Necrotizing infundibular crystalline folliculitis: A clinicopathological study

Denisjuk, Natalja; Hilty, N; Pfaltz, Madeleine; Kempf, Werner

doi:10.1016/j.jaad.2011.05.050

Cited by 17 publications

(35 citation statements)

References 9 publications

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“…Lucke et al 1 initially reported it in 2 elderly men, describing it as transepidermal elimination of urate-like crystals. Another case, in a young woman with a history of acne vulgaris, was reported by Kossard et al 2 Recently a series of 12 cases was published by Denisjuk et al 3 NICF is clinically characterized by multiple, well-demarcated papules containing a central plug with a waxy appearance and a variably erythematous border. The lesions show a predilection for the face (especially the forehead), followed by the back and neck.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions show a predilection for the face (especially the forehead), followed by the back and neck. 3 Histologic findings show an epidermal depression filled with a plug containing birefringent filamentous material with a crystalline appearance enclosed by tiers of parakeratosis. The folliculocentric nature of the lesions may not be immediately apparent, sometimes requiring multiple serial sections.…”

Section: Discussionmentioning

confidence: 99%

“…2 Necrosis of the follicular epithelium is frequently found, and not uncommonly bacteria and yeasts are also seen in association with the follicular epithelium. 3 The exact pathogenesis and the nature of the crystalline material are currently unknown. Lucke et al 1 hypothesized that it was composed of urate-like crystals.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that species of bacteria or yeasts, like Propionibacterium and Malassezia, respectively, may play a role in the crystallization of sebum and in the disruption of tonofilaments resulting in the typical filamentous crystalline material. 3 The differential diagnosis for these clinicopathological findings includes mainly the perforating dermatoses, namely, reactive perforating collagenosis and perforating folliculitis, in which a cupshaped depression filled with a plug can be architecturally similar to what is seen in NICF. However, the appearance of the material in the latter entities is clearly different, representing transepidermal elimination of degenerated connective tissue, namely collagen fibers.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Follicular Papules on the Back of an Elderly Man

Cardoso¹,

Leonard

Carton

et al. 2013

JAMA Dermatol

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A man in his 80s presented with multiple papular lesions, located on the upper back, that were asymptomatic and had been present for approximately 4 to 6 months. The lesions had started after a period in hospital for an orthopedic procedure. There was no other significant medical history, namely, hyperuricemia or any evidence of episodes of gout. Physical examination disclosed multiple follicular relatively monomorphic papules 4 to 6 mm in size each, distributed bilaterally over the upper back and shoulders. Each individual lesion consisted of an erythematous papule containing a central yellowish plug with a waxy appearance (Figure, A). There were no other cutaneous or mucosal lesions and the remaining of his physical examination was normal. A biopsy specimen was taken from 1 of the lesions and stained with hematoxylin-eosin (Figure, B and C).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple Follicular Papules on the Back of an Elderly Man

Cardoso¹,

Leonard

Carton

et al. 2013

JAMA Dermatol

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“…Patients present with waxy papules across the forehead or back. [1][2][3][4] We report the first case of NICF from North America. The plug is flanked by columns of parakeratin and seems to be of follicular origin in most instances.…”

Section: Introductionmentioning

confidence: 99%

Necrotizing Infundibular Crystalline Folliculitis Manifesting as a Perforating Mucinosis

Fraga

Gadzia²,

Abraham³

et al. 2013

The American Journal of Dermatopathology

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: Necrotizing infundibular crystalline folliculitis (NICF) is a rare entity manifesting as waxy folliculocentric papules comprised of filamentous birefringent crystalline deposits. We report a case of NICF in an 85-year-old man, presenting as gritty, cream-colored, and erythematous papules across the midline back. Biopsy demonstrated a pale plug comprised of copious mucin. The diagnostic crystals were initially overlooked because of softening of the paraffin block with 10% ammonia solution, which dissolved the crystals in the initial sections. X-ray microanalysis confirmed the organic nature of the crystals. This is the first report of NICF from North America. Our case highlights the presence of mucin in some cases of NICF and serves as a cautionary tale on the pitfalls of postprocessing artifacts in the histology laboratory.

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Inherited Disorders of Cornification

Oji

Metze

Traupe

2016

Rook's Textbook of Dermatology, Ninth Edition

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The majority of keratinization disorders are referred to as Mendelian disorders of cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible scaling or both. This chapter deals with the ichthyoses, palmoplantar keratodermas (PPKs) and miscellaneous cornification disorders such as porokeratoses. It is aimed primarily at dermatologists and physician scientists who have to make a clinical diagnosis and provide adequate management for their patients. Therefore a nosology and classification scheme has been chosen that is based on clinicogenetic and morphological features. Clinical diagnoses are then discussed with their molecular pathology. Part of the chapter addresses the management of congenital ichthyoses. Various tables provide an overview on clinical and/or pathophysiologically related groups of diseases. Finally, several cornification disorders are discussed that do not have a genetic basis, but are acquired or are of unknown aetiology (e.g. acquired ichthyoses/PPKs or perforating keratotic disorders).

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Necrotizing infundibular crystalline folliculitis: A clinicopathological study

Cited by 17 publications

References 9 publications

Multiple Follicular Papules on the Back of an Elderly Man

Multiple Follicular Papules on the Back of an Elderly Man

Necrotizing Infundibular Crystalline Folliculitis Manifesting as a Perforating Mucinosis

Inherited Disorders of Cornification

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