Nebulised Salbutamol With and Without Ipratropium Bromide in Acute Airflow Obstruction

O’Driscoll, B R; Horsley, MarkG.; Taylor, R.J.; Chambers, D. R.; Bernstein, A

doi:10.1016/s0140-6736(89)90126-8

Cited by 177 publications

(57 citation statements)

References 14 publications

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“…Most studies comparing short-acting beta-agonists with inhaled anticholinergic agents show no appreciable difference between the two in terms of effects on pulmonary function (156)(157)(158)(159). There may be fewer side effects with ipratropium than salbutamol (160).…”

Section: Bronchodilator Therapymentioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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Acute exacerbations of chronic bronchitis (AECB) account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality. This document represents a joint effort between respirologists, microbiologists, infectious disease specialists and family physicians to update the Canadian AECB guidelines published in 1994. Treatment recommendations are graded on the strength of evidence in the published literature where possible. The role for oral corticosteroid therapy in preventing treatment failures, speeding up recovery and delaying the time to next exacerbation is discussed. Risk factors for treatment failure were used to stratify patients into risk groups to help guide antibiotic treatment recommendations. The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested.

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Section: Bronchodilator Therapymentioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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“…9 Inhaled ␤ 2 -agonists and anticholinergic bronchodilators are the first-line treatment of bronchospasm during asthma or COPD exacerbation. 10,11 In patients with severe bronchospasm these agents are usually delivered via pneumatic nebulizer, with a gas flow of about 6 L/min. 12 Pneumatic nebulizer is as efficient as delivery via metered-dose inhaler, 13 and more efficient and better tolerated than intravenous administration.…”

Section: Introductionmentioning

confidence: 99%

Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device

et al. 2011

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BACKGROUND: A simple method for effective bronchodilator aerosol delivery while administering continuing continuous positive airway pressure (CPAP) would be useful in patients with severe bronchial obstruction. OBJECTIVE: To assess the effectiveness of bronchodilator aerosol delivery during CPAP generated by the Boussignac CPAP system and its optimal humidification system. METHODS: First we assessed the relationship between flow and pressure generated in the mask with the Boussignac CPAP system. Next we measured the inspired-gas humidity during CPAP, with several humidification strategies, in 9 healthy volunteers. We then measured the bronchodilator aerosol particle size during CPAP, with and without heat-and-moisture exchanger, in a bench study. Finally, in 7 patients with acute respiratory failure and airway obstruction, we measured work of breathing and gas exchange after a ␤ 2 -agonist bronchodilator aerosol (terbutaline) delivered during CPAP or via standard nebulization. RESULTS: Optimal humidity was obtained only with the heat-and-moisture exchanger or heated humidifier. The heat-and-moisture exchanger had no influence on bronchodilator aerosol particle size. Work of breathing decreased similarly after bronchodilator via either standard nebulization or CPAP, but P aO 2 increased significantly only after CPAP aerosol delivery. CONCLUSIONS: CPAP bronchodilator delivery decreases the work of breathing as effectively as does standard nebulization, but produces a greater oxygenation improvement in patients with airway obstruction. To optimize airway humidification, a heat-and-moisture exchanger could be used with the Boussignac CPAP system, without modifying aerosol delivery.

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“…). Оценка полу ченных результатов проводилась при сопоставлении данных с должными величинами, рассчитанные по формулам Европейского сообщества стали и угля [17].…”

Section: материалы и методыunclassified

Comparison of nebulised bronchodilators in acute exacerbation of chronic obstructive pulmonary disease

Авдеев¹,

Баймаканова²,

Зубаирова³

et al. 2012

Pulʹmonologiâ (Mosk.)

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Nebulised Salbutamol With and Without Ipratropium Bromide in Acute Airflow Obstruction

Cited by 177 publications

References 14 publications

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device

Comparison of nebulised bronchodilators in acute exacerbation of chronic obstructive pulmonary disease

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