Neck input modifies the reference frame for coding labyrinthine signals in the cerebellar vermis: a cellular analysis

Manzoni, Diego; Pompeiano, O.; Bruschini, Luca; André, Paolo

doi:10.1016/s0306-4522(99)00275-4

Cited by 47 publications

(34 citation statements)

References 53 publications

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“…Once in the fastigial nucleus, however, two distinct populations of vestibular-related neurons have been described: one group that responds to low-frequency (Ͻ1 Hz) sinusoidal vestibular stimulation and another group that is tuned toward frequencies Յ10 Hz (Schlosser et al 2001). The fastigial nucleus contains vestibular-related neurons that respond to vestibular signals with the appropriate coordinate transformation necessary to elaborate motor commands appropriate for whole-body responses (Brooks and Cullen 2009;Kleine et al 2004;Manzoni et al 1999). These behaviors are similar to the vestibularevoked muscle and sway responses that show well-defined spatial transformations related to the position of the head relative to the feet (Britton et al 1993;Fitzpatrick et al 1994;Lund et al 1983;Mian and Day 2009) and distinct low-and higher-frequency response characteristics to vestibular stimuli (as described here).…”

Section: Discussionmentioning

confidence: 94%

Frequency-Specific Modulation of Vestibular-Evoked Sway Responses in Humans

Dakin

Luu

Doel³

et al. 2010

Journal of Neurophysiology

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Dakin CJ, Luu BL, van den Doel K, Inglis JT, Blouin J-S. Frequency-specific modulation of vestibular-evoked sway responses in humans. J Neurophysiol 103: 1048 -1056, 2010. First published December 23, 2009 doi:10.1152/jn.00881.2009. Galvanic vestibular stimulation (GVS) results in characteristic muscle and whole-body responses in humans maintaining standing balance. However, the relationship between these two vestibular-evoked responses remains elusive. This study seeks to determine whether mechanical filtering from conversion of lower-limb muscle activity to body sway, during standing balance, can be used to attenuate sway while maintaining biphasic lower-limb muscle responses using frequency-limited stochastic vestibular stimulation (SVS). We hypothesized that SVS deprived of frequencies Ͻ2 Hz would evoke biphasic muscle responses with minimal whole-body sway due to mechanical filtering of the higher-frequency muscle responses. Subjects were exposed to five stimulus bandwidths: two meant to induce sway responses (0 -1 and 0 -2 Hz) and three to dissociate vestibular-evoked muscle responses from whole-body sway (0 -25, 1-25, and 2-25 Hz). Two main results emerged: 1) SVS-related sway was attenuated when frequencies Ͻ2 Hz were excluded, whereas multiphasic muscle and force responses were retained; and 2) the gain of the estimated transfer functions exhibited successive low-pass filtering of vestibular stimuli during conversion to muscle activity, anteroposterior (AP) moment, and sway. This successive low-pass filtering limited the transfer of signal power to frequencies Ͻ20 Hz in muscle activity, Ͻ5 Hz in AP moment, and Ͻ2 Hz in AP trunk sway. Consequently, the present results show that SVS delivered at frequencies Ͼ2 Hz to standing humans do not cause a destabilizing whole-body sway response but are associated with the typical biphasic lower-limb muscle responses.

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Section: Discussionmentioning

confidence: 94%

Frequency-Specific Modulation of Vestibular-Evoked Sway Responses in Humans

Dakin

Luu

Doel³

et al. 2010

Journal of Neurophysiology

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“…The rostral fastigial nucleus represents the main output of the medial zone of the anterior vermis (Voogd, 1989), the role of which in vestibular-somatosensory interactions has received strong experimental support (Manzoni et al, 1998(Manzoni et al, , 1999. In fact, Manzoni et al (1999) have previously reported that static neck input modulates the responses of anterior vermis Purkinje cells during complex vestibular stimulation in decerebrate cats. The present results show that these vestibular-somatosensory interactions implement a coordinate transformation to estimate motion of the body through space.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive convergence of vestibular and somatosensory signals has been reported in motion-sensitive areas of the brainstem vestibular nuclei (VN), cerebellar cortex (e.g., anterior and posterior cerebellar vermis), and deep cerebellar nuclei (Boyle and Pompeiano, 1981;Anastasopoulos and Mergner, 1982;Wilson et al, 1990;Manzoni et al, 1998Manzoni et al, , 1999McCrea, 1999, 2000;McCrea et al, 1999). At present, it is not known whether this convergence reflects an underlying reference frame transformation to compute body motion in space.…”

Section: Introductionmentioning

confidence: 99%

Multiple Reference Frames for Motion in the Primate Cerebellum

Shaikh¹,

Hui²,

Angelaki³

2004

J. Neurosci.

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Knowledge of body motion through space is necessary for spatial orientation, self-motion perception, and postural control. Yet, sensory afferent signals may not directly provide such information to the brain. Because motion detected by the vestibular end organs is encoded in a head-fixed frame of reference, a coordinate transformation is thus required to encode body motion. In this study, we investigated whether cerebellar motion-sensitive neurons encode the translation of the body through space. We systematically changed both the direction of motion relative to the body and the static orientation of the head relative to the trunk. The activities of motion-sensitive neurons in the most medial of the deep cerebellar nuclei, the rostral fastigial nucleus, were compared with those in the brainstem vestibular nuclei. We found a distributed representation of reference frames for motion in the rostral fastigial nucleus, in contrast to cells in the vestibular nuclei, which primarily encoded motion in a head-fixed reference frame. This differential representation of motionrelated information implies potential differences in the functional roles of these areas.

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“…Recent studies suggest that Purkinje cells in the posterior cerebellar vermis (nodulus and ventral uvula) encode such spatially transformed canal signals (Angelaki et al 2010;Yakusheva et al 2007). Other studies have provided evidence that deep cerebellar neurons in the rostral fastigial nucleus and Purkinje cells in the anterior vermis carry vestibular signals that have been at least partially transformed into a body-centered reference frame (Kleine et al 2004;Manzoni et al 1999;Shaikh et al 2004). Furthermore, a recent study has explicitly shown that, for movements in the horizontal plane, many neurons in the rostral fastigial nuclei combine vestibular and neck proprioceptive signals precisely as required to compute body motion (Brooks and Cullen 2009).…”

Section: Reference Frame Transformation Of Vestibular Signals For Reamentioning

confidence: 99%