Necrotizing Sialometaplasia: Literature Review and Case Reports

Necrotizing sialometaplasia of palate: a case report

“…Moreover, according to Imbery and Edwards, squamous metaplasia of the salivary ducts and coagulation necrosis of the acini is observed in early lesions and reactive fibrosis during the late stage of NS. [6]. Necrosis of the glandular acini predominates in the infarct stage.…”

“…Although the exact etiology of NS is not fully resolved, the lesion is believed to be related to a physicochemical or biological injury on the blood vessels that would produce ischemic changes, leading to infarction of the salivary gland acini with posterior necrosis, inflammation and intent of repairing, inducing metaplasia, changes in ducts, and further cicatrization [6]. Usually a local trauma like those produced by intubation, local anesthesia, surgery procedures, use of unadapted dental prothesis, violent or induced vomiting like in patients with bulimia, infectious processes, radiotherapy, and use of tobacco or cocaine, due to its constrictor effect, could be the factors involved in local ischemia [7].…”

“…Pseudoepitheliomatous hyperplasia could develop during the healing process of ulceration. However, if the infarct is limited in its extent, then sequestration and ulceration do not occur, and necrosis might occur just in a small portion [6].…”

“…The repair of ductal epithelium and acini by squamous metaplasia with accompanying pseudoepitheliomatous hyperplasia can actually be mistaken microscopically with mucoepidermoid carcinoma or squamous cell carcinoma [6]. It should be emphasized that these lesions also affect adults and children as well as in NS [2].…”

Forma cística da sialometaplasia necrosante em glândula salivar sublingual

“…Toda a lesão foi ressecada e enviada para exame anatomopatoló-gico. 10 , lábio inferior 11,12 , mucosa oral 8 , assoalho da boca 8 , língua 13 e glândulas salivares maiores 14,15 . A idade de apresentação nos quase 150 casos relatados na literatura variava entre 14 e 83 anos, sendo que, na maioria dos pacientes, a lesão foi diagnosticada durante a 5 a e 6 a décadas de vida 11 .…”