Neck and Waist Circumference Biomarkers of Cardiovascular Risk in a Cohort of Predominantly African-American College Students: A Preliminary Study

Arnold, Thaddeus J.; Schweitzer, Amy; Hoffman, Heather J.; Onyewu, Chiatogu; Hurtado, Maria Eugenia; Hoffman, Eric P.; Klein, Catherine J.

doi:10.1016/j.jand.2013.07.005

Cited by 32 publications

(45 citation statements)

References 28 publications

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“…AIMM Young is an ongoing project that concentrates on the genetics of metabolic syndrome in young adults (21). It functions as a collaborative between the Georgetown-Howard Universities Center for Clinical and Translational Science and Children's National Medical Center.…”

Section: Methodsmentioning

confidence: 99%

Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage

Barfield¹,

Uaesoontrachoon

et al. 2014

Human Molecular Genetics

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A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated with multiple inflammatory states, severity of Duchenne muscular dystrophy (DMD) and muscle size in healthy young adults. We sought to define the mechanism of action of the polymorphism, using allele-specific in vitro reporter assays in muscle cells, and a genotype-stratified intervention in healthy controls. In vitro reporter constructs showed the G allele to respond to estrogen treatment, whereas the T allele showed no transcriptional response. Young adult volunteers (n = 187) were enrolled into a baseline study, and subjects with specific rs28357094 genotypes enrolled into an eccentric muscle challenge intervention [n = 3 TT; n = 3 GG/GT (dominant inheritance model)]. Female volunteers carrying the G allele showed significantly greater inflammation and increased muscle volume change as determined by magnetic resonance imaging T1- and T2-weighted images after eccentric challenge, as well as greater decrement in biceps muscle force. Our data suggest a model where the G allele enables enhanced activities of upstream enhancer elements due to loss of Sp1 binding at the polymorphic site. This results in significantly greater expression of the pro-inflammatory OPN cytokine during tissue remodeling in response to challenge in G allele carriers, promoting muscle hypertrophy in normal females, but increased damage in DMD patients.

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Section: Methodsmentioning

confidence: 99%

Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage

Barfield¹,

Uaesoontrachoon

et al. 2014

Human Molecular Genetics

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“…Neck circumference might be a better index than waist circumference or other indicators for determining metabolic syndrome or its components, and neck circumference is easily determined and has little variability [8][9][10][11] . According to Hoebel et al 6 and others [12][13][14] , neck circumference can be a useful biomarker of risk factors in metabolic syndrome, such as insulin resistance, central obesity, blood pressure, fasting glucose levels and triglycerides. Stabe et al 12 found that neck circumference was strongly associated with insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Neck circumference might predict gestational diabetes mellitus in Han Chinese women: A nested case–control study

Liu

et al. 2016

J of Diabetes Invest

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Aims/IntroductionA large neck circumference might be an indicator of metabolic syndrome and its components, and for certain patients is more practical as an index than waist circumference. The demarcation value for neck circumference that suggests metabolic syndrome appears to vary by ethnic group. Gestational diabetes mellitus is considered a component of metabolic syndrome in pregnant women. We investigated whether neck circumference in Han Chinese women is associated with gestational diabetes mellitus in early pregnancy, and determined a predictive demarcation value.Materials and MethodsA nested case–control study was carried out with 255 women aged 18–35 years. Gestational diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association through a 2‐h, 75‐g oral glucose tolerance test.ResultsOf the total population, 41 (16%) women developed gestational diabetes mellitus by 24–28 weeks of gestation. Neck circumference at gestational week 16 positively correlated with pre‐pregnancy waist circumference, bodyweight and body mass index, and maternal age (P = 0.029) and hemoglobin A1c at gestational week 24 (P ≤ 0.001). By binary logistic regression, neck circumference was an independent predictor of gestational diabetes mellitus (odds ratio 1.840, 95% confidence interval 1.040–3.254; P = 0.036). According to the receiver operating characteristic curve, for predicting gestational diabetes mellitus the optimal demarcation for neck circumference at gestational week 16 was 35.15 cm.ConclusionsNeck circumference is a viable tool to screen for gestational diabetes mellitus. In this population of pregnant Han Chinese women, a neck circumference of ≥35.15 cm was a predictor of gestational diabetes mellitus.

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“…Neck circumference as an index for upper-body subcutaneous adipose tissue distribution has been associated with cardiometabolic risk across various ethnicities in the general population [2–7]. In the Framingham Heart Study, including 2732 individuals, Preis et al [6,8] found that neck circumference was positively associated with risks of type 2 diabetes, hypertension.…”

Section: Introductionmentioning

confidence: 99%

Neck circumference and prehypertension

Liang

Wang

Liu

et al. 2015

Journal of Hypertension

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Background We have previously found that neck circumference was related to insulin resistance, a risk factor for hypertension in Chinese. Little is known about whether high neck circumference is associated with elevated blood pressure. Method The study samples were from a community-based health examination survey in central China. In total, 1709 men and women with neck circumference measurement were included. We analysed the associations between neck circumference and the risk of prehypertension. Results Although neck circumference was strongly associated with SBP/DBP in a univariate analysis, it was no longer associated with SBP and the association was much weaker with DBP when the association was adjusted for BMI or waist circumference. Similarly, high neck circumference was significantly related to an increased risk of prehypertension [odds ratio 1.254; 95% confidence interval (95% CI) 1.171–1.343] in a univariate analysis, and the association became marginal in models further adjusting for BMI or waist. Conclusion Our data suggest that neck circumference as predictor for prehypertension is not obvious given the moderate improvement of disease prediction.

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Neck and Waist Circumference Biomarkers of Cardiovascular Risk in a Cohort of Predominantly African-American College Students: A Preliminary Study

Cited by 32 publications

References 28 publications

Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage

Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage

Neck circumference might predict gestational diabetes mellitus in Han Chinese women: A nested case–control study

Neck circumference and prehypertension

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