Needle-free injectors

Vadlapatla, Rajesh; Gayakwad, Sanjaykumar; Yellepeddi, Venkata K.; Wong, Eva

doi:10.1016/b978-0-12-819838-4.00002-x

Cited by 1 publication

(1 citation statement)

References 30 publications

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“…In fact, commercially available injectors that are capable of producing such pressure peaks can routinely deliver 0.1 to 1 mL of fluid at depths greater than 10 mm. For summary, a number of recent review articles on this technology and its state-of-the-art can be found in the literature, e.g., [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

Portaro

2022

Applied Sciences

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The current state of commercially available needle-free liquid jet injectors for drug delivery offers no way of controlling the output pressure of the device in real time, as the driving mechanism for these injectors provides a fixed delivery pressure profile. In order to improve the delivery efficiency as well as the precision of the targeted tissue depth, it is necessary to develop a power source that can accurately control the plunger velocity. The duration of a liquid jet injection can vary from 10 to 100 ms, and it generate acceleration greater than 2 g (where g is the gravity); thus, a platform for real-time control must exhibit a response time greater than 1 kHz and good accuracy. Improving the pioneering work by Taberner and others whereby a Lorentz force actuator based upon a voice coil is designed, this study presents a prototype injector system with greater controllability based on the use of a fully closed-loop control system and a classical three-phase linear motor consisting of three fixed coils and multiple permanent magnets. Apart from being capable of generating jets with a required stagnation pressure of 15–16 MPa for skin penetration and liquid injection, as well as reproducing typical injection dynamics using commercially available injectors, the novelty of this proposed platform is that it is proven to be capable of shaping the real-time jet injection pressure profile, including pulsed injection, so that it can later be tailored for more efficient drug delivery.

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Section: Introductionmentioning

confidence: 99%

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

Portaro

2022

Applied Sciences

View full text Add to dashboard Cite

show abstract

Needle-free injectors

Cited by 1 publication

References 30 publications

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

Design and Analysis: Servo-Tube-Powered Liquid Jet Injector for Drug Delivery Applications

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