Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order

Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis

“…In 2004, Durand et al reported that the in vivo induction of endothelial cell apoptosis leads to both vessel thrombosis and endothelial denudation [ 25 ]. Necroptosis plays pivotal roles in platelet prothrombotic responses and contributes to clot formation [ 26 , 27 ]. Notably, in this study, ferroptosis was the 14th pathway among the top 30 pathways identified via KEGG analysis (Figure B).…”

Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer

“…Subsequently, phosphorylation and transphosphorylation occur on both RIPK1 and RIPK3. Phosphorylated RIPK3 recruits MLKL which then undergoes phosphorylation to form a necrosome structure 245 , 250 . Ultimately, phosphorylated MLKL undergoes oligomerization and translocation to the plasma membrane where it forms pore complexes leading to damage-associated molecular pattern (DAMP) secretion as well as cellular swelling and membrane rupture triggering necroptosis 4 , 244 .…”

Podocyte injury and death: New insights into lupus nephritis pathogenesis and therapy

“…75,78,82 Interferon stabilizes MLKL expression, thereby enabling the oligomerization of MLKL and the execution of necroptosis. 76,86,87 Enhancement of RIP3 levels and the subsequent initiation of necroptotic pathways have been noted in podocytes. These patterns were inversely related to proteinuria, blood urea nitrogen, and renal inflammation parameters.…”

“…Interferon stabilizes MLKL expression, thereby enabling the oligomerization of MLKL and the execution of necroptosis 76,86,87 . Enhancement of RIP3 levels and the subsequent initiation of necroptotic pathways have been noted in podocytes.…”