2020
DOI: 10.1371/journal.pone.0237174
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Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

Abstract: Postoperative sore throat is one of the most common complications following endotracheal intubation. Nebulization therapy, a preferable and safety method of drug delivery, has been shown to be effective in postoperative sore throat prevention in many studies. However, the relative efficacy of various nebulized agents remains unknown. In this review, we aimed to quantify and rank order the efficacy of available nebulized agents for various postoperative sore throat-related outcomes. A comprehensive literature s… Show more

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Cited by 9 publications
(4 citation statements)
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“…Anaesthetist experience was not associated with the rate of sore throat, consistent with another study [21]. We think that tracheal intubation with smaller tubes is an easier intervention than others tested to reduce postoperative sore throat, such as drugs or laryngeal nerve block [22][23][24][25][26][27].…”
Section: Discussionsupporting
confidence: 85%
“…Anaesthetist experience was not associated with the rate of sore throat, consistent with another study [21]. We think that tracheal intubation with smaller tubes is an easier intervention than others tested to reduce postoperative sore throat, such as drugs or laryngeal nerve block [22][23][24][25][26][27].…”
Section: Discussionsupporting
confidence: 85%
“…4 The pharmacological methods include topical drug application over the ETT cuffs or filling the cuffs with drugs, using oral gargles, inhaled nebulization, and intravenous (IV) injections. [3][4][5][6][7] The drugs studied to reduce POST include steroids, [5][6][7] local anesthetics (LA), 8 benzydamine, 9 aspirin, 2 magnesium, 10 ketamine, 3,11 zinc, 12 and licorice gargle. 13 Eutectic mixture of LA (EMLA) is a 1:1 mixture of lidocaine 2.5% and prilocaine 2.5%, which has a melting point below room temperature.…”
Section: Glossarymentioning
confidence: 99%
“…The incidence of POST is correlated with age, sex, tracheal tube size, endotracheal tube cuff pressure and other factors [ 4 ]. Various methods have been applied to reduce the incidence and severity of POST, including IV administration of lidocaine or dexamethasone [ 5 , 6 ]; replacement of a double-lumen tube with an endobronchial blocker [ 7 ]; and prophylactic use of nebulised ketamine, magnesium, or corticosteroids [ 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%