Needle-free delivery of fluids from compact laser-based jet injector

Krizek, Jan; Goumoëns, Frédéric De; Delrot, Paul; Moser, Christophe

doi:10.1039/d0lc00646g

Cited by 21 publications

(10 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These volumes are typically injected at different penetration depths, ranging from hundreds of microns to tens of millimeters (Figure 19): II). c) Penetration depth (mm) of the transdermal drug delivery systems summarized in subsections 4.1-4.4: jet injector, 39,115,[177][178][179][180][181][182][183][184][185] microjet, 39,135,137,170 microneedles [186][187][188][189][190][191][192][193][194] and tattooing. 170,[195][196][197] There is mounting evidence that intradermal delivery (ID) of vaccines increases the effectiveness of these procedures, which traditionally are done either intramuscular (IM) or subcutaneous (subC).…”

Section: -Discussionmentioning

confidence: 99%

“…b) Maximum penetration depth (mm) of the imaging techniques described in Section 2 (References can be found in TableII). c) Penetration depth (mm) of the transdermal drug delivery systems summarized in subsections 4.1-4.4: jet injector,39,115,[177][178][179][180][181][182][183][184][185] microjet,39,135,137,170 microneedles[186][187][188][189][190][191][192][193][194] and tattooing 170,[195][196][197]. SC: Stratum corneum, E: Epidermis, D: Dermis, H: Hypodermis (i.e.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Challenges and opportunities for small volumes delivery into the skin

Mercuri

Rivas

2021

Biomicrofluidics

View full text Add to dashboard Cite

Each individual's skin has its own features, such as strength, elasticity or permeability to drugs, which limits the effectiveness of one-size-fits-all approaches typically found in medical treatments. Therefore, understanding the transport mechanisms of substances across the skin is instrumental for the development of novel minimal invasive transdermal therapies. However, the large difference between transport timescales and length-scales of disparate molecules needed for medical therapies makes it difficult to address fundamental questions. Thus, this lack of fundamental knowledge has limited the efficacy of bioengineering equipment and medical treatments. In this article we provide an overview of the most important microfluidics-related transport phenomena through the skin and versatile tools to study them. Moreover, we provide a summary of challenges and opportunities faced by advanced transdermal delivery methods, such as needle-free jet injectors, microneedles and tattooing, which could pave the way to the implementation of better therapies and new methods.

show abstract

Section: -Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Challenges and opportunities for small volumes delivery into the skin

Mercuri

Rivas

2021

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

“…In order to overcome the aforementioned limitations and improve the controllability of liquid jet injection, it is necessary to precisely control the pressure profile exhibited by the liquid jet. Among more recently proposed concepts to drive needle-free liquid injectors, such as: the use of a single piezoelectric crystal [29] or a piezoelectric crystal stack [30] to actuate a piston, expansion of vapor bubbles using laser radiation [31][32][33][34][35][36][37], electrical current discharge [38], and pyrotechnics [39], it seems that electronic linear actuators provide one of the most practical and efficient methods for complete closed-loop control of liquid jet production. They offer real-time control and do not require high voltages or subject the fluid to electric charges or laser radiation as in other experimental techniques.…”

Section: Introductionmentioning

confidence: 99%

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

Portaro

2022

Applied Sciences

View full text Add to dashboard Cite

The current state of commercially available needle-free liquid jet injectors for drug delivery offers no way of controlling the output pressure of the device in real time, as the driving mechanism for these injectors provides a fixed delivery pressure profile. In order to improve the delivery efficiency as well as the precision of the targeted tissue depth, it is necessary to develop a power source that can accurately control the plunger velocity. The duration of a liquid jet injection can vary from 10 to 100 ms, and it generate acceleration greater than 2 g (where g is the gravity); thus, a platform for real-time control must exhibit a response time greater than 1 kHz and good accuracy. Improving the pioneering work by Taberner and others whereby a Lorentz force actuator based upon a voice coil is designed, this study presents a prototype injector system with greater controllability based on the use of a fully closed-loop control system and a classical three-phase linear motor consisting of three fixed coils and multiple permanent magnets. Apart from being capable of generating jets with a required stagnation pressure of 15–16 MPa for skin penetration and liquid injection, as well as reproducing typical injection dynamics using commercially available injectors, the novelty of this proposed platform is that it is proven to be capable of shaping the real-time jet injection pressure profile, including pulsed injection, so that it can later be tailored for more efficient drug delivery.

show abstract

“…Laser-induced underwater shock waves [1,2] are widely used in clinical medicine for various techniques, such as needle-free injection [3,4,5,6,7], lithotripsy [8,9], skull base tumor removal [10], and treatment of diseases such as femoral head osteonecrosis [11,12,13], osteochondritis dissecans [14], osteochondral lesions ( [15]), and bone marrow edema [16]. These techniques have the advantage that incisions are not necessary, and thus there is a lower risk of complications developing [17,12].…”

Section: Introductionmentioning

confidence: 99%

Background-oriented Schlieren technique with vector tomography for measurement of axisymmetric pressure fields of laser-induced underwater shock waves

Ichihara¹,

Shimazaki²,

Tagawa³

2022

Preprint

View full text Add to dashboard Cite

This study aims to overcome the problems that existing background-oriented schlieren (BOS) techniques based on computed tomography (CT-BOS) face when measuring pressure fields of laser-induced underwater shock waves. To do this, it proposes a novel BOS technique based on vector tomography (VT-BOS) of an axisymmetric target. The remarkable feature of the proposed technique is the reconstruction of an axisymmetric vector field with nonzero divergence, such as the field of a laser-induced underwater shock wave. This approach is based on an approximate relation between the projection of the axisymmetric vector field and the reconstructed vector field. For comparison, the pressure fields of underwater shock waves are measured with VT-BOS, CT-BOS, and a needle hydrophone. It is found that VT-BOS is significantly better than CT-BOS in terms of better convergence, less dependence on the spatial resolution of the acquired images, and lower computational cost. The proposed technique can be applied not only to fluid dynamical fields, but also to other axisymmetric targets in other areas, such as electromagnetics and thermodynamics.

show abstract

Needle-free delivery of fluids from compact laser-based jet injector

Abstract: Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Due to bulky actuation mechanisms, they are limited to body areas that...

Cited by 21 publications

References 55 publications

Challenges and opportunities for small volumes delivery into the skin

Challenges and opportunities for small volumes delivery into the skin

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

Background-oriented Schlieren technique with vector tomography for measurement of axisymmetric pressure fields of laser-induced underwater shock waves

Contact Info

Product

Resources

About