Neem - A Cynosure of Modern Medicine: A Review

Barman, Purabi; Ahmed, Nekibuddin; Chakraborty, Dipanjan

doi:10.5455/ijlr.20180807044809

Cited by 2 publications

(2 citation statements)

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“…[ 21 ] Cavitation could have led to the temporary weakening of the bacterial cell wall. [ 10 ] Thus, a synergistic action between the chemical effects of Neem with mechanical effects of UA resulted in enhanced antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial efficacy of two commercially available herbal products with and without ultrasonic activation in primary endodontic infections: A randomized clinical trial

Palwankar,

Garg,

Tandan

et al. 2024

Journal of Conservative Dentistry and Endodontics

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Background: Effective irrigation is crucial for successful endodontic treatment. Traditional irrigants like sodium hypochlorite (NaOCl) have been widely used, but there is a growing interest in exploring natural alternatives for their potential antimicrobial properties. Objective: The study aims to compare the antimicrobial efficacy of Neem, Bitter Gourd, and NaOCl, with and without ultrasonic activation in managing primary endodontic infections. Materials and Methods: Ninety patients were randomly assigned six groups (n = 15) Group 1: NaOCl, Group 2: NaOCl with passive ultrasonic irrigation (PUI), Group 3: Neem juice, Group 4: Neem juice with PUI, Group 5: Bitter gourd juice, and Group 6: Bitter gourd juice with PUI. Bacteriological samples were collected before (S1) and after (S2) shaping, plated on brain heart infusion agar, and colony counting was done after 24 h. Statistical Analysis Used: Shapiro–Wilk test, one-way ANOVA, post hoc Tukey analysis, and paired t-test. Results: All the groups demonstrated a significant reduction in bacterial count. Groups with PUI (2, 4, 6) demonstrated higher mean bacterial reduction than their counterparts without PUI (1, 3, 5). Conclusion: Neem and Bitter gourd juices, particularly when used with PUI, demonstrated antimicrobial efficacy comparable to NaOCl with PUI.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial efficacy of two commercially available herbal products with and without ultrasonic activation in primary endodontic infections: A randomized clinical trial

Palwankar,

Garg,

Tandan

et al. 2024

Journal of Conservative Dentistry and Endodontics

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“…7 Since the neem tree's parts have all been demonstrated to have some medicinal value, they can all be used for commercial purposes. 8 Numerous reviews on the chemistry and structural variety of these compounds have also been published. Countless chemicals have been extracted from various Neem components.…”

Section: Introductionmentioning

confidence: 99%

Neem (Azadirachta indica): A Panacea of all Diseases

Sidat,

Modh,

Chavda

et al. 2023

JOPCR

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Neem (Azadirachta indica) belongs to the Meliaceae family. Neem is well-known around the world for its medicinal and nutritional properties. Various parts of the plant like fruits, leaves, flowers, twigs, gum, seed, oil, bark, and root are known to have medicinal properties and are scientifically established for the various properties. Since ancient times, plant’s parts have been utilized for their medicinal value. The plant contains a high amount of catalase (CAT), peroxidase (POD), polyphenol oxidase (PPO) and ascorbate peroxidase (APX) enzyme, and many other phytoconstituents such as isoprenoid-containing protomeliacins, limonoids, azadirone and Csecomeliacins such as azadirachtin, nimbin, and salanin. The non-isoprenoids include sulphurous compounds, polyphenolics like flavonoids and their glycosides, dihydrochalcone, coumarin and tannins, proteins (amino acids) and carbohydrates (polysaccharides), as well as aliphatic compounds. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological applications. In this review article, we summarized the information regarding the various pharmacological activities of neem plants. All information presented in this review article regarding the beneficial application of Neem (Azadirachta indica) has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of Science, and PubMed. The Neem plant, including leaves, bark, latex, seed, and their active constituents, plays a significant part in the management of progressive illness. The neem plant contains active ingredients were accountable for the basketful therapeutic function such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antioxidant, antimicrobial, antimalarial, antifertility, and also helps in proper digestion, hair growth, skin related problems and relief in menstrual pain and many more. The main findings showed that neem has strong medicinal properties and is also useful in cosmetic applications. There is no evidence of adverse effects of neem in literature. Only the people who are allergic to it can have side effects otherwise it is stomach friendly in all conditions due to which it can be applicable for treatment of various health related disorders. Keywords: Neem (Azadirachta indica), Phytochemical constituents, Therapeutic application

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Neem - A Cynosure of Modern Medicine: A Review

Cited by 2 publications

References 0 publications

Antimicrobial efficacy of two commercially available herbal products with and without ultrasonic activation in primary endodontic infections: A randomized clinical trial

Antimicrobial efficacy of two commercially available herbal products with and without ultrasonic activation in primary endodontic infections: A randomized clinical trial

Neem (Azadirachta indica): A Panacea of all Diseases

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