Necrotizing periodontal diseases in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: A review

Balaji, Thodur Madapusi; Varadarajan, Saranya; Sujatha, G.; Muruganandhan, Jayanandan; Shanmugapriya, R.; Raj, A. Thirumal; Patil, Shankargouda; Fageeh, Hammam Ibrahim; Fageeh, Hytham N.; Malik, Nida H.; Awan, Kamran Habib

doi:10.1016/j.disamonth.2021.101168

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Antiviral therapy is useful in the lytic stage of the viruses and there are huge sources of latent viruses in periodontal infection [88,89]. So, in many resistant, unremitting periodontitis, antiviral therapies along with mechanical debridement have become the rational treatment.…”

Section: E) Antiviral Agentsmentioning

confidence: 99%

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Mukherjee

2023

OJDOH

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Periodontal disease is a serious global health issue amongst people of all age groups. Non-surgical and surgical treatments, emerging and investigational therapies, lifestyle and systemic health management are amongst the available treatment strategies of periodontal diseases and disorders. However, certain lacunae are associated with these conventional treatment modalities. Conventional formulations available for managing periodontal diseases are tablets, hydrogels, films, wafers, fibre strips, dental devices, etc. These formulations are composed of antibacterial and antiinflammatory drugs. Chronic use of these formulations may lead to several adverse drug reactions. To overcome these drawbacks, advanced research is necessary for the development of non-invasive, cost effective, biocompatible, advanced technologies and regimen such as gene therapy, tissue engineering, nanotechnology, proteomics, vaccines, development of some novel dental formulations and some regimens for the mitigation and cure of several periodontal diseases. In this review, we elaborately discuss the clinical aspects of periodontitis and its available treatment modalities and management strategies with novel approaches for the development of modern therapeutic policies. They would lead to the opening of new avenues in the field of periodontology and provide better patient compliance.

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Section: E) Antiviral Agentsmentioning

confidence: 99%

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Mukherjee

2023

OJDOH

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“…Acyclovir was reported to resolve lesions with no recession in the early stages of herpetic infection [ 94 ]. Antiviral therapy has shown substantial improvement in oral lesions in HIV seropositive individuals [ 95 ]. Chemotherapeutics can be used against viruses in the lytic stage but not in the latent stage.…”

Section: Antiviral Agentsmentioning

confidence: 99%

“…Periodontal tissues may be a possible source of latent viruses [ 94 , 95 , 96 ]. Viral screening should be considered in cases of unremitting periodontitis [ 96 ].…”

Section: Antiviral Agentsmentioning

confidence: 99%

Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review

Yadalam

Varatharajan

Fageeh

et al. 2022

JPM

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Periodontal disease is an infection-driven inflammatory disease characterized by the destruction of tooth-supporting tissues. The establishment of chronic inflammation will result in progressive destruction of bone and soft tissue changes. Severe periodontitis can lead to tooth loss. The disease has complex pathogenesis with an interplay between genetic, environmental, and host factors and pathogens. Effective management consists of plaque control and non-surgical interventions, along with adjuvant strategies to control inflammation and disrupt the pathogenic subgingival biofilms. Recent studies have examined novel approaches for managing periodontal diseases such as modulating microbial signaling mechanisms, tissue engineering, and molecular targeting of host inflammatory substances. Mounting evidence suggests the need to integrate omics-based approaches with traditional therapy to address the disease. This article discusses the various evolving and future drug targets, including proteomics, gene therapeutics, vaccines, and nanotechnology in personalized periodontal medicine for the effective management of periodontal diseases.

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Necrotizing periodontal diseases in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: A review

Cited by 2 publications

References 21 publications

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review

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