Nécrolyse épidermique toxique. Revue des cas observés dans le service de réanimation du centre national hospitalier et universitaire de Cotonou

Aguemon, A. R.; Houngbe, Fabien; Yaméogo, Tènè Marceline; Tchaou, Blaise Adelin; Madougou, Saïdou; Lokossou, T.; Hounkpe, P.

doi:10.1016/j.annfar.2006.01.012

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…A multicentric study comprising several West African francophone countries objectified a similar incidence of 4 cases/ year and per country [1]. Furthermore, compared to the previous studies carried out in our department and in the sub-region, we have noted an increased incidence of TEN [3,4,6]. This high incidence of ACDR and notably that of the Lyell syndrome in our regions compared to the West might partly be explained by self-medication, especially with drugs bought in the street, poly-medication, the circulating counterfeit drugs, phytotherapy, as well as the high rate of HIV prevalence [1].…”

Section: Discussionsupporting

confidence: 78%

“…Like in almost all African series, the antibacterial sulfonamides were mostly in cause in the occurrence of the TEN in our study [2][3][4][5]16]. There are, of course often of allergenic nature, but this is also favored by the frequent and extensive prescribing practice of nurses.…”

Section: Discussionsupporting

confidence: 66%

“…Over the last few years, several studies have been carried out on the Lyell syndrome or Toxic Epidermal Necrolysis (TEN) in sub-Saharan Africa [1][2][3][4][5][6]. It appears that this disease's prevalence is still higher in this region compared to the West [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Toxic Epidermal Necrolysis in Senegal, 2005 Through 2015: Epidemiological and Drug Etiology

Diallo¹,

Diop²,

Diadié³

et al. 2017

Dermatol Case Rep

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Introduction: The aim of this study was to determine the epidemiological and drug etiology of the toxic epidermal necrosis (TEN) or Lyell's syndrome in our Department. Patients and Methodology: Medical records of all admitted patients for TEN over an eleven-year period were analysed retrospectively. Findings: We collected 251 cases of drug-induced skin reactions, representing 0.3% of medical visits and 0.7% of admissions. On average, 5 patients suffering from TEN were hospitalized every year. They mostly consisted of young women with a mean age of 35 ± 19.71 years and a sex-ratio of 0.5. About half of patients have been evacuated by road from the various provinces of the country, sometimes over 500 km away. The culprit drug was prescribed by a nurse of an infirmary in 35% of the cases. A self-medication with a drug bought in the street or in a pharmacy was found in 24 patients (40%). There was poly-medication in 17 patients (28%). The inducing drugs were mostly sulphonamides, neuroleptics, paracetamol, allopurinol and NSAI. An oral phytotherapy (Momordica charantia and Guiera senegalensis) induced the TEN in 2 patients. Death occurred in 18 patients (30%). Discussion: Lyell syndrome is still frequent in sub-Saharan Africa where its prevalence even seems to be increased. Its incidence is probably favorised by self-medication especially with street medicines, unregulated access to drugs, inappropriate prescriptions, the circulation of counterfeit medicines, as well as the high prevalence of HIV. The remoteness of patients from dermatological department and the lack of sanitary evacuation systems explain its still poor prognosis in our regions.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Toxic Epidermal Necrolysis in Senegal, 2005 Through 2015: Epidemiological and Drug Etiology

Diallo¹,

Diop²,

Diadié³

et al. 2017

Dermatol Case Rep

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show abstract

“…In our series, 45.2% (28/62) of patients had consumed at least 2 medications before the onset of the rash. In the series published by Aguèmon on Lyell syndrome in intensive care settings, the majority of patients used several medications (27.42%) [13]. The seroprevalence of HIV in our study was 6.5% (4/62).…”

Section: Discussionsupporting

confidence: 43%

“…In the study of Sa iatou [6]. Paracetamol was responsible for toxicity in 23.08% of patients; penicillin was found in several authors [12][13][14]. This predominance of antiinfectious sulfamides is explained on the one hand by the high consumption of these molecules linked to its use in palustrine syndromes, respiratory and digestive diseases, and on the other hand, because of its availability both in the stores and in the parallel market of our cities.…”

Section: Discussionmentioning

confidence: 99%