Needle‐based confocal laser endomicroscopy for real‐time granuloma detection

Kramer, Tess; Wijmans, Lizzy; van Heumen, Saskia; Bansal, Sandeep; Jeannerat, Dawn; Manley, Christopher; de Bruin, Martijn; Bonta, Peter I.; Annema, Jouke T.

doi:10.1111/resp.14542

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…An advantage proposed for nCLE is that TIL is further refined by needle-based imaging at the tip of the needle (needle-in-target). Alongside previous reports on PPN, K ramer and co-workers [ 5 , 6 ] presented an observational study on nCLE, evaluating its performance in the diagnosis of granulomatous diseases.…”

Section: Group 1401: Interventional Pulmonologymentioning

confidence: 99%

ERS International Congress 2023: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly

Moretti,

Pietersen,

Hassan

et al. 2023

ERJ Open Res

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The Clinical Techniques, Imaging and Endoscopy Assembly is involved in the diagnosis and treatment of several pulmonary disease as demonstrated at the 2023 ERS International Congress in Milan (figure 1).From interventional pulmonology, the congress included several exciting results for the use of bronchoscopy in lung cancer including augmented fluoroscopy, robotic assisted bronchoscopy and cryobiopsies. In obstructive lung disease bronchoscopic treatment of emphysema with hyperinflation and chronic bronchitis were presented with the latest results. Research on use of cryobiopsies for the diagnosis of interstitial lung disease was further explored, aiming to elevate diagnostic yield and minimize risk.For imaging the latest updates in artificial intelligence is of great interest as a way to overcome the increased work-load for the radiologist. Novel imaging in sarcoidosis explored the use of MRI, photon counting CT and PET-CT in the diagnostic work-up. Lung cancer screening is still a hot topic and new results regarding incorporation of biomarkers, identifying knowledge gaps and improving the screening programs were presented.The use of ultrasound in respiratory medicine is an expanding field demonstrated by the large variety in studies presented at this year's congress. Ultrasound of the diaphragm in patients with ALS and myasthenia gravis was used to assess movements and predict respiratory fatigueness. Furthermore studies using ultrasound to diagnosis or monitor pulmonary disease were presented. The congress also included studies regarding the training and assessment of competencies as an important part of implementing ultrasound in clinical practice.

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Section: Group 1401: Interventional Pulmonologymentioning

confidence: 99%

ERS International Congress 2023: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly

Moretti,

Pietersen,

Hassan

et al. 2023

ERJ Open Res

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Imaging modalities during navigational bronchoscopy

Abdelghani,

Omballi,

Abia-Trujillo

et al. 2024

Expert Review of Respiratory Medicine

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Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial)

van Heumen,

Kramer,

Korevaar

et al. 2024

BMJ Open

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Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving the sampling location and diagnostic yield. Previous studies have defined and validated nCLE criteria for malignancy, airway and lung parenchyma. Larger studies demonstrating the effect of nCLE on diagnostic yield are lacking. We aim to investigate if nCLE-imaging integrated with conventional bronchoscopy results in a higher diagnostic yield compared with conventional bronchoscopy without nCLE. Methods and analysis This is a parallel-group randomised controlled trial. Recruitment is performed at pulmonology outpatient clinics in universities and general hospitals in six different European countries and one hospital in the USA. Consecutive patients with a for malignancy suspected peripheral lung nodule (10–30 mm) with an indication for diagnostic bronchoscopy will be screened, and 208 patients will be included. Web-based randomisation (1:1) between the two procedures will be performed. The primary outcome is diagnostic yield. Secondary outcomes include diagnostic sensitivity for malignancy, needle repositionings, procedure and fluoroscopy duration, and complications. Pathologists will be blinded to procedure type; patients and endoscopists will not. Ethics and dissemination Primary approval by the Ethics Committee of the Amsterdam University Medical Center. Dissemination involves publication in a peer-reviewed journal. Support Financial and material support from Mauna Kea Technologies. Trial registration number NCT06079970 .

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Needle‐based confocal laser endomicroscopy for real‐time granuloma detection

Cited by 4 publications

References 24 publications

ERS International Congress 2023: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly

ERS International Congress 2023: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly

Imaging modalities during navigational bronchoscopy

Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial)

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