Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Li, Chunyu; Wang, Zhewei; Tu, Chen; Wang, Jiabo; Jiang, Bingqian; Li, Qi; Zeng, Ling-na; Ma, Zhi-Jie; Zhang, Ping; Zhao, Yongkun; Zhang, Yaming; Yan, Dan; Tan, Rui; Xiao, Xiaohe

doi:10.1631/jzus.b1400065

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Without the aid of needles, the liquid drug is ejected out from a small aperture at high speed (flow rate is generally greater than 100m/s) to reach the subcutaneous tissue with insulin distribution averagely higher than when a needle injection is used. This provides a very conducive area for maximal and complete absorption of insulin under the skin into bloodstream ( 12 ). In this study, a transient scanning glucose monitoring system was used to evaluate the effect of needle-free injection and needle injection within a 24-hour blood glucose fluctuations period in patients with early-onset type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus

Jin

Sun²,

Yue³

et al. 2023

Front. Endocrinol.

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ObjectiveTo explore the effect of using needle-free insulin syringe on blood sugar control and well-being index in patients with early-onset type 2 diabetes mellitus.MethodsA total of 42 patients with early-onset type 2 diabetes mellitus treated with insulin aspart 30 injection in a stable condition in the Endocrinology Department of a tertiary hospital from January 2020 to July 2021 were randomly divided into two groups, one group received insulin pen injections followed by needle-free injections, and the other group received needle-free injections followed by insulin pen injections. Transient scanning glucose monitoring was performed during the last two weeks of each injection modality phase. Comparison of the two injection methods in terms of test indicators and differences in injection site pain scores, the number of red spots on the skin at the injection site and the number of bleeding spots on the skin at the injection site.ResultsThe FBG of the needle-free injection group was lower than that of the Novo Pen group (p<0.05); the 2-hour postprandial blood glucose of the needle-free injection group was lower than that of the Novo Pen group, but there was no statistical significant difference. The amount of Insulin in the needle-free injector group was lower than that in the Novo pen group, but there was no statistical significant difference between the two groups. The WHO-5 score of the needle-free injector group was higher than that of the Novo Pen group(p<0.05); the pain score at the injection site was lower than that of the Novo Pen group (p<0.05). The number of skin red spots using the needle-free syringe was more than that of the Novo pen group(p<0.05); the number of skin bleeding at the site of injection was similar between the two injection methods.ConclusionCompared to traditional insulin pens, subcutaneous injection of premixed insulin using a needle-free syringe is effective in controlling fasting blood glucose in patients with early onset type 2 diabetes and is less painful at the injection site. In addition, blood glucose monitoring should be strengthened and insulin dosage should be adjusted in a timely manner.

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Section: Discussionmentioning

confidence: 99%

A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus

Jin

Sun²,

Yue³

et al. 2023

Front. Endocrinol.

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“…With a greater diverging channel angle, a substantial decrease in temperatures is caused by greater Reynolds numbers, and the reverse effect is computed for converging channels. The present model has neglected non-Newtonian properties 52 of the nanofluid and also transient effects 53,54…”

Section: Discussionmentioning

confidence: 99%

Multiple slip effects on nanofluid dissipative flow in a converging/diverging channel: A numerical study

Bég¹,

Bég

Khan

et al. 2021

Heat Trans

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A mathematical model is developed for viscous slip flow and heat transfer in water/Ethylene glycol-based nanofluids containing metallic oxide nanoparticles, through a converging/diverging channel. We adopt the single-phase Tiwari-Das model. The governing equations are transformed to a set of similarity differential equations with the help of similarity transformation, before being solved numerically using Maple 20. Validation of the velocity gradient and temperature solutions is achieved with the second-order implicit finite difference Keller Box method. Further validation is included for the special case of no-slip nanofluid flow in the absence of viscous heating. The effects of the parameters, namely velocity slip, thermal jump, channel apex angle, Eckert number, Prandtl number, Reynolds number, and nano-particle volume fraction on velocity, temperature, skin friction, and heat transfer rate are investigated in detail. It is found that with increasing velocity slip, for water-TiO 2 and ethylene glycol-TiO 2 nanofluids, the channel bulk flow is decelerated whilst with greater solid (nanoparticle) volume and in the presence of momentum slip, the flow is also retarded. With the increasing semivertex angle, the channel flow is generally accelerated. An increase in divergent semiangle leads to decelerate the flow from the centerline for the core flow region, whereas

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“…A new injection device without the needle called powder needleless injection (PNI) uses insulin powder to deliver it through the skin barrier. It has been proven that in this method, carriers could improve penetration while insulin powder without any carrier is not efficient enough . Insulin‐loaded AGMS, which were prepared as dry powder were also successfully used as nasal insulin therapy …”

Section: Strategies To Improve Non‐invasive Insulin Therapymentioning

confidence: 99%

“…It has been proven that in this method, carriers could improve penetration while insulin powder without any carrier is not efficient enough. [127] Insulin-loaded AGMS, which were prepared as dry powder were also successfully used as nasal insulin therapy. [64] Film: Films are drug delivery systems made of one or more types of polymers in thin sheet shape.…”

Section: Macro-formulationsmentioning

confidence: 99%

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Taraghdari

Imani

Mohabatpour

2019

Macromolecular Bioscience

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Diabetes mellitus (DM) is the most prevalent non‐contagious disease, which has affected a large number of people all over the world. Among all treatments known to have a positive influence in the control of DM, insulin therapy is the most common and effective one. Nowadays, various methods of insulin delivery are under investigation, which are able to reach a plausible bioavailability with ignorable side effects instead of insulin injection. This article presents a comprehensive review of the insulin therapy approach with a focus on modified methods in insulin delivery strategies and current advances in engineered insulin delivery systems.

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Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Cited by 8 publications

References 26 publications

A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus

A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus

Multiple slip effects on nanofluid dissipative flow in a converging/diverging channel: A numerical study

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

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