Necrotizing fasciitis

Sehgal, Virendra; Sehgal, Neeta; Sehgal, Ruchi; Khandpur, Sujay; Sharma, Sonal

doi:10.1080/09546630600696385

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…5). 123 Two cases of polymicrobial NF in adolescents with T1D and poor glycaemic control have been reported. 124 The perineal region was involved in both cases.…”

Section: Necrotizing Fasciitismentioning

confidence: 99%

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Sehgal¹,

Bhattacharya²,

Verma³

2010

Acad Dermatol Venereol

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Juvenile insulin-dependent diabetes mellitus type 1 (IDDM) is a well-recognized worldwide entity, the significance of which has increased because of its recent upsurging trends, warranting attention on variety of its clinical expressions, in particular, pertaining to skin, an aspect seldom taken cognizance of. Hence an endeavour to recap the related dermatoses, such as limited joint mobility syndrome including sclerodermoid (scleroderma-like) changes, xerosis, necrobiosis lipoidica diabeticorum, granuloma annulare, diabetic foot syndrome, has been made. Complexities relating to the recently explored issues of atopic dermatitis and drug hypersensitivity syndrome have also been covered adequately. In addition, the current concepts of the physiopathology of type 1 diabetes-related dermatoses are briefly recapitulated for clarity.

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“…5). 123 Two cases of polymicrobial NF in adolescents with T1D and poor glycaemic control have been reported. 124 The perineal region was involved in both cases.…”

Section: Necrotizing Fasciitismentioning

confidence: 99%

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Sehgal¹,

Bhattacharya²,

Verma³

2010

Acad Dermatol Venereol

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“…The risk factors of necrotizing fasciitis are diabetes mellitus, malnutrion, trauma, operative interventions, and nonsteroidal anti-inflammatory drugs (NSAİDs) usage. [4] Rarely, necrotizing fasciitis can develop due to all-trans-retinoic acid, bisphosphonates, and radiotherapy. [567] In addition, necrotizing fasciitis has also been reported in renal transplant recipient who treated with FK506.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing fasciitis secondary to bevacizumab treatment for metastatic rectal adenocarcinoma

et al. 2014

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Bevacizumab is a recombinant humanized monoclonal antibody that selectively blocks the activity of vascular endothelial growth factor (VEGF) receptor and it is used in metastatic colorectal patients. We present here a case of fatal necrotizing fasciitis in a patient during bevacizumab treatment for colorectal cancer. In our review of the literature, necrotizing fasciitis was not reported before or during bevacizumab treatment.

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“…[5][6][7][8] It is characterized by rapidly spreading inflammation and necrosis of skin, subcutaneous fat, and fascia and is more common in diabetics and immunosuppressed individuals. 8,9 Although it can affect any age group, adults are known to be more commonly affected than children.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary management of periocular necrotising fasciitis: a series of 11 patients

Tambe

Tripathi

Burns

et al. 2011

Eye

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Background Necrotising fasciitis is an uncommon but life-threatening soft tissue infection characterised by rapidly spreading inflammation and necrosis of skin, subcutaneous fat and fascia. Left untreated, the mortality can be more than 70%. Early surgical intervention can reduce morbidity and mortality. Patients and methods This is a series of 11 patients who presented to our oculoplastic and orbit unit with periocular necrotising fasciitis over a period of five years. We present the modes of presentation, predisposing factors, diagnosis, and the multidisciplinary team management of these patients. Results Of the 11 patients, 1 patient died and 2 patients required intensive care management. Of the 10 surviving patients, 8 patients needed further surgical interventions for correction of complications, like eyelid malposition, ptosis and protective or corrective surgery in the form of ectropion correction, skin grafting and other rehabilitative procedures. Conclusion To the best of our knowledge, this is the largest series of periocular necrotising fasciitis in the literature. Necrotising fasciitis is a potentially fatal condition, resulting in a high rate of mortality and morbidity. Early surgical intervention reduces the mortality. A high index of suspicion is needed to make a prompt diagnosis. These patients need expeditious intervention and may require a long follow-up and subsequent surgery for complications related to scarring and other sequelae.

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Necrotizing fasciitis

Cited by 6 publications

References 10 publications

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Necrotizing fasciitis secondary to bevacizumab treatment for metastatic rectal adenocarcinoma

Multidisciplinary management of periocular necrotising fasciitis: a series of 11 patients

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