Necrotizing Angiitis: II. Findings at Autopsy in Twenty-Seven Cases

Reidbord, Howard E.; McCormack, Lawrence J.; O’Duffy, J. Desmond

doi:10.3949/ccjm.32.4.191

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…Interestingly, pathological evidence of gastrointestinal tract involvement in Wegener's granulomatosis has been previously reported, although the course of the disease was usually dominated by the characteristic necrotizing granulomatous lesions in the upper and lower respiratory tracts, along with vasculitis and glomerulonephritis. To date, fewer than 100 cases have been described with gastrointestinal involvement, usually with the characteristic vasculitic pathological features of Wegener's granulomatosis, the so-called palisading granuloma centred on small arteries and veins with fibrinoid necrosis (17)(18)(19)(20)(21)(22)(23)(24). Wegener's granulomatosis may also mimic the changes in IBD and is often considered in the differential diagnosis of patients with colitis (25).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease with Cytoplasmic‐Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis

Freeman

1998

Canadian Journal of Gastroenterology and Hepatology

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A cohort of 18 patients with inflammatory bowel disease who were characterized by the presence of cytoplasmic-staining antineutrophil cytoplasmic antibody (cANCA) and extensive colitis is reported. Almost half were Indo-Canadians, and atypical perinuclear-staining antineutrophil cytoplasmic antibody was also detected in five (28%), similar to the detection rate for Crohn's disease and other less commonly detected forms of colitis, such as lymphocytic or collagenous colitis. Careful pathological review of all endoscopic biopsies and surgically resected colonic tissues did not reveal evidence of vasculitis or so-called 'palisading' granulomas, which is a typical pathological change of Wegener's granulomatosis, an entity that has been traditionally characterized by the detection of cANCA. This report describes 18 patients with extensive colitis and the seromarker cANCA but without clinical features or histological evidence of vasculitis.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease with Cytoplasmic‐Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis

Freeman

1998

Canadian Journal of Gastroenterology and Hepatology

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“…Autopsy studies show biliary involvement in 10-25% of patients [165,166]. Biliary lesions likely result from vasculitis as arterial occlusion by intimal fibrinoid necrosis, thrombosis and granulation tissue have been found around damaged bile ducts [167].…”

Section: Polyarteritis Nodosamentioning

confidence: 99%

Ischemic cholangiopathy

Deltenre

Valla

2006

Journal of Hepatology

123

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“…60 Panarteritis nodosa is characterized by mediumand small-sized arteritis, which can involve almost any organ, including the liver. 64,65 Autopsy studies showed biliary involvement in 10 to 25% of patients, 66,67 and arterial occlusion by intimal fibrinoid necrosis, thrombosis, and granulation tissue have been found around damaged bile ducts. 68 In patients with atherosclerosis, atheromatous stenosis of the arterial branch has been suspected to be Hereditary hemorrhagic telangiectasia 57,58,110 Kawasaki disease 74 Radiotherapy on liver area 60,61 Schö nlein-Henoch purpura 75 Polyarteritis nodosa [66][67][68] Systemic lupus [76][77][78][79] Atherosclerosis and cholesterol-crystal embolism [69][70][71] Antiphospholipid syndrome 80 Paroxysmal nocturnal hemoglobinuria 81 Hypereosinophilic syndrome 82 Cholangiopathy occurring after septic shock 25,83 responsible for corresponding biliary strictures.…”

Section: Etiologymentioning

confidence: 99%

Ischemic Cholangiopathy

Deltenre¹,

Valla²

2008

Semin Liver Dis

109

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Bile ducts are supplied with blood exclusively via hepatic arteries. Obstruction of large arteries is rapidly compensated for by the opening of preexisting intrahepatic or transcapsular collateral arteries, which prevents ischemic damage. Ischemic bile duct injury may occur when small hepatic arteries or the peribiliary vascular plexus are injured, or when all possible arterial blood supplies are interrupted, as is the case in transplanted liver with hepatic artery thrombosis. Most causes of bile duct ischemia are iatrogenic. Systemic diseases involving small hepatic arteries may also be implicated. Depending on the extent and velocity of the arterial obstructive process, ischemic cholangiopathy may present as acute formation of biliary casts, bile duct necrosis, or chronic disease resembling primary sclerosing cholangitis. In many patients, correction of arterial obstruction is not possible. When biliary drainage or reconstruction is not possible or has failed, liver transplantation is the only means of providing potential cure.

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Necrotizing Angiitis: II. Findings at Autopsy in Twenty-Seven Cases

Cited by 14 publications

References 9 publications

Inflammatory Bowel Disease with Cytoplasmic‐Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis

Inflammatory Bowel Disease with Cytoplasmic‐Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis

Ischemic cholangiopathy

Ischemic Cholangiopathy

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