Nefropatia por IgA em paciente portadora de lúpus eritematoso sistêmico: relato de caso e revisão de literatura

Abstract

Systemic erythematosus lupus (SLE) is a multisystemic autoimmune disease which has nephritis as one of the most striking manifestations. Although it can coexist with other autoimmune diseases, and determine the predisposition to various infectious complications, SLE is rarely described in association with non-lupus nephropathies etiologies. We report the rare association of SLE and primary IgA nephropathy (IgAN), the most frequent primary glomerulopathy in the world population. The patient was diagnosed with SLE due to the occurrence of malar rash, alopecia, pleural effusion, proteinuria, ANA 1: 1280, nuclear fine speckled pattern, and anticardiolipin IgM and 280U/mL. Renal biopsy revealed mesangial hypercellularity with isolated IgA deposits, consistent with primary IgAN. It was treated with antimalarial drug, prednisone and inhibitor of angiotensin converting enzyme, showing good progress. Since they are relatively common diseases, the coexistence of SLE and IgAN may in fact be an uncommon finding for unknown reasons or an underdiagnosed condition. This report focus on the importance of the distinction between the activity of renal disease in SLE and non-SLE nephropathy, especially IgAN, a definition that has important implications on renal prognosis and therapeutic regimens to be adopted in both the short and long terms.

Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors

“…At the time IgAN was reported, IgAN was considered to be a glomerular disease with a good prognosis. Most of the patients were able to achieve a good response after receiving treatment (5). With the deepening of research, IgAN has gradually developed and individual differences are relatively large.…”

Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production

“…SLE is an autoimmune disease which is characterized by B lymphocyte hyperactivity, and B lymphocytes play a crucial role in the pathogenesis of SLE [1,13]. In the present study, mouse B lymphocyte BaF3 was transfected with Sirt1 vector or shRNA against Sirt1 to investigate the potential role of Sirt1 in SLE.…”

“…Systemic lupus erythematosus (SLE), also known as lupus, is an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue in various organs, such as brain, blood, and kidney [1–3]. The exact cause of SLE is still unclear, while hormonal abnormalities, living environment, and genetics identified as main risk factors [4].…”

Paraneoplastic immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in asymptomatic low volume B-cell lymphoma – a case report

“…It is distinguished by IgA-dominant or co-dominant mesangial immune deposits which are visualised using immunohistochemistry [ 2 ]. Secondary IgAN has been associated with various autoimmune conditions (systemic lupus erythematosus [ 3 ], psoriasis [ 4 ], inflammatory bowel disease [ 5 ]), infections (brucellosis [ 6 ], viral hepatitis [ 7 ], tuberculosis [ 8 ]) and malignancies (lymphoma, leukaemia, solid organ tumours) [ 1 ]. Lymphoma-associated IgAN is rare with the majority of reported cases involving aggressive Hodgkin and T-cell lymphomas [ 9 – 11 ].…”