Nefropatia por IgA: análise histológica e correlação clínico-morfológica em pacientes do Estado de Minas Gerais

Neves, Precil Diego Miranda de Menezes; Machado, Juliana Reis; Silva, Marcos Vinícius da; Abate, Débora Tavares de Resende e Silva; Rodrigues, Denise Bertulucci Rocha; Faleiros, Ana Carolina Guimarães; Reis, Marlene Antônia dos

doi:10.1590/s0101-28002012000200001

Cited by 5 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The original Oxford Classification cohort demonstrated that mesangial hypercellularity, segmental sclerosis and endocapillary proliferation were histopathological variables associated with proteinuria (Working Group of the International IgA Nephropathy Network and the Renal Pathology Society et al 2009b ). Indeed, a trend towards higher 24-h proteinuria levels was observed in patients with mesangial hypercellularity (M1) which is similar to previous observations in Brazil, South Korea and Sweden (Neves et al 2012 ; Kang et al 2012 ; Halling et al 2012 ). This series however demonstrated that migration from a T0 to a T1 pattern was also associated with proteinuria.…”

Section: Discussionsupporting

confidence: 88%

“…However Wyatt and Julian ( 2013 ) reported hematuria during upper respiratory tract or gastrointestinal tract disease in 75 % of the North American patients. In this cohort patients presented at diagnosis with average 24-h proteinuria levels near the nephrotic range (3.27 g/24 h), higher than previous reports (Zeng et al = 1.3 g; Oxford = 1.7 g; Neves = 1.8 g; Moriyama = 1.19 g) (Working Group of the International IgA Nephropathy Network and the Renal Pathology Society et al 2009a , b ; Zeng et al 2012 ; Neves et al 2012 ; Moriyama et al 2014 ) but comparable to the data by Huerta et al ( 2011 ) (3.7 g). However the higher levels of proteinuria in our series and the frequency of nephrotic syndrome as initial presentation could be a result of biopsy indication bias.…”

Section: Discussionmentioning

confidence: 53%

“…It encompasses kidney samples obtained in 10 reference institutions located on the three most densely populated and ethnically diverse areas of the country (Northeast, 2 centres, 34 cases; Southeast, 6 centres, 458 cases; South, 2 centres, 108 cases). IgAN patients from—have a slight male predominance (55.4 %) as opposed to the Oxford Classification original cohort (72 %) (Working Group of the International IgA Nephropathy Network and the Renal Pathology Society et al 2009a ; b) and North American data (64 %) (Wyatt and Julian 2013 ) but in accordance with a Chinese (50 %) (Zeng et al 2012 ) and a previous national cohort (53.7 %) (Neves et al 2012 ). Patients were diagnosed with IgAN at the average age of 32.67 years old similarly as other reported series including the Oxford Classification cohort (Working Group of the International IgA Nephropathy Network and the Renal Pathology Society et al 2009b ; Zeng et al 2012 ).…”

Section: Discussionmentioning

confidence: 78%

See 2 more Smart Citations

IgA nephropathy in Brazil: apropos of 600 cases

et al. 2015

View full text Add to dashboard Cite

IgA nephropathy (IgAN) is th e commonest primary glomerular disease worldwide. Studies on its prevalence in Brazil are however scarce. Databases and clinical records from 10 reference centres were retrospectively reviewed. Clinical and laboratory features at the moment of the biopsy were retrieved (age, gender, presence of hematuria, serum creatinine [mg/dL], proteinuria [g/24 h]). Renal biopsy findings were classified according to Haas single grade classification scheme and the Oxford Classification of IgAN. 600 cases of IgAN were identified, of which 568 (94.7 %) were on native kidneys. Male to female ratio was 1.24:1. Patients averaged 32.76 ± 15.12 years old (range 4–89, median 32). Proteinuria and hematuria were observed, respectively in 56.63 and 72.29 % of patients. The association of both these findings occurred in 37.95 % of the cases. Serum creatinine averaged 1.65 ± 0.67 mg/dL (median 1.5 mg/dL) at diagnosis. Segmental sclerosis and mesangial hypercellularity were the main glomerular findings (47.6 and 46.2 %) The commonest combination by Oxford Classification of IgAN, was M0 E0 S0 T0 (22.4 %). Chronic tubulo-interstitial lesions with an extension wider than 25 % of the renal cortex could be identified in 32.2 % of the cases. Tubular atrophy and interstitial fibrosis were more strongly associated with higher 24-h proteinuria and serum creatinine levels. Segmental sclerosis (S1) showed a stronger tendency of association with the presence of tubulo-interstitial lesions (T1 and T2) than other glomerular variables. To the best of our knowledge this is the largest series of IgAN in Brazil. It depicts the main biopsy findings and their possible clinical correlates. Our set of data is comparable to previous reports.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 78%

See 1 more Smart Citation

IgA nephropathy in Brazil: apropos of 600 cases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It is high in the Southeastern States of Minas Gerais (16.15%) and São Paulo (17.8%), and it is low in the States of Para (6.3%), Amazonas (4.3%), and Bahia (5%). 16 , 17 , 18 , 4 , 19…”

Section: Introductionmentioning

confidence: 99%

“…Comparatively, the estimated population self-declared of African heritage is 27.2% and 45.4% in São Paulo and Minas Gerais (IBGE), respectively, where the prevalence of IgAN are 17.8% and 16.15%, respectively. 16 , 17 Conversely, the estimated self-declared African heritage in the State of Para is 71.9% (IBGE), whereas the prevalence of IgAN is 6.3%. 18 However, it is not clear whether these differences are due to the ethnic backgrounds or to different criteria to indicate kidney biopsy.…”

Section: Introductionmentioning

confidence: 99%

IgA Nephropathy in Salvador, Brazil. Clinical and laboratory presentation at diagnosis

Souza

Tavares

Soares³

et al. 2018

J. Bras. Nefrol.

View full text Add to dashboard Cite

show abstract

Renal Outcomes in Brazilian Patients with Immunoglobulin A Nephropathy and Cellular Crescentic Lesions

Neves

Pinheiro

Dias

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

Background and Aim: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy. The Oxford classification was recently updated to include crescents as markers of poor prognosis. The aim of this study was to evaluate the impact of cellular crescents on the prognosis of patients with IgAN in Brazil. Methods: This was a single-centre retrospective analysis of medical records and renal biopsies in patients with IgAN. The renal biopsy findings were classified according to the revised Oxford classification: mesangial hypercellularity, endocapillary hypercellularity (E), segmental glomerulosclerosis (S), tubular atrophy or interstitial fibrosis (T), and crescent formation (C). We evaluated a composite outcome (progression to end-stage renal disease or creatinine doubling). We performed analyses between the patients with crescents in the renal biopsy specimen (C1/C2 group) and those without such crescents (C0 group). Results: We evaluated 111 patients, of whom 72 (65.0%) were women, 80 (72.0%) self-identified as White, 73 (65.6%) were hypertensive, and 95 (85.6%) had haematuria. The distribution of patients according to cellular crescentic lesions was: C0, 80 (72%); C1, 27 (24.4%); C2, 4 (3.6%). The composite outcome was observed in 33 (29.72%) of the 111 patients. In comparison with the C0 group, the C1/C2 group had higher proportions of patients with hypertension (p = 0.04), haematuria (p = 0.03), worse serum creatinine (p = 0.0007), and worse estimated glomerular filtration rate (p = 0.0007). The C1/C2 group also had higher proportions of patients in whom the biopsy specimen was classified as E1 (p = 0.009), S1 (p = 0.001), or T1/T2 (p = 0.03), In addition, the mean follow-up period was shorter in the C1/C2 group (p < 0.0001). Furthermore, the composite outcome was observed in a greater proportion of patients and in a shorter length of time in the C1/C2 group than in the C0 group (p = 0.002 and p = 0.0014, respectively). In a Cox regression analysis, the independent risk factors for the composite outcome had Oxford classifications of S1, T1/T2, and C1/C2. Conclusion: Oxford classification findings of S1, T1/T2, or C1/C2 were independent risk factors for the composite outcome, corroborating previous studies.

show abstract

Nefropatia por IgA: análise histológica e correlação clínico-morfológica em pacientes do Estado de Minas Gerais

Cited by 5 publications

References 28 publications

IgA nephropathy in Brazil: apropos of 600 cases

IgA nephropathy in Brazil: apropos of 600 cases

IgA Nephropathy in Salvador, Brazil. Clinical and laboratory presentation at diagnosis

Renal Outcomes in Brazilian Patients with Immunoglobulin A Nephropathy and Cellular Crescentic Lesions

Contact Info

Product

Resources

About