Necessity of Internal Monitoring for Nuclear Medicine Staff in a Large Specialized Chinese Hospital

Wang, Hongbo; Zhang, Qingzhao; Zhang, Zhen; Hou, Changsong; Li, Wenliang; Yang, Hui; Sun, Qiang

doi:10.3390/ijerph13040418

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…[ 18 ] Unlike other radiation specialties, nuclear medicine applications possess a high risk of contamination, which is a significant source of exposure. [ 19 ] We observed higher DNA damage with internal irradiation compared to external irradiation from Tc-99 m and F-18 sources in the present study. Radiation exposure and absorbed dose from internal contamination can induce greater DNA damage than external contamination.…”

Section: Discussionsupporting

confidence: 48%

Biological Effects Associated with Internal and External Contamination of Diagnostic Nuclear Medicine Sources

Nautiyal

Mondal

Goel

et al. 2021

Indian Journal of Nuclear Medicine

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Aim: In a Nuclear Medicine department, the risk of external and internal contamination in radiation workers is much higher than in other medical radiation facilities. The risk associated with both types of contaminations should be quantified to estimate the radiation dose received by the personal. Here, we designed an in vitro model to see the impact of internal and external contamination of F-18 and Technetium-99 m (Tc-99 m) on DNA damages. Methodology: Chinese hamster lung fibroblast V79 was used for all of the experiments. Irradiation was performed internally and externally (scenarios activity is mixed with the cell line [Internal] and activity kept at 1 cm distance from cell line [external]) using two different diagnostic radioactive sources (Tc-99 m and F-18) of known quantity 37 MBq. Total cumulated activity (MBq-min) was calculated up to one half-life of sources for both internal and external setups. An alkaline single gel electrophoresis technique (comet assay) was used for DNA damage analysis. Olive tail moment (OTM) was used to characterize DNA damage. Results: We have not observed any significant difference ( P > 0.05) in OTM between internal and external irradiation for cumulated activity presented before one half-life of both diagnostic isotopes. However, a significant difference in OTM was noted between internal and external irradiation for cumulated activity presented at one half-life of radioactive sources ( P < 0.05). DNA damage with internal exposure was found to be 17.28% higher for F-18 and 23% higher for Tc-99 m than external exposure at one half-life of radioactive sources. Overall, we noted greater DNA damage in F-18 as compared to Tc-99 m. Conclusions: Our in vitro study practically demonstrated that internal contamination is more hazardous than external exposure.

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Section: Discussionsupporting

confidence: 48%

Biological Effects Associated with Internal and External Contamination of Diagnostic Nuclear Medicine Sources

Nautiyal

Mondal

Goel

et al. 2021

Indian Journal of Nuclear Medicine

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“…Em outros países da América Latina e Caribe [16][17][18] , na América do Norte [19][20][21] , Europa [22][23][24] e Ásia 25,26 , a situação da monitoração interna em medicina nuclear é bastante semelhante à do Brasil. Em alguns países, assim como no Brasil, foram desenvolvidas metodologias de monitoração utilizando os recursos disponíveis nas próprias clínicas.…”

Section: Discussionunclassified

Avaliação das Exposições Ocupacionais Internas em Medicina Nuclear – Dificuldades e Alternativas

et al. 2019

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Profissionais que manipulam radiofármacos para fins de diagnóstico e terapia em medicina nuclear estão sujeitos à incorporação de radionuclídeos via inalação e ingestão. Os aspectos de proteção radiológica dessa prática são regulamentados pela Comissão Nacional de Energia Nuclear (CNEN), e a Agência Internacional de Energia Atômica (AIEA) recomenda a implantação de programas de monitoração ocupacional quando houver risco de doses efetivas anuais superiores a 1 mSv. O controle de incorporações de radionuclídeos pode ser realizado por meio de técnicas de dosimetria interna. Atualmente, no Brasil, não existem laboratórios suficientes capacitados a prestar serviços de monitoração interna para atender a toda a demanda caso essa exigência seja aplicada pela CNEN. Este artigo apresenta um panorama da situação atual no Brasil e as alternativas técnicas economicamente viáveis, a fim de tornar factível a implantação de programas rotineiros de monitoração interna de trabalhadores ocupacionalmente expostos a riscos significativos de exposição a radionuclídeos manipulados em medicina nuclear.

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“…The Chinese national standard GBZ 129-2016 Specifications for Individual Monitoring of Occupational Internal Exposure has been published since 2016 [ 5 ]. However, only about 30 institutes could perform internal monitoring now, so 131 I activity on the NM workers was not routinely monitored in China [ 6 ]. Because the Minimum Detectable Activities ( MDA ) varied greatly in different studies, some small-scale measurements [ 7–9 ] conducted in China could not be pooled and analyzed.…”

Section: Introductionmentioning

confidence: 99%

Measurements of 131I activity in thyroid of workers at the place of radioiodine therapy in 38 hospitals in China

Li,

Zhang,

Wang

et al. 2024

Journal of Radiation Research

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To investigate the levels of 131I activity in thyroid of workers at the place of radioiodine therapy and their main influential factors in China, 341 workers at 38 hospitals performing radioiodine therapy procedure in five provinces were recruited to be measured in 2021. A hand-held gamma spectrometer with NaI(Tl) probe was plastered to the thyroids and thighs of the subjects during the measurement, and each measurement time was 120 s. The internal exposure dose was calculated, and the committed effective dose was estimated. In 86 (25.22%) of the 341 examined workers, 131I thyroid activity was above minimum detectable activity (MDA, 26.6 Bq). The maximum activity was 4.9 × 103 Bq. The detection results above MDA were at 22 (57.89%) different hospitals. The detectable rate for private hospitals (4.8%) was significantly lower than that for public hospitals (26.6%), P < 0.05. The detectable rate for hospitals in provincial capital cities (15.4%) was significantly lower than in nonprovincial capital cities (41.7%), P < 0.001. The detectable rate for hospitals engaged in 131I therapy for thyroid cancer (31.2%) was significantly higher than only for hyperthyroidism (10.3%), P < 0.001. A total of 32 subjects’ committed effective dose might exceed 1 mSv. Results indicated the 131I activity in the thyroid of workers at the place of radioiodine varied considerably in China, and mainly related to ownership, location and therapy program of the hospitals.

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Necessity of Internal Monitoring for Nuclear Medicine Staff in a Large Specialized Chinese Hospital

Cited by 6 publications

References 11 publications

Biological Effects Associated with Internal and External Contamination of Diagnostic Nuclear Medicine Sources

Biological Effects Associated with Internal and External Contamination of Diagnostic Nuclear Medicine Sources

Avaliação das Exposições Ocupacionais Internas em Medicina Nuclear – Dificuldades e Alternativas

Measurements of 131I activity in thyroid of workers at the place of radioiodine therapy in 38 hospitals in China

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