Negative association between serum dioxin level and oxidative DNA damage markers in municipal waste incinerator workers

Abstract

With respect to the subjects' serum dioxin level, dioxin did not increase the urinary 8-OH-dG level by oxidative DNA damage, but upregulation of the primary defenses with oxidative damage and/or DNA repair system activity might have occurred.

Levels of metals and organic substances in workers at a hazardous waste incinerator: a follow-up study

“…However, studies concerning internal exposure of workers employed in these facilities are rather scarce. In addition, most of these studies have been carried out in workers at municipal waste incinerators (Hours et al 2003;Leem et al 2003;Kumagai et al 2004;Hu et al 2004;Charbotel et al 2005;Kim et al 2005a;Shih et al 2006b;Yoshida et al 2006), and excepting a survey performed in Germany, in which the levels of a number of metals and organic substances (PCBs, HCB, CLPs, 1-HP, BTEX) were biologically monitored (Angerer et al 1992), the remaining studies were mainly focused on determining PCDD/F concentrations in blood (Kumagai and Koda 2005;Moon et al 2005;Shih et al 2006a, b). Studies concerning the internal exposure of workers at industrial or hazardous waste incinerators are particularly scarce.…”

The health impacts of waste incineration: a systematic review

“…Thirty‐six papers 15,22,27–60 investigated exposure to waste incinerator emissions by measurement of body substances. Upon review, five were found to have been misclassified and were excluded from the analysis.…”

Human biomonitoring to define occupational exposure and health risks in waste incinerator plants

“…The author points out that although the 1,2,3,4,6,7,8-HpCDF marker had an average level six times above that of the general population, this had no significant effect on the total Toxic Equivalent (TEQ) of exposed subjects whose results were compatible with the average levels of the population. A more significant effect is observed in relation to cigarette smoke than for dioxins in terms of oxidation damage of DNA (Yoshida et al, 2006).…”

“…It emerges that both the concentration of dioxin in the serum and the total TEQ are comparable in workers and residents in the vicinity of incinerators (Hu et al, 2004;Yoshida et al, 2006) or inferior in workers (Kim et al, 2005;Moon et al, 2005). Higher levels of contamination can be noticed using hair of workers as indicator compared to the general population (Nakao et al 2005).…”

“…However, the urinary 8-OH-dG shows a significant upward trend with the duration of the activity in the presence of fly ashes . The lymphocytic 8-OH-dG represents the level of oxidative damage only in the blood (a condition of equilibrium between production and repair of oxidative DNA damage) and negatively correlates with the serum dioxin level because it is rapidly affected by the over-regulation induced in the genes that repair the oxidative damage (Yoshida et al, 2006). Other systemic indicators measured (MDA, LPO) did not yield results appropriate to identify the level of oxidative stress of the entire body.…”