Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn

Abstract

IVIg in the newborn period should be cautiously employed and always administered under strict medical control.

Necrotizing Enterocolitis in a Term Neonate Following Intravenous Immunoglobulin Therapy

“…Although hundreds of babies are successfully treated every year for hyperbilirubinemia with IVIgG, studies are few and with small number of patients [2]. Since IVIgG has been used for decades for neonatal alloimmune thrombocytopenia (NAIT) and sepsis in newborns it has been presumed that it is relatively safe in treatment of hyperbilirubinemia [1].There have been sporadic reports of NEC following IVIgG infusions for NAIT [5] and hemolytic jaundice [6]. Many risk factors have been described in the adult population for thromboembolic events following IVIgG and caution has been advised in those patients at risk [7].…”

Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury

“…Necrotizing enterocolitis (NEC) is one of the leading causes of death among preterm newborn infants cared for in neonatal intensive care units, affecting 5 -8 % of those with a birth weight below 1500 g [4] . Under special conditions, such as congenital heart disease, exposure to antiretroviral drugs [28] or intravenous immunoglobulins [7,19] , NEC may exceptionally strike term newborns but does not occur in older infants and children.…”

Ätiologie, Pathogenese und Therapie des Ikterus bei Neugeborenen

“…Als gravierende Nebenwirkung einer Immunglobulingabe wurden mehrere Fäl-le von nekrotisierender Enterokolitis bei reifen oder fast reifen Neugeborenen beschrieben [23].…”