Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement

Korff, Marvin; Lüken, Judith; Schmidt, Judith; Schepmann, Dirk; Goerges, Gunnar; Ritter, Nadine; Disse, Paul; Schreiber, Julian A.; Seebohm, Guiscard; Wünsch, Bernhard

doi:10.1039/d3ob01208e

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob01208e

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Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement

Marvin Korff,

Judith Lüken,

Judith Schmidt

et al.

Abstract: Nucleophilic opening of aryloxiranes with benzylpiperidine and subsequent rearrangement under Mitsunobu conditions led regioselectively to α-aryl-β-piperidinoalcohols and -amines. Amino-ifenprodil and indazole bioisosteres show high GluN2B affinity.

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Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement

Abstract: Nucleophilic opening of aryloxiranes with benzylpiperidine and subsequent rearrangement under Mitsunobu conditions led regioselectively to α-aryl-β-piperidinoalcohols and -amines. Amino-ifenprodil and indazole bioisosteres show high GluN2B affinity.

Cited by 0 publications

References 61 publications

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