Necrotizing autoimmune myopathy

Babu, Sachin Suresh; Khanna, Laxmi; Saran, Ravindra Kumar; Mittal, Gaurav; Peter, Sudhir; Sebastian, Ivy

doi:10.4103/0972-2327.176864

Cited by 2 publications

(3 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

“…NAM is idiopathic in almost half of the cases whereas other half is usually associated with statin use, malignancy, human immunodeficiency virus (HIV) infection, or connective tissue disease. 2 Several risk factors have been identified. Statin use has so far been the largest identifiable risk factor for NAM, with atorvastatin and simvastatin being the most common ones.…”

Section: Discussionmentioning

confidence: 99%

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Necrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies

Khan

Khalid

Ullah

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

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Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group. It usually presents with severe proximal weakness, lower extremity weakness, and severe fatigue while very rarely does it present with dysphagia and respiratory muscle weakness. Statin use, cancer, and connective tissue disorder are the usual associated risk factors. Anti-signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzyme A reductase are the 2 most common autoantibodies associated with necrotizing autoimmune myopathy. In this article, we present a very rare case of a 66-year-old male who presented with shortness of breath and dysphagia requiring intubation and ventilator support. Creatine kinase was 23 000, myoglobin was 7000, and ANA was positive. All other autoimmune and infectious workup including Lyme disease was unremarkable. Muscle biopsy turned out remarkable for necrotizing myopathy. No evidence of statin use, active malignancy, or connective tissue disease was found. He was treated with high-dose corticosteroids and a short course of intravenous immunoglobulin with very mild improvement in symptoms. Anti-signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzyme A reductase could not be performed as the patient refused to pursue further medical testing. This is a very rare case of idiopathic inflammatory myopathy presenting with bulbar and respiratory muscle weakness requiring ventilator support.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Necrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies

Khan

Khalid

Ullah

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

show abstract

“…Literature about NAM in Indian patients is mostly as case reports. [ 3 4 ] In this article, we have attempted to describe the clinicopathologic features of 15 patients of NAM where the diagnosis was essentially based on muscle biopsy analysis.…”

Section: Introductionmentioning

confidence: 99%