Necrotising stomatitis as a presenting symptom of HIV

Agbelusi, GA; Eweka, O.M.

doi:10.4236/ojst.2011.14025

Cited by 5 publications

(15 citation statements)

References 7 publications

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“…This is in line with the findings of other authors like Buchanan et al [3] and Agbelusi et al [1]. A biopsy of NS was not needed because its usually not indicated since the histology is not pathognomonic [7].…”

Section: Discussionsupporting

confidence: 88%

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Necrotizing Stomatitis in a Non-HIV Patient: A Case Presentation

Abah¹,

Agbelusi²

2013

Journal of Case Reports in Medicine

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Necrotizing stomatitis (NS) is an uncommon oral ulceration associated with reduced immunity, recent illness, and unusual life stress. It can be seen in malnourished children and HIV-infected adults, but it is very uncommon in non-HIV adults. Objective. To present a case of NS in a non-HIV adult. Methodology. We present a previously misdiagnosed case of NS in a non-HIV 27-year-old female whose immunity was compromised by several factors including malnutrition, chronic anemia, drug treatment of rheumatoid arthritis, and fibrous TMJ ankylosis. Several factors mitigating the diagnosis and successful treatment of this patient are discussed. Conclusion. This presentation highlights a challenging case of NS complicated by several unusual factors. It serves to educate the dental practitioners on the interplay of factors which if not addressed will mitigate successful management of the patient.

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Section: Discussionsupporting

confidence: 88%

“…NS has been reported in HIV seropositive as demonstrated by Feller et al [6] and Agbelusi et al [1]. In our own case, the patient was HIV negative with underlying medical conditions which would have lowered her immunity, predisposing her to NS.…”

Section: Discussionsupporting

confidence: 55%

Necrotizing Stomatitis in a Non-HIV Patient: A Case Presentation

Abah¹,

Agbelusi²

2013

Journal of Case Reports in Medicine

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“…Necrotizing Ulcerative Stomatitis (NUS) merupakan penyakit inflamasi pada rongga mulut yang ditandai destruksi epitel, jaringan ikat dan papila. 1,2 NUS pertama kali dilaporkan pada tahun 1990 oleh Williams sebagai infeksi ulseratif nekrotik pada gingiva yang meluas ke jaringan mukosa dan palatal serta mengakibatkan kerusakan tulang. 3 NUS dapat menyebabkan hilangnya perlekatan periodontal dan destruksi tulang, pada tahap lanjut dapat menyebabkan cancrum oris (NOMA).…”

Section: Pendahuluanunclassified

Necrotizing ulcerative stomatitis mimicking erythema multiforme pada pasien dengan HIV seronegatif

Munthe

Setiadhi

2020

J Ked Gi Unpad

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ABSTRAKPendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan inflamasi akut yang ditandai destruksi, ulserasi serta nekrosis epitel, jaringan ikat dan papila. Umumnya terjadi pada pasien malnutrisi dan Human Immunodeficiency Virus (HIV) seropositif. Lesi awal berupa necrotizing gingivitis kemudian berkembang menjadi necrotizing periodontitis, selanjutnya menjadi NUS. Gambaran klinis kasus NUS kadang serupa dengan Erythema multiforme (EM), sehingga perlu dilakukan pemeriksaan penunjang yang dapat menegakkan diagnosa dengan tepat. Tujuan laporan kasus ini melaporkan cara menegakkan diagnosis NUS yang menyerupai EM secara tepat pada pasien dengan suspek infeksi HIV. Laporan kasus: Pasien laki-laki berusia 49 tahun dirujuk ke departemen Ilmu Penyakit Mulut dengan diagnosis EM disertai suspek terinfeksi HIV. Keluhan utama berupa rasa nyeri disertai sariawan pada lidah dan bibir bagian dalam. Pemeriksaan ekstraoral tidak ada kelainan, pada intraoral ditemukan ulser multipel dilapisi sloughing kekuningan pada mukosa labial, mukosa bukal, dorsal lidah, lateral lidah dan ventral lidah. Gingiva anterior rahang bawah terdapat lesi ulseratif disertai jaringan nekrosis. Pemeriksaan darah menunjukkan penurunan hematokrit, peningkatan leukosit, serta negatif pada pemeriksaan tes HIV. Actinomyces naeslundii ditemukan pada pemeriksaan mikrobiologi. Ditegakkan diagnosis NUS dan terapi yang diberikan amoxicillin 500mg, metronidazol 500mg, chlorhexidine gluconate 0,2% dan asam folat. Lesi oral mengalami perbaikan dalam 2 minggu. Simpulan: Lesi oral mengalami perbaikan secara signifikan setelah kontrol ketiga atau seminggu dari kunjungan pertama, pasien sudah dapat makan tanpa rasa nyeri. Gambaran klinis lesi mukosa oral yang khas, serta pemeriksaan penunjang mikrobiologi berperan dalam menunjang diagnosis NUS. Tes HIV perlu dilakukan untuk mengkonfirmasi status infeksi HIV pada pasien. Dokter gigi sebaiknya mengenali tanda dan gejala NUS, sehingga dapat menegakkan diagnosis dan memberikan terapi adekuat serta mencegah meluasnya kerusakan jaringan.

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“…The relationship of LGE to severe immune suppression is variable. This condition may (Ceballos et al, 1996; Holmes et al, 2002) or may not be associated with CD4 counts < 200 cells/mm 3 (Grbic et al, 1995;Davoodi et al, 2010).…”

Section: Studies Have Revealed a Microbiota Comprising Candida Albicamentioning

confidence: 99%

“…Predisposing factors to expression of oral lesions of AIDS include CD4 counts less than 200 cells/mm 3 , viral load greater than 3000 copies/ml, xerostomia, poor oral hygiene and smoking (Greenspan et al, 2001).…”

mentioning

confidence: 99%

Oral Manifestations of HIV

Agbelusi¹,

Eweka²,

Umeizudike³

et al. 2013

Current Perspectives in HIV Infection

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phocyte count falls below 200 cells per ml and the ratio of helper and suppressor cells is reversed, a diagnosis of AIDS is made. 3. Oral manifestations of HIV 3.1. Significance of oral lesions of HIV Oral lesions have been reported to be early clinical features of HIV infection (Greenspan et al., 1992). They are multiple and varied, and are occasionally the first sign that patients harbour the virus. Studies have estimated that more than 90% of persons with HIV infection will have at least one oral manifestation during the course of their disease (Weinert et al., 1996). These lesions may be present in up to 50% of people with HIV infection and in up to 80% of those with a diagnosis of AIDS (Palmer et al., 1996). In cases where a person's HIV status is unknown the lesions provide a strong indication of the presence of HIV infection (Maeve et al., 2005).

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Necrotising stomatitis as a presenting symptom of HIV

Cited by 5 publications

References 7 publications

Necrotizing Stomatitis in a Non-HIV Patient: A Case Presentation

Necrotizing Stomatitis in a Non-HIV Patient: A Case Presentation

Necrotizing ulcerative stomatitis mimicking erythema multiforme pada pasien dengan HIV seronegatif

Oral Manifestations of HIV

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