Necrotizing meningoencephalitis in a large mixed-breed dog

Estey, Chelsie M.; Scott, Steven J.; Cerdá-González, Sofía

doi:10.2460/javma.245.11.1274

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…In literature, NLE is mainly affecting Yorkshire terriers, Maltese terriers and a French bulldog (Schatzberg 2005, Higginbotham and others 2007, Timmann and others 2007, Spitzbarth and others 2010), which are all considered small/medium breed dogs in this study. NME has only been once previously described in a large breed dog; a 26 kg Staffordshire bull terrier mix (Estey and others 2014). …”

Section: Discussionmentioning

confidence: 99%

Clinical presentation, diagnostic findings and long‐term survival in large breed dogs with meningoencephalitis of unknown aetiology

2016

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This is the peer-reviewed, manuscript version of the following article:Cornelis, I., Volk, H. A. and De Decker, S. (2016) clinical presentation, diagnostic findings and long-term survival in large breed dogs. 5The aim of this study was therefore to compare the clinical presentation, diagnostic 6 findings and long-term survival between large and small/medium breed dogs diagnosed 7 with MUA. One hundred and eleven dogs met the inclusion criteria. Twenty-eight 8 (25%) dogs were considered large breed dogs, compared to 83 (75%) small/medium 9 breed dogs. Large breed dogs presented significantly more often with a decreased 10 mentation. Age, gender, duration of clinical signs prior to diagnosis, presence of 11 seizures or cluster seizures, variables on complete blood count and cerebrospinal fluid 12 analysis, and all variables on MRI were not significantly different between 13 small/medium and large breed dogs. Median survival time was 281 and 106 days for 14 the large and small/medium breed dogs respectively, with no significant difference in 15 survival curves for both groups. Although considered not typically affected by MUA, 16

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Section: Discussionmentioning

confidence: 99%

Clinical presentation, diagnostic findings and long‐term survival in large breed dogs with meningoencephalitis of unknown aetiology

2016

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“…NME has only been reported in a handful of breeds, including Pug dogs, Papillon, Shih Tzu, Coton de Tulear, Brussels Griffon, Yorkshire Terrier, Maltese, Chihuahua, Pekingese, 7 and recently in 1 larger breed, a Staffordshire Terrier mix. 8 NLE has been previously known as "Yorkie encephalitis," but has been described in other breeds including the French Bulldog. 9 GME has been reported in many different breeds, and should be considered as a differential in any patient that presents for CNS disease, regardless of age and breed.…”

Section: Demographics Of Diseasementioning

confidence: 99%

Immune-Mediated Central Nervous System Disease—Current Knowledge and Recommendations

Vitale

Foss

2019

Topics in Companion Animal Medicine

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“…Prognostic indicators such as age, weight, breed, presence of seizures, CSF abnormalities, and location of lesion burden have previously been investigated with mixed results . Middle aged, small breed dogs are most commonly diagnosed with MUE, however any age, sex, breed, and size of dog can be affected . Formulation of a prognosis for an individual patient is currently based on clinician experience and patient response to therapy in the early phase of treatment.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Study Evaluating Associations Between Midline Brain Shift on Magnetic Resonance Imaging and Survival in Dogs Diagnosed With Meningoencephalitis of Unknown Etiology

Oliphant

Heller

White

2016

Vet Radiology Ultrasound

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Difficulty has been encountered when trying to identify ante mortem prognostic indicators for dogs with meningoencephalitis of unknown etiology (MUE). Identifying MRI imaging parameters associated with prognosis may impact treatment decision-making for clinician and owner. Our hypotheses for this retrospective cohort study are that dogs diagnosed with MUE that had midline shift on brain MRI would have a poorer survival compared to dogs without midline shift; and that younger age, lower weight, and low cerebrospinal fluid (CSF) cell count would be correlated with improved survival. Medical records were reviewed from two institutions. Inclusion criteria included: clinical signs referable to intracranial disease, brain MRI at presentation, abnormal CSF analysis, and negative infectious disease testing. Magnetic resonance imaging scans were evaluated for midline shift using the T2-weighted transverse image at the interthalamic adhesion and at the site of maximal deviation. Fifty-two dogs met the inclusion criteria. Median midline deviation was 0.12 cm. Median survival for dogs with no shift was 906 days and with shift was 84 days. Survival was not significantly different between groups (P = 0.11). This remained true when correcting for age (P = 0.22) and CSF TNCC (total nucleated cell count) (P = 0.12). Age at the time of diagnosis (P = 0.02) and CSF TNCC (P = 0.03) were significantly associated with survival. Cerebrospinal fluid protein value (P = 0.84) and weight (P = 0.82) were not significantly associated with survival. In this study of 52 dogs with MUE, MRI evidence of midline brain shift between 0.04 and 0.3 cm at the level of the interthalamic adhesion was not associated with shorter survival.

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Necrotizing meningoencephalitis in a large mixed-breed dog

Abstract: To the author's knowledge, this is the first report of necrotizing meningoencephalitis in a large mixed-breed dog. Necrotizing meningoencephalitis should be considered as a differential diagnosis in dogs other than small or toy breeds that have signs suggestive of inflammatory disease.

Cited by 5 publications

References 17 publications

Clinical presentation, diagnostic findings and long‐term survival in large breed dogs with meningoencephalitis of unknown aetiology

Clinical presentation, diagnostic findings and long‐term survival in large breed dogs with meningoencephalitis of unknown aetiology

Immune-Mediated Central Nervous System Disease—Current Knowledge and Recommendations

Retrospective Study Evaluating Associations Between Midline Brain Shift on Magnetic Resonance Imaging and Survival in Dogs Diagnosed With Meningoencephalitis of Unknown Etiology

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