An early postnatal oxytocin treatment prevents social and learning deficits in adult mice deficient for Magel2, a gene involved in PWS and autism Magel2 tm1.1Mus oxytocin i.p. single injection, 2 mg c social recognition deficits n = 12-14, M adult 29 An early postnatal oxytocin treatment prevents social and learning deficits in adult mice deficient for Magel2, a gene involved in PWS and autism Magel2 tm1Stw MT-II i.p. single injection, 2.5 mg/kg d 24 h food intake n = 6, M 3-4 months 6 Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice Magel2 tm1Stw setmelanotide i.p. single injection (0.04, 0.1, 0.2 or 1 mg/kg) e food intake, EE, RER n = 6, M 2-3 months 34 Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist Magel2 tm1Stw sleeve gastrectomy surgery f weight, food intake, fat/lean mass, fasting glucose, glucose tolerance, counter-regulation n = 7-12, M 5-7 months, HFD 35 Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse Magel2 tm1Stw JD5037 or SLV319 i.p. daily 28 d, 3 mg/kg g weight, food intake, body comp, activity, metabolism n = 5-10, M and F 3-4 months, HFD or STD 36