Necrobacillosis—A Resurgence?

Liu, Andrea C.Y.; Argent, Julie

doi:10.1053/crad.2001.0806

Cited by 20 publications

(16 citation statements)

References 32 publications

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“…necrophorum has been presumed to be part of the commensal flora of the oral cavity due to its close association with infections of the head and neck region. [24][25][26] However, despite an extensive search of the literature there is no published evidence of this. In a recent study of infected dental root canals however Gomes et al 27 recovered F. necrophorum from 23.3% of samples (nZ 60).…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre's disease

Batty

Wren

Gal

2005

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre's disease

Batty

Wren

Gal

2005

Journal of Infection

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“…With the ensuing decline in the condition, this experience was then virtually forgotten for 30 years, to be rediscovered with the realization that this striking condition still existed and indeed was undergoing a resurgence (52,136,177,245,247,253,312).…”

Section: Historical Reviewmentioning

confidence: 99%

“…In this regard, in a small proportion of cases, infection seems to have become established following some form of trauma to the tonsils or oropharynx. Liu and Argent et al (247) described a case in which a labial frenectomy had been undertaken shortly before onset. In two reports (32,323), infection occurred after tonsillectomy.…”

Section: Host Factorsmentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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“…It was first described in 1936 by A. Lemierre, professor of Bacteriology in the Faculty of Medicine, Paris [2]. Lemierre was mainly concerned with postanginal necrobacillosis, but he did recognize that the septicaemia can occur without a preceeding sore throat [3].…”

Section: Discussionmentioning

confidence: 99%