsartan kombinasyonu ile nebivolol'ün bu tür kombinasyonda da hayli etkin olduğu farkedilmiştir.…”