Neem oil based nano-emulsion formulation by low energy phase inversion composition method: Characterization and antimicrobial activity

Safaya, Malvika; Rotliwala, Yogesh C.

doi:10.1016/j.matpr.2021.12.478

Cited by 9 publications

(11 citation statements)

References 37 publications

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“…Zeta potential measurements provide insights into particle stability, with values above 30 mV indicating minimal aggregation due to electrostatic repulsion. The negative zeta potential observed may be attributed to nonionic surfactants, promoting steric rather than electrostatic stabilisation [57]. Evaluating pH is crucial for monitoring formulation degradation.…”

Section: Discussionmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Borges,

Wolff,

da Silva

et al. 2024

CIMB

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This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography–mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.

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Section: Discussionmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Borges,

Wolff,

da Silva

et al. 2024

CIMB

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“…When dealing with the phase inversion temperature approach of nanoformation, non-ionic surfactants with temperature-dependent solubilities (such as poly-ethoxylated surfactants) are used. Adjusting the affinities of surfactants for water and oil as a function of temperature produces a fine nanoemulsion [41,42]. Polyethoxylated surfactants become lipophilic when heated because the polyoxyethylene groups dehydrate.…”

Section: Phase Inversion Temperaturementioning

confidence: 99%

“…It has been observed that instant cooling of the emulsion at the temperature of phase inversion can produce stable and fine emulsion droplets [44,45]. Safaya et al, prepared nanoemulsion of neem oil by adopting this method [42].…”

Section: Phase Inversion Temperaturementioning

confidence: 99%

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Rehman

Younas

Bano³

et al. 2022

Pak J Anal Environ Chem

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Nano-emulsion is one of the most effective and size-controlled mediums for effective drug delivery systems, the formation of cosmetics products, food preservatives, and insecticidal and antimicrobial products. Therefore, a durable and sophisticated approach is primely important in preparing effective nano-emulsions. Some of the established fabrication approaches towards nanoemulsion are the high and low-energy methods. Depending upon the required results of formulations, these two methods are further divided into sub-categories such as ultra-sonicators, micro-fluidizers, high-pressure homogenizers, phase inversion temperature, phase inversion composition, etc. This review highlights all the available methods to form nano-emulsion by adopting high-energy and low-energy techniques. In addition, this review also elaborates on the importance of nano-emulsions in various end products, as nano-carriers and patents have also been awarded in this field. Besides, the required improvements in this field have been discussed briefly to establish the most authentic approach toward nano-emulsion formation.

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“…Numerous scientific studies have demonstrated the antimicrobial and anti-inflammatory properties of natural oils, including lavender and neem [1][2][3][4]. Neem oil, derived from neem tree seeds, is a natural insecticide and organic fungicide with antimicrobial properties, effectively repelling pests and preventing fungal diseases in plants [1].…”

Section: Introductionmentioning

confidence: 99%

“…Neem oil is employed for traditional medicinal purposes, treating ailments such as fever and digestive issues. Its versatile uses make it a valuable addition to both natural medicine and sustainable agriculture [2,3]. Lavender oil, extracted from the lavender plant, has therapeutic properties and is used in aromatherapy, personal care, and natural cleaning products.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Polycaprolactone Nanofiber Coated with Lavender and Neem Oil Nanoemulsions against Airborne Bacteria

Rahman,

Kotturi,

Nikfarjam

et al. 2024

Membranes

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The development of efficient, eco-friendly antimicrobial agents for air purification and disinfection addresses public health issues connected to preventing airborne pathogens. Herein, the antimicrobial activity of a nanoemulsion (control, 5%, 10%, and 15%) containing neem and lavender oils with polycaprolactone (PCL) was investigated against airborne bacteria, including Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Various parameters such as the physicochemical properties of the nanoemulsion, pH, droplet size, the polydispersity index (PDI), the minimum inhibitory concentration (MIC), the minimum bacterial concentration (MBC), and the color measurement of the emulsion have been evaluated and optimized. Our results showed that the antimicrobial activity of PCL combined with neem and lavender oil was found to be the highest MIC and MBC against all tested bacteria. The droplet sizes for lavender oil are 21.86–115.15 nm, the droplet sizes for neem oil are 23.92–119.15 nm, and their combination is 25.97–50.22 nm. The range of pH and viscosity of nanoemulsions of various concentrations was found to be 5.8 to 6.6 pH and 0.372 to 2.101 cP. This study highlights the potential of nanotechnology in harnessing the antimicrobial properties of natural essential oils, paving the way for innovative and sustainable solutions in the fight against bacterial contamination.

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Neem oil based nano-emulsion formulation by low energy phase inversion composition method: Characterization and antimicrobial activity

Cited by 9 publications

References 37 publications

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Açaí (Euterpe oleracea Mart.) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Antimicrobial Activity of Polycaprolactone Nanofiber Coated with Lavender and Neem Oil Nanoemulsions against Airborne Bacteria

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