Necrosis cutánea y peneana inducidas por warfarina

Pinzón, Alfredo; Arias, Catalina; Cárdenas, Ana Marı́a

doi:10.36104/amc.2012.515

Cited by 1 publication

(2 citation statements)

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“…It was found that WSN developed within a time less than or equal to 15 days in 75% of patients receiving a median treatment time of 6.5 days, indicating that a proportion of people develop this complication late. Indeed, some authors described the WSN development after one month to 10 years of warfarin use and in whom treatment was reinitiated 4,21‐25 . Recent publications still consider a period of up to 3 years 26 ; however, we can state that it can be much longer.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Systematic review of warfarin‐induced skin necrosis case reports and secondary analysis of factors associated with mortality

Morán‐Mariños

Corcuera-Ciudad

Velásquez-Rimachi

et al. 2021

Int J Clinical Practice

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Warfarin is one of the most commonly prescribed and used oral anticoagulants worldwide (0.5%-1.5%), it is mainly prescribed to individuals with atrial fibrillation. 1,2 Warfarin-induced skin necrosis (WSN) is a rare and severe adverse reaction, affecting between 0.01% and 0.1% of patients who take warfarin. It has a mortality rate of 15% within three months of the acute event. 3,4 Hypersensitivity to this drug is caused by a reaction to local factors such as trauma, inadequate perfusion, viral infections and hereditary or dysfunctional protein C and S. These factors cause a transient imbalance between procoagulant and anticoagulant systems producing a hypercoagulable state, and consequently, microthrombi that trigger skin necrosis. 5,6 WSN is characterised by rapidly progressive lesions that appear 3-10 days after the initiation of therapy, often affecting areas of major subcutaneous tissue, such as breasts, buttocks and abdomen. 7,8 Few studies have analysed WSN, and no study has identified the factors associated with mortality, probably because of the low incidence of this event. For this reason, we conducted a systematic review of case reports of WSN, including a Peruvian case, exploring the clinical characteristics of patients and the factors associated with mortality because of WSN-related complications.

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Section: Discussionmentioning

confidence: 98%

“…Indeed, some authors described the WSN development after one month to 10 years of warfarin use and in whom treatment was reinitiated. 4,[21][22][23][24][25] Recent publications still consider a period of up to 3 years 26 ; however, we can state that it can be much longer.…”

Section: Summary Of Evidence and Contrast With The Selected Literaturementioning

confidence: 95%