Nebulized Bronchodilators Are Associated With Cardiac Dysfunction in Chronic Obstructive Pulmonary Disease

Shafuddin, Eskandarain; Cooray, Manisha; Tuffery, Christine; Hopping, Sandra; Sullivan, Glenda; Chang, Catherina L.; Hancox, Robert J.

doi:10.1378/chest.2223975

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“…Both cohorts excluded patients hospitalised for reasons other than exacerbations of COPD, other acute respiratory illness (such as asthma, bronchiectasis or interstitial lung disease) and primary presentations with acute coronary syndrome or heart failure. Additionally, cohort 2 excluded patients with clinically significant severe valvular heart disease, end‐stage renal disease, terminal malignancy and inability to attend follow‐up visits in view of its primary aim to study the time course of cardiac biomarkers during exacerbations of COPD . Both cohort studies received ethical approvals from New Zealand Health and Disability Ethics Committees (12/NTA/43 and LRS/12/06/019).…”

Section: Methodsmentioning

confidence: 99%

Comparing severity scores in exacerbations of chronic obstructive pulmonary disease

Shafuddin

Chang

Hancox

2018

Clinical Respiratory J

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Introduction Prognostic scores help identify patients at a high risk of mortality in exacerbations of chronic obstructive pulmonary disease (COPD). The Dyspnoea, Eosinopaenia, Consolidation, Acidaemia and atrial Fibrillation (DECAF) score has been reported to perform better than other severity scores in predicting mortality from exacerbations of COPD in studies including patients with pneumonia. Objective To compare the performance of DECAF with other prognostic scores: CURB‐65, CRB‐65 and BAP‐65, in predicting 30‐day mortality in patients hospitalised with exacerbations of COPD without pneumonia. Methods Data from hospital admission of 423 patients from two cohorts of patients with exacerbations of COPD without consolidation on chest radiographs were used to compile the CURB‐65, CRB‐65, BAP‐65 and DECAF scores. The performance of each prognostic score in predicting 30‐day mortality was studied using receiver operating curve analysis. Results Thirty‐one patients (7%) died within 30 days of hospital admission. One hundred patients (24%) did not have DECAF scores because of the incomplete laboratory data, while all 423 patients had the other scores available for analysis. All scores predicted mortality with similar areas under the receiver operating characteristic curve (CURB‐65 = 0.69, CRB‐65 = 0.64, BAP‐65 = 0.64, DECAF = 0.65, P = 0.186). Conclusion In patients hospitalised with exacerbations of COPD without pneumonia, simple clinical scores that rely on fewer laboratory measures perform at least as well as DECAF in predicting early mortality.

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Section: Methodsmentioning

confidence: 99%