Necrotizing pneumonia

Tsai, Yueh-Feng; Ku, Yee-Huang

doi:10.1097/mcp.0b013e3283521022

Cited by 93 publications

(75 citation statements)

References 27 publications

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“…S. aureus necrotizing pneumonia is a rare clinical entity that is rapidly progressive and hemorrhagic and is associated with severe leukopenia and high mortality (24). It is often caused by S. aureus strains that produce LukSF-PV, most notably CA-MRSA strains, even in young, immunocompetent patients, typically after presenting with flu-like symptoms (25).…”

Section: Figmentioning

confidence: 99%

Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin

Diep

Visram

et al. 2016

Antimicrob Agents Chemother

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b Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), especially the USA300 pulsotype, is a frequent cause of skin and soft tissue infections and severe pneumonia. Despite appropriate antibiotic treatment, complications are common and pneumonia is associated with high mortality. S. aureus strains express multiple cytotoxins, including alpha-hemolysin (Hla) and up to five bicomponent leukocidins that specifically target phagocytic cells for lysis. CA-MRSA USA300 strains carry the genes for all six cytotoxins. Species specificity of the leukocidins greatly contributes to the ambiguity regarding their role in S. aureus pathogenesis. We performed a comparative analysis of the leukocidin susceptibility of human, rabbit, and mouse polymorphonuclear leukocytes (PMNs) to assess the translational value of mouse and rabbit S. aureus models. We found that mouse PMNs were largely resistant to LukSF-PV, HlgAB, and HlgCB and susceptible only to LukED, whereas rabbit and human PMNs were highly sensitive to all these cytotoxins. In the rabbit pneumonia model with a USA300 CA-MRSA strain, passive immunization with a previously identified human monoclonal antibody (MAb), Hla-F#5, which cross-neutralizes Hla, LukSF-PV, HlgAB, HlgCB, and LukED, provided full protection, whereas an Hla-specific MAb was only partially protective. In the mouse USA300 CA-MRSA pneumonia model, both types of antibodies demonstrated full protection, suggesting that Hla, but not leukocidin(s), is the principal virulence determinant in mice. As the rabbit recapitulates the high susceptibility to leukocidins characteristic of humans, this species represents a valuable model for assessing novel, cytotoxin-targeting anti-S. aureus therapeutic approaches.

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Section: Figmentioning

confidence: 99%

Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin

Diep

Visram

et al. 2016

Antimicrob Agents Chemother

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“…It is characterised by progressive necrosis of lung parenchyma with cavitating foci evident upon radiological investigation. The presenting symptoms of this case mirror those most commonly associated with NP: fever, chest pain, dyspnoea and cough 1. Clinically, NP can ultimately progress into respiratory failure, sepsis and death.…”

Section: Discussionmentioning

confidence: 64%

“…The most common of these are S. aureus , Streptococcus pneumoniae and Klebsiella pneumoniae 1. In children, S. pneumoniae is found most frequently 3.…”

Section: Discussionmentioning

confidence: 99%

Necrotising pneumonia caused by non-PVLStaphylococcus aureuswith 2-year follow-up

Hilton¹,

Tavare

Creer

2017

BMJ Case Reports

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Necrotising pneumonia (NP) is a rare but life-threatening complication of pulmonary infection. It is characterised by progressive necrosis of lung parenchyma with cavitating foci evident upon radiological investigation. This article reports the case of a 52-year-old woman, immunocompetent healthcare professional presenting to Accident and Emergency with NP and septicaemia. The cavitating lesion was not identified on initial chest X-ray leading to a delay in antimicrobial optimisation. However, the patient went on to achieve a full symptomatic recovery in 1 month and complete radiological recovery at 2-year follow-up. Long-term prognosis for adult cases of NP currently remains undocumented. This case serves as the first piece of published evidence documenting full physiological and radiological recovery following appropriate treatment of NP in an immunocompetent adult patient.

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“…Necrotizing pneumonia was determined to be present based on an adaptation of the criteria described by Tsai and Ku (37): typical radiographic features detected on a contrast-enhanced chest computed tomography scan, and pneumonic consolidation plus the presence of a cavity or multiple areas of low attenuation.…”

Section: Methodsmentioning

confidence: 99%

Community‐Associated Methicillin‐Resistant Staphylococcus aureus Necrotizing Pneumonia without Evidence of Antecedent Viral Upper Respiratory Infection

Toro

Janvier

Zhang

et al. 2014

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Pneumonia caused by community-associated methicillin-resistant Staphylococcus aureus is frequently complicated and severe, with a high mortality rate. This case series describes a group of patients with necrotizing pneumonia caused by community-associated methicillin-resistant Staphylococcus aureus who were treated at three hospitals in Calgary, Alberta. Laboratory results and clinical outcomes are described.

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Necrotizing pneumonia

Cited by 93 publications

References 27 publications

Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin

Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin

Necrotising pneumonia caused by non-PVLStaphylococcus aureuswith 2-year follow-up

Community‐Associated Methicillin‐Resistant Staphylococcus aureus Necrotizing Pneumonia without Evidence of Antecedent Viral Upper Respiratory Infection

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