Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery

Lipof, Jason S; Beck, Lisa A.; Reddy, Swapna C.; Southgate, Richard D.; Carney-Young, Kimberly; Hammert, Warren C.

doi:10.1016/j.jhsa.2017.08.019

Cited by 17 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pathergy is another prominent feature of NSS, in which intradermal trauma results in a nonspecific inflammatory response. Thus, surgical debridement, the first-line treatment for NF, can cause new lesion development and exacerbation of NSS [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Unlike NF, NSS responds well to steroids [ 9 ]. In one case of NSS mistaken for NF, repeated debridement worsened the patient's inflammatory markers, fevers, and leukocytosis and resulted in a fifth digit amputation [ 8 ]. In a study of 48 patients with necrotizing dermatoses, involvement of dermatologist prevented three unnecessary amputations [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

et al. 2022

View full text Add to dashboard Cite

Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precursors to developing SS. Here, we present a case of acute myeloid leukemia-associated NSS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It is characterized by hyperpyrexia, neutrophilia and painful skin lesions that can be single or multiple, be vesicular, pustular, bullous or ulcerative, and mainly necrosis. 12 The term Necrotizing SS proposed in 2012 and to date only 4 cases have been reported worldwide, in which patients had concealed hematological diseases and histopathological findings with necrosis of the fascia and fat, simulating necrotizing fasciitis. Previous cases were males with a median age of 57.5 years of onset, all of them with underlying hematological diseases, however the present case was in a very young woman with an aggressive clinical course.…”

Section: Discussionmentioning

confidence: 99%

Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing sweet syndrome

et al. 2021

View full text Add to dashboard Cite

The Sweet’s syndrome, is an inflammatory skin disorder characterized by extensive infiltration of neutrophils in the dermis with extension to the subcutis, known as acute febrile neutrophilic dermatosis. It may occur as a paraneoplastic syndrome. To our knowledge, there are currently few reports about transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet syndrome in the literature. Herein we describe an unusual case in a young patient with these characteristics that evolved to a fatal outcome.

show abstract

“…Several cases of NND misdiagnosed as NF have been reported in the dermatologic literature [ 2 , 6 , 18 , 19 ]. A case series involving 54 patients with NND revealed that 94% were initially given a diagnosis of NF [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Necrotizing neutrophilic dermatosis: A diagnostic challenge with a need for multi-disciplinary recognition, a case report

Gowda

Christensen

Polly

et al. 2020

Annals of Medicine and Surgery

View full text Add to dashboard Cite

Introduction Necrotizing neutrophilic dermatoses can clinically resemble necrotizing fasciitis and therefore pose a diagnostic and therapeutic challenge. Given their similar presentations, misdiagnosis and inappropriate or delayed treatments are possible. Presentation of case We discuss the case of a woman with acute myeloid leukemia who presented with fevers, chills, cough, and a leg wound. She underwent amputation of her lower extremity after she was presumed to have necrotizing fasciitis; however, symptoms persisted. She was ultimately diagnosed with and treated for necrotizing Sweet's syndrome with notable clinical improvement. Discussion Both, necrotizing neutrophilic dermatoses and necrotizing fasciitis, grossly affect the skin and are associated with rapidly progressing systemic features including fevers, chills, leukocytosis, and elevated inflammatory markers. Recent literature in dermatology addresses these similarities and the appropriate approach to management; however, it is critical that medical and surgical subspecialties have an understanding of necrotizing neutrophilic dermatoses and their clinical presentations, diagnostic approaches, as well as therapeutic interventions. Familiarity with this entity can mitigate the risk of misdiagnosis, morbidity, and mortality. Conclusion With this report, we seek to review the features that are suggestive of and aid in the diagnosis of necrotizing neutrophilic dermatoses to help prevent significant and avoidable morbidity.

show abstract

Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery

Cited by 17 publications

References 5 publications

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing sweet syndrome

Necrotizing neutrophilic dermatosis: A diagnostic challenge with a need for multi-disciplinary recognition, a case report

Contact Info

Product

Resources

About