Necrotizing pseudotumoral hepatic brucelloma: Imaging-pathologic correlation

Moigne, F. Le; Vitry, T.; Gérôme, P.; Vinurel, Nicolas; Ducerf, C.; Rode, Agnès; Bancel, Brigitte

doi:10.1016/j.diii.2014.08.007

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Meanwhile, derangement of liver biochemistry is usually minor. Granulomatous hepatitis, diffuse hepatitis without granuloma, focal necrosis and rarely liver abscess (brucelloma) have been rarely reported [42]. Radiologically, two main patterns were recognized; solitary abscesses involving liver (Figure 6) and multiple smaller abscesses, with frequent splenic affection, and absence of calcifications characterize the second pat tern [43,44].…”

Section: X-ray Images Showed Multiple Cystic Low Density Areas (Blue ...mentioning

confidence: 99%

Brucellosis as a Multisystem Disease

Mokhtar,

Albalawi,

M. Fallatah

2024

Current Topics in Zoonoses

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Brucellosis, one of the common zoonotic diseases all over the world, is still underdiagnosed. Under diagnosis is mostly due to certain concepts that should be revised especially in endemic areas. First of all, in endemic areas especially raw milk consuming communities, it is not logic to consider brucellosis only in certain occupations, while the whole community is exposed through utilization of non-pasteurized dairy products. Unawareness about the protean manifestations of brucellosis and its ability to affect almost every system in the body from heal to crown is another problem that needs orientation. Brucellosis now is one of the great imitators like SLE and TB. Chronic brucellosis can present by different manifestations even in the absence of fever and with low serum antibody titers. So, physicians in endemic areas should be aware by the usual and unusual presentations of brucellosis and should consider brucellosis in the differential diagnosis of almost every unexplained medical problem until proved otherwise.

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Section: X-ray Images Showed Multiple Cystic Low Density Areas (Blue ...mentioning

confidence: 99%

Brucellosis as a Multisystem Disease

Mokhtar,

Albalawi,

M. Fallatah

2024

Current Topics in Zoonoses

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“…Infection is usually detected by lymphocytic exudate, which may be related to the immune response of the abdominal mononuclear phagocytic system (Kantarcȩken et al, 2005). In brucellosis combined with liver abscess, patients may present with intermittent fever, nausea, vomiting, right upper abdominal pain, and right upper abdominal peritoneal irritation on examination (Le Moigne et al, 2016). Patients with concurrent splenic abscess often have fever, arthralgia, and persistent dull pain in the left upper abdomen.…”

Section: Digestive Systemmentioning

confidence: 99%

Research progress on complications of Brucellosis

Jun

Fan

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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Brucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, loss of appetite, weight loss, and enlarged liver, spleen and lymph nodes. The disease has a long and recurrent course, often accumulating in multiple systems and organs. Of these, osteoarticular involvement is the most common complication, with a prevalence of approximately 2-77%, usually manifesting as spondylitis, sacroiliac arthritis and peripheral arthritis. Hepatosplenomegaly is seen in about 50% of patients with brucellosis, and gastrointestinal disturbances such as abdominal pain, nausea, and vomiting are common. Although respiratory involvement is less common, pneumonia, pleurisy, pleural effusion, and pulmonary nodules have been reported. Besides, approximately 2-20% of cases involve infections of the male genitourinary system, mainly manifesting as unilateral epididymal-orchitis and orchitis. The most serious complication facing brucellosis is cardiovascular involvement, and although the overall mortality rate of brucellosis is about 1% and the incidence of brucellosis endocarditis is less than 2%, more than 80% of deaths are associated with endocarditis. Furthermore, brucellosis is complicated by hematologic disease, with anemia occurring in approximately 20-53% of children during the acute phase. In addition, the neurological incidence of brucellosis is about 0.5-25%, mainly manifested as meningitis. In this study, we review the multisystem complications of brucellosis with the aim of improving early diagnosis, timely treatment and prevention of long-term complications.

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“…Infectious diseases of the liver are other examples of the wide spectrum of non-genetic rare diseases as well as rare manifestations of common diseases. Infections such as brucellosis [29][30][31][32][33] or leishmaniosis 34 are rare in Europe -so is schistosomiasis, which on a world-wide scale is one of the most common infectious diseases and one of the most common liver diseases we know. Furthermore, hepatitis E infection appears to be very common in Europe, with a seroprevalence for anti-HEV antibodies estimated to be around 10-20%.…”

Section: How Common Is Rare?mentioning

confidence: 99%

Access to care in rare liver diseases: New challenges and new opportunities

Jones

Sturm

Lohse

2018

Journal of Hepatology

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Patients with rare diseases are often disadvantaged, particularly those with rare liver diseases. Reasons for disadvantage include delayed or overlooked diagnosis, lack of local expertise and high-quality care, poor scientific understanding of the disease process and limited therapeutic options. In adult liver disease this can be compounded by prejudices towards patients with liver disease in general, because of a perception (incorrect for all rare liver diseases) that liver disease is lifestyle related and thus "self-inflicted". In paediatric rare liver diseases, such as biliary atresia, optimising outcomes requires a particularly timely diagnosis. Irrespective of patient age, the scientific and medical community must rise to the challenge of advancing our understanding of rare liver disease, searching for more effective and specific therapies, and providing the infrastructure to provide the best care for all patients, infants, children, young and older adults. The European Reference Network for Rare Liver Diseases is an important step in this direction.

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Necrotizing pseudotumoral hepatic brucelloma: Imaging-pathologic correlation

Cited by 5 publications

References 6 publications

Brucellosis as a Multisystem Disease

Brucellosis as a Multisystem Disease

Research progress on complications of Brucellosis

Access to care in rare liver diseases: New challenges and new opportunities

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