Necrotizing soft-tissue infections

Kuncir, Eric; Tillou, Areti; Hill, Charles R. St.; Petrone, Patrizio; Kimbrell, Brian; Asensio, Juan A.

doi:10.1016/s0733-8627(03)00089-0

Cited by 39 publications

(26 citation statements)

References 27 publications

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“…So thus, this study supports that of work by Bosshordt, McHenry CR, Lille St, Elliot DC and Sudersky LA. 19 In case of Fournier's gangrene alcoholism is account for 22% of cases which is slightly below than that of Smith study. This lower percentage may due to lower intake of alcohol consumption in our study population or may due to false history given by patient himself.…”

Section: Addictionmentioning

confidence: 64%

Clinicopathology study of necrotizing fasciitis with special reference to Fournier’s gangrene

Brar¹,

Dhaliwal²,

Singh³

et al. 2017

Int Surg J

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Background: Necrotizing fasciitis including Fournier’s gangrene is an uncommon, critically serious infection of the subcutaneous tissue and fascia with relative sparing of the skin and muscle. Despite modern supportive measures, the reported mortality rate still is high and this is due to part to the aggressive nature of the infection. The present study was performed upon 50 patients to study clinicopathology of necrotizing fasciitis with special reference to Fournier’s gangrene. Methods: This cross-sectional study was conducted in Surgery ward of SGRD Hospital, for a period of 1 year (1st January 2015 to 31st December 2015). The performa filled for patients with necrotizing fasciitis was designed on the basis of NICE guidelines and details like history, examination, general survey, local examination, systemic examination and investigations, statistical analysis of data done. Results: Necrotizing fasciitis, though it is found at any age but is a disease of middle and old aged adults in this part of the world, being commonest in the 4th, 5th, 6th decades of life and is more common in males. The disease is more common in people with low socio-economic groups with poor personal hygiene, diabetes mellitus and history of drug addiction. Trauma is the most common predisposing factor for the necrotizing fasciitis as a whole whereas idiopathic cause is the most common cause in cases of Fournier’s gangrene. Polymicrobial infection is the most common variety, where in E. coli, Streptococcus, Bacteroids are most commonly isolated. Regarding monobacterial infection streptococcus being the most common. Conclusion: Current study showed increased frequency of necrotizing fasciitis in people aged above 40 years. Diabetes mellitus and other premorbid conditions increase the risk of mortality. Polymicrobial infection in combination of Escherichia coli, Streptococcus, Pseudomonas, Bacteroids and Staphylococcus were the most commonly found. Early debridement, parenteral combined antibiotic and supportive measure formed the basis of treatment. Septicemia was a common complication which was often cause death.

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Section: Addictionmentioning

confidence: 64%

Clinicopathology study of necrotizing fasciitis with special reference to Fournier’s gangrene

Brar¹,

Dhaliwal²,

Singh³

et al. 2017

Int Surg J

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“…1 There are no reliable data on its true incidence in the population. 2 The origin is odontogenic in most cases, resulting from dental abscesses, chronic periodontal disease, or pharyngeal diseases. It progresses by forming extensive necrosis and gas in subcutaneous tissues and the underlying fascia, and has a high mortality rate (about 40%).…”

Section: Introductionmentioning

confidence: 99%

“…It progresses by forming extensive necrosis and gas in subcutaneous tissues and the underlying fascia, and has a high mortality rate (about 40%). 2 This disease is usually polymicrobial; such cases may be classified into type I, when caused by a mixed flora consisting of obligate anaerobic bacteria and other facultative anaerobic organisms not belonging to group A, and type II, when group A Streptococcus singly or with Staphylococcus aureus is involved. 3 Risk factors for NF are uncontrolled diabetes mellitus, peripheral vascular disease, liver diseases, and immune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…3 Risk factors for NF are uncontrolled diabetes mellitus, peripheral vascular disease, liver diseases, and immune diseases. 2 Imaging is essential to define the topography of the infection; the differential diagnosis is made mostly with cellulitis and initial stage erysipela. 4 Successful treatment requires an early diagnosis, radical surgical debridement of all necrotic tissues, endovenous broadspectrum antibiotic therapy, and aggressive general support measures.…”

Section: Introductionmentioning

confidence: 99%

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Fasceíte necrosante cérvico-torácica facial odontogênica

Júnior¹,

Melo²,

Oliveira³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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“…2 Hospital Carlos Haya. 4 Hospital Costal del Sol (Marbella). 3 Hospital Clínico Universitario Virgen de la Victoria.…”

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Características clínicas, epidemiológicas y factores asociados a mortalidad en los pacientes hospitalizados por infecciones de piel y partes blandas: Resultados del estudio multicéntrico STIMG (Soft Tissue Infections Malacitan Group)

Ordóñez¹,

Jiménez²,

Conde

et al. 2006

An. Med. Interna (Madrid)

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Ramos Cantes C, Martín Pérez M. Características clínicas, epidemiológicas y factores asociados a mortalidad en los pacientes hospitalizados por infecciones de piel y partes blandas. Resultados del estudio multicéntrico STIMG (Soft Tissue Infections Malacitan Group). An Med Interna (Madrid) 2006; 23: 310-316. RESUMENObjetivos: Describir las características de los pacientes hospitalizados con infecciones de piel y partes blandas (IPPB) y analizar las variables de los que fallecen durante el ingreso para definir grupos de riesgo.Metodo: Análisis retrospectivo de las historias clínicas de todos los pacientes que fueron dados de alta con IPPB durante el año 2002, en los hospitales públicos de la provincia de Málaga. Se excluyen infecciones secundarias a pie diabético, cirugía, quemados, úlceras por decúbito y la celulitis orbitaria. Se analizaron variables clínicas, bioquímicas, indicación y validez diagnóstica de pruebas microbiológicas y de imagen, así como el tratamiento antibiótico empírico iniciado y su correlación con las recomendaciones terapéuticas establecidas.Resultados: Analizamos 391 ingresos de 374 pacientes. La celulitis fue el diagnóstico más frecuente (69,3%). Se realizaron pruebas de imagen en el 51,6% de los casos. El antibiótico más empleado fue la amoxicilina con ácido clavulánico (39%). Fallecieron 27 (6,7%), el 40,7% por el proceso séptico en sí. Todos los fallecidos, tenían algún tipo de enfermedad crónica asociada. Las únicas variables analíticas que se asociaron de forma significativa a mayor mortalidad fueron las proteínas totales (55 ± 9 g/L vs. 63 ± 8 g/L; p = 0,0231) y los concentraciones séricas de albúmina (22 ± 7 g/L vs. 29 ± 7 g/L; p = 0,0125).Conclusiones: Las celulitis es la IPPB que mayor número de ingresos genera en nuestro medio. Apreciamos una sobreutilización de pruebas de imagen y una desviación sobre las recomendaciones terapéuticas y el tratamiento aplicado en nuestros hospitales. La mortalidad global observada es baja y afecta de manera exclusiva a pacientes con mal estado nutricional al ingreso, enfermedades crónicas o infecciones profundas. proteins and albumina (55 ± 9 g/L vs. 63 ± 8 g/L; p = 0.0231) and (22 ± 7 g/L vs. 29 ± 7 g/L; p = 0.0125)

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Necrotizing soft-tissue infections

Cited by 39 publications

References 27 publications

Clinicopathology study of necrotizing fasciitis with special reference to Fournier’s gangrene

Clinicopathology study of necrotizing fasciitis with special reference to Fournier’s gangrene

Fasceíte necrosante cérvico-torácica facial odontogênica

Características clínicas, epidemiológicas y factores asociados a mortalidad en los pacientes hospitalizados por infecciones de piel y partes blandas: Resultados del estudio multicéntrico STIMG (Soft Tissue Infections Malacitan Group)

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