Needle-Free Jet Injectors and Nanosuspensions: Exploring the Potential of an Unexpected Pair

Abstract

Needle-free liquid jet injectors are medical devices used to administer pharmaceutical solutions through the skin. Jet injectors generate a high-speed stream of liquid medication that can puncture the skin and deliver the drug to the underlying tissues. In this work, we investigated the feasibility of using liquid jet injectors to administer nanosuspensions, assessing the impact of the jet injection on their pharmaceutical and physicochemical properties. For this purpose, the model drug diclofenac was used to prepare a set of nanosuspensions, stabilized by poloxamer 188, and equilibrated at different pHs. The hydrodynamic diameter and morphology of the nanocrystals were analyzed before and after the jet injection across porcine skin in vitro, together with the solubility and release kinetics of diclofenac in a simulated subcutaneous environment. The efficacy of the jet injection (i.e., the amount of drug delivered across the skin) was evaluated for the nanosuspension and for a solution, which was used as a control. Finally, the nanosuspension was administered to rats by jet injector, and the plasma profile of diclofenac was evaluated and compared to the one obtained by jet injecting a solution with an equal concentration. The nanosuspension features were maintained after the jet injection in vitro, suggesting that no structural changes occur upon high-speed impact with the skin. Accordingly, in vivo studies demonstrated the feasibility of jet injecting a nanosuspension, reaching relevant plasma concentration of the drug. Overall, needle-free jet injectors proved to be a suitable alternative to conventional syringes for the administration of nanosuspensions.

Systematic Review: Teknologi Needle Free Jet Injection Insulin (NFJI) Efektif Mengontrol Konsentrasi Glukosa Pada Penderita Diabetes Melitus Tipe 2

“…Secara konvensional, NFJI paling sering digunakan untuk vaksinasi dan aplikasi pengiriman insulin (Mohizin & Kim, 2018) metode ini memanfaatkan injektor jet untuk menciptakan aliran insulin dalam jumlah kecil berkecepatan tinggi yang dapat menembus mukosa (Schlich et al, 2022) dan atau kulit tanpa menyebabkan trauma jaringan (Gupta, 2022).…”

Nanosuspension-Based Dissolvable Microneedle Arrays to Enhance Diclofenac Skin Delivery

“…When topically applied on the skin, the DCF nanocrystal formulation exhibited higher skin accumulation compared to the raw drug [ 8 ]. In an effort to enhance the effectiveness of the nanocrystal technology, DCF-NS were also combined with other devices to boost their delivery through the skin, such as microneedle rollers and a needle-free jet injector, resulting in the formation of drug nanocrystal depots [ 14 , 15 ]. A lot of interest has recently arisen around polymeric microneedles arrays (MNAs) as an alternative technology to enhance drug delivery and distribution through the skin [ 16 ].…”

Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications

“…Nanocrystals are usually manufactured as aqueous nanosuspensions and stabilized by ionic or non-ionic surfactants, polymers or a mixture of both. In order to enhance its permeation and absorption through the skin, aqueous DCF nanosuspensions have recently been administered in combination with medical devices, such as microneedle rollers [13] and needle-free jet injectors [14].…”