2017
DOI: 10.18632/oncotarget.20999
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Necdin modulates leukemia-initiating cell quiescence and chemotherapy response

Abstract: Acute myeloid leukemia (AML) is a devastating illness which carries a very poor prognosis, with most patients living less than 18 months. Leukemia relapse may occur because current therapies eliminate proliferating leukemia cells but fail to eradicate quiescent leukemia-initiating cells (LICs) that can reinitiate the disease after a period of latency. While we demonstrated that p53 target gene Necdin maintains hematopoietic stem cell (HSC) quiescence, its roles in LIC quiescence and response to chemotherapy ar… Show more

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Cited by 2 publications
(1 citation statement)
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“…Relevant to hypotonia, necdin enhances myoblast survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1, in a study that used both tgMlcNec mice and Ndn tm1.1Mus mice 72 . Necdin regulates the quiescence and response to genotoxic stress of hematopoietic stem and progenitor cells, as demonstrated using Ndn tm2Stw mutant mice 73, 74, 75, 76, 77. Necdin also protects neurons against mitochondrial insults by promoting mitochondrial biogenesis, in a study that used the Ndn tm1Ky mice 78 .…”
Section: Main Textmentioning
confidence: 98%
“…Relevant to hypotonia, necdin enhances myoblast survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1, in a study that used both tgMlcNec mice and Ndn tm1.1Mus mice 72 . Necdin regulates the quiescence and response to genotoxic stress of hematopoietic stem and progenitor cells, as demonstrated using Ndn tm2Stw mutant mice 73, 74, 75, 76, 77. Necdin also protects neurons against mitochondrial insults by promoting mitochondrial biogenesis, in a study that used the Ndn tm1Ky mice 78 .…”
Section: Main Textmentioning
confidence: 98%