Necrosis of infantile haemangioma with propranolol therapy

Grech, Jamie Alexander; Calleja, Thomas; Soler, P; Pace, David

doi:10.1136/archdischild-2018-316478

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Tissue debridement revealed a large ulcer, which healed in two weeks. Propranolol was restarted without incident after the healing [17]. The patient also showed a rapid aggravation of the ulceration, which became wide and deep two weeks after the initiation of propranolol.…”

Section: Discussionmentioning

confidence: 99%

Adverse effects of propranolol in a fulminant ulcerated infantile hemangioma

Oulehri¹,

Baybay²,

Elloudi³

et al. 2022

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Infantile hemangiomas (IHs) are the most common tumors of infancy, with a global prevalence estimated at 1% to 10% of infants. Most hemangiomas are small and regress spontaneously without a need for intervention. However, 5% to 10 % of hemangiomas may cause serious complications and require treatment. Herein, we report the case of a two-month-old female infant with a left hemifacial hemangioma, which became severely ulcerated after the introduction of propranolol. We also report a good improvement afterwards due to combined therapy. An ulcerated infantile hemangioma is the most common complication seen in an IH, which may present a therapeutic challenge especially in the case of concurrent hemorrhage or infection. Although numerous studies support its efficacy and reduced side effects. propranolol may worsen the ulceration of an IH, possibly reflecting a reduced blood flow, causing peripheral ischemia. In some cases of IH with complex ulceration, monotherapy with propranolol may be insufficient.

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Section: Discussionmentioning

confidence: 99%