Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of <scp>ANA</scp> and <scp>ASMA</scp> autoantibodies

Borgia, Francesco; Russo, Giuseppina T.; Villari, Provvidenza; Guarneri, Fabrizio; Cucinotta, Domenico; Cannavò, Serafinella Patrizia

doi:10.1002/ccr3.57

Cited by 5 publications

(8 citation statements)

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“…Increasing evidence suggests that NL may be induced by immunological mechanisms, in which either an immune complex disease or autoantibodies targeting vessel wall tissue antigens represent the triggering events. This hypothesis is supported by the detection of immunoglobulins and complement factor deposits, especially immunoglobulin M (IgM), C3, and fibrin, in vessel walls and the dermal-epidermal junction of the affected skin [6,17]. An immune-mediated process is also suggested by the stronger association with type 1 DM rather than with type 2 DM.…”

Section: Introductionmentioning

confidence: 94%

“…The paucity of epidemiological data on NL in other immune-mediated conditions could partly be explained by the absence of adequate clinical screening for this disease, which has traditionally been considered a specific manifestation of DM. Furthermore, most of the cohort studies documented in the literature have focused on therapeutic rather than epidemiological aspects [6]. In this regard, a recent multicenter retrospective study, examining the data of 52 patients with NL of the lower legs, found a prevalence of thyroid function disorders in 13%, compared to 5.5% in the general population, suggesting that NL could be associated with other conditions than DM alone [7].…”

Section: Introductionmentioning

confidence: 99%

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Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Li Pomi,

Motolese,

Paganelli

et al. 2024

IJMS

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Necrobiosis Lipoidica (NL) is a dermatological condition characterized by the development of granulomatous inflammation leading to the degeneration of collagen and subsequent formation of yellowish-brown telangiectatic plaques usually localized on the pretibial skin of middle-aged females. Due to its rarity and unclear etiopathogenesis, therapeutic options for NL are not well-standardized. Among them, photodynamic therapy (PDT) is an emerging tool, although its efficacy has primarily been evaluated in single case reports or small case series. This study reports the real-life experience of a cohort of NL patients treated with PDT at the Section of Dermatology of the University Hospital of Messina and Reggio-Emilia. From 2013 to 2023, 17 patients were enrolled —5 males (29%) and 12 females (71%) aged between 16 and 56 years (mean age: 42 ± 13 years), with a median duration of NL of 8 years. The overall complete clearance (>75% lesion reduction) was 29%, while the partial clearance (25–75% lesion reduction) was 59%, with 12% being non-responders. This study adds to the little amount of evidence present in the literature regarding the effectiveness of PDT in the treatment of NL. Variability in treatment responses among patients underscores the need for personalized protocols, optimizing photosensitizers, light sources, and dosimetry. The standardization of treatment protocols and consensus guidelines are essential to ensure reproducibility and comparability across studies.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Li Pomi,

Motolese,

Paganelli

et al. 2024

IJMS

Self Cite

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“…Thyroid disorders, such as Graves disease and Hashimoto disease, have been documented in certain patients with NL lesions on the lower extremities [10,29,100]. Erfurt-Berge et al reported in their 2012 study, that from a group of 52 participants, 7 individuals were found to have thyroid disease [63].…”

Section: Thyroid Diseasementioning

confidence: 99%

“…Erfurt-Berge et al reported in their 2012 study, that from a group of 52 participants, 7 individuals were found to have thyroid disease [63]. There is currently no established causal association between the two disorders; nonetheless, there has been speculation regarding the presence of autoantibodies or deposition of autoimmune complexes [29,100]. In both cases, there is growing evidence suggesting that NL may be triggered by an immunological mechanism, in which either an immune complex disease or autoantibodies are directed against vessel wall tissue antigens [100].…”

Section: Thyroid Diseasementioning

confidence: 99%

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Ionescu,

Petca,

Dumitrașcu

et al. 2024

Biomedicines

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Background: Necrobiosis lipoidica (NL) is a rare granulomatous skin disorder with a predilection for females, often associated with diabetes mellitus (DM). This paper aims to comprehensively review the literature on NL, focusing on its association with DM, thyroid disorders, and the metabolic syndrome. Methods: A systematic search was conducted in English-language literature from inception to October 2023, utilizing PubMed. We identified 530 studies and selected 19 based on clinical significance, statistical support, and relevance to the paper’s goals. Results: The coexistence of NL and DM is prevalent, with rates ranging from 11% to 65.71%. NL may precede DM diagnosis and a correlation between NL and increased daily insulin requirements has been observed in such patients. NL is suggested as a potential prognostic marker for DM complications; however, recent studies question this association, highlighting the need for further research. Studies in the context of NL and Thyroid Disease indicate a correlation, especially with autoimmune thyroiditis. Regarding NL and Metabolic Syndrome, the prevalence of metabolic syndrome among NL patients is notably higher than in the general population. Additionally, DM patients with ulcerated NL commonly exhibit hypertension or obesity, raising questions about the potential influence of hypertension and obesity on NL ulcerations. Conclusion: Additional research is required to untangle the complex connections between NL and various comorbidities.

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“…zu Diabetes-Patienten ohne NL [16]. Insbesondere ein assoziiertes Auftreten einer Autoimmunthyreoiditis sollte abgeklärt werden [19]. Eigene Untersuchungen zeigen, dass das Auftreten von Bluthochdruck, Übergewicht und Schilddrüsenfunktionsstörungen mit dem Auftreten von ulzerierten NL-Läsionen einherzugehen scheint [12].…”

Section: Assoziierte Erkrankungenunclassified

Necrobiosis lipoidica – Klinische Charakteristika und therapeutische Ansätze

Erfurt‐Berge

Schliep

2019

Akt Dermatol

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ZusammenfassungDie Necrobiosis lipoidica ist eine seltene granulomatöse Dermatose, die sich vornehmlich an den Streckseiten der unteren Extremitäten mit gelblich-bräunlichen Plaques manifestiert. Ulzerationen können den Verlauf erschweren. Klare Therapieempfehlungen fehlen, da aufgrund der geringen Patientenzahlen keine großen randomisierten Studien vorliegen. Neben dem Einsatz von Glukokortikoiden scheinen Fumarsäureester und Biologika therapeutisch vielversprechend.

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Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies

Cited by 5 publications

References 5 publications

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Necrobiosis lipoidica – Klinische Charakteristika und therapeutische Ansätze

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