Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

Zhou, Ting; Huang, Wan; Xu, Qian; Zhou, Xiao; Wang, Yue; Yue, Zhaohui; Song, Bin

doi:10.1186/s11671-020-03300-5

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…161 TiO 2 NPs were shown to cause endoplasmic reticulum (ER) stress, autophagy, inhibition of cell proliferation, disturbance of the microtubule dynamics, and membrane damage in SH-SY5Y cells. [153][154][155][156][157][158] Several in vivo studies investigated the neurotoxic effects of TiO 2 NPs on mouse hippocampus. However, one in vitro study explored the neurotoxic effects of TiO 2 NPs on mouse hippocampal neuronal HT22 cells.…”

Section: Neurotoxic Effects Of Tio 2 Nps In Vitro Modelsmentioning

confidence: 99%

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Zhang,

Song,

Gong

et al. 2023

IJN

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The increasing use of titanium dioxide nanoparticles (TiO 2 NPs) across various fields has led to a growing concern regarding their environmental contamination and inevitable human exposure. Consequently, significant research efforts have been directed toward understanding the effects of TiO 2 NPs on both humans and the environment. Notably, TiO 2 NPs exposure has been associated with multiple impairments of the nervous system. This review aims to provide an overview of the documented neurotoxic effects of TiO 2 NPs in different species and in vitro models. Following exposure, TiO 2 NPs can reach the brain, although the specific mechanism and quantity of particles that cross the blood-brain barrier (BBB) remain unclear. Exposure to TiO 2 NPs has been shown to induce oxidative stress, promote neuroinflammation, disrupt brain biochemistry, and ultimately impair neuronal function and structure. Subsequent neuronal damage may contribute to various behavioral disorders and play a significant role in the onset and progression of neurodevelopmental or neurodegenerative diseases. Moreover, the neurotoxic potential of TiO 2 NPs can be influenced by various factors, including exposure characteristics and the physicochemical properties of the TiO 2 NPs. However, a systematic comparison of the neurotoxic effects of TiO 2 NPs with different characteristics under various exposure conditions is still lacking. Additionally, our understanding of the underlying neurotoxic mechanisms exerted by TiO 2 NPs remains incomplete and fragmented. Given these knowledge gaps, it is imperative to further investigate the neurotoxic hazards and risks associated with exposure to TiO 2 NPs.

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Section: Neurotoxic Effects Of Tio 2 Nps In Vitro Modelsmentioning

confidence: 99%

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Zhang,

Song,

Gong

et al. 2023

IJN

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“…This may lead TiO 2 -NPs to be toxicologically potent than previously known. [52,[132][133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148][149] ZnO-NPs…”

Section: Mgo-npsmentioning

confidence: 99%

Metal Oxide Nanoparticles in Food Packaging and Their Influence on Human Health

Stuparu-Crețu

Braniște

Necula

et al. 2023

Foods

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It is a matter of common knowledge in the literature that engineered metal oxide nanoparticles have properties that are efficient for the design of innovative food/beverage packages. Although nanopackages have many benefits, there are circumstances when these materials are able to release nanoparticles into the food/beverage matrix. Once dispersed into food, engineered metal oxide nanoparticles travel through the gastrointestinal tract and subsequently enter human cells, where they display various behaviors influencing human health or wellbeing. This review article provides an insight into the antimicrobial mechanisms of metal oxide nanoparticles as essential for their benefits in food/beverage packaging and provides a discussion on the oral route of these nanoparticles from nanopackages to the human body. This contribution also highlights the potential toxicity of metal oxide nanoparticles for human health. The fact that only a small number of studies address the issue of food packaging based on engineered metal oxide nanoparticles should be particularly noted.

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“…Several in vivo and in vitro studies have demonstrated the neurotoxicity of TiO 2 NPs through programmed cell death processes, such as apoptosis, autophagy and necroptosis depending on the duration of exposure and the dose-dependence. Although low-dose exposure could not induce any acute neurotoxicity, chronic exposure to low dose TiO 2 NPs results in TiO 2 accumulation and might lead to dramatic changes in the brain [ 43 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Tio 2 Nps Hazard For Human Healthmentioning

confidence: 99%

TiO2 Nanoparticles and Their Effects on Eukaryotic Cells: A Double-Edged Sword

Gojznikar

Zdravković

Vidak

et al. 2022

IJMS

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Nanoparticulate TiO2 (TiO2 NPs) is a widely used material, whose potential toxicity towards eukaryotic cells has been addressed by multiple studies. TiO2 NPs are considered toxic due to their production of reactive oxygen species (ROS), which can, among others, lead to cellular damage, inflammatory responses, and differences in gene expression. TiO2 NPs exhibited toxicity in multiple organs in animals, generating potential health risks also in humans, such as developing tumors or progress of preexisting cancer processes. On the other hand, the capability of TiO2 NPs to induce cell death has found application in photodynamic therapy of cancers. In aquatic environments, much has been done in understanding the impact of TiO2 on bivalves, in which an effect on hemocytes, among others, is reported. Adversities are also reported from other aquatic organisms, including primary producers. These are affected also on land and though some potential benefit might exist when it comes to agricultural plants, TiO2 can also lead to cellular damage and should be considered when it comes to transfer along the food chain towards human consumers. In general, much work still needs to be done to unravel the delicate balance between beneficial and detrimental effects of TiO2 NPs on eukaryotic cells.

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Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

Cited by 8 publications

References 39 publications

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Metal Oxide Nanoparticles in Food Packaging and Their Influence on Human Health

TiO2 Nanoparticles and Their Effects on Eukaryotic Cells: A Double-Edged Sword

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