Negative Association of the HLA-DQB1<sup>*</sup>02 Allele with Breast Cancer Development among Jordanians

Atoum, Manar; Tanashat, Reem Qasem; Mahmoud, Sameer Al Haj

doi:10.7314/apjcp.2013.14.11.7007

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…[1] In Jordan, breast cancer is the most common malignancy that affects women, accounting for 36.7% of all female cancers and it is the leading cause of cancer deaths among Jordanian women. [2] Risk factors associated with breast cancer include age, family history of breast cancer, ethnicity, weight, using hormone replacement therapy, and low Vitamin D intake.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Atoum

Al-Khatib

2017

Chinese Medical Journal

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Background:Breast cancer is the most common type of cancer among females. Genetic polymorphisms might have a role in carcinogenesis. The aim of this study was to determine whether C to T base substitution within TaqI Vitamin D receptor (VDR) gene (rs731236) in exon 9 was a risk factor among patients with breast cancer.Methods:Peripheral blood was drawn from 122 Jordanian breast cancer patients and 100 healthy Jordanian volunteers in Al-Basheer Hospital during the summer months (from June to November of 2013, 2014, and 2015). DNA was amplified using polymerase chain reaction (PCR), followed by TaqI restriction enzyme digestion. Quantification of serum 25-hydroxy Vitamin D (25[OH]D) level was determined by competitive immunoassay Elecsys.Results:Genotypic frequencies for TaqI TT, Tt, and tt genotypes were 41%, 46%, and 13% for breast cancer compared to 42%, 50%, and 8% for control, respectively. Vitamin D serum level was significantly lower in the breast cancer patients (8.1 ± 0.3 ng/ml) compared to the control group (21.2 ± 0.6 ng/ml; P = 0.001). This study showed an inverse association between 25(OH)D serum level and breast cancer risk (odds ratio [OR], 22.72, 95% confidence interval [CI], 10.06–51.29).Conclusions:An inverse association was found between 25(OH)D serum level and breast cancer risk. Statistical difference was also found between different VDR TaqI genotypes and circulating levels of 25(OH)D among Jordanian females with breast cancer.

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Section: Introductionmentioning

confidence: 99%

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Atoum

Al-Khatib

2017

Chinese Medical Journal

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“…In contrast, the DRB1*11 allele did not show a significant association with this cancer [ 48 ]. Another study in a Jordanian population found no association between carrying the HLA DRB1*11 allele and the risk of developing breast cancer [ 49 ]. Also, Iran authors found a negative association between the alleles, HLA-DRB1*1301 and HLA-DRB1*0101, and breast cancer, while they found positive associations between the allele HLA-DQA1*0301 and this cancer [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Carriage of HLA-DRB111 and 112 alleles and risk factors in patients with breast cancer in Burkina Faso

et al. 2021

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Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.

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“…Genetic studies on cancer are scarce in Jordan and only few studies have screened gene polymorphism in breast cancer. 17 – 20 To our knowledge, no studies have determined the role of ERα PvuII and XbaI polymorphisms in breast cancer susceptibility among Jordanians. Therefore, the aim of this study was to determine the frequency of ERα PvuII and XbaI genotypes and the possible involvement of these polymorphisms in breast cancer susceptibility among Jordanian women with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Reduction in breast cancer susceptibility due to <em>XbaI</em> gene polymorphism of alpha estrogen receptor gene in Jordanians

Atoum

Alzoughool

2017

BCTT

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Breast cancer is a global health concern among women worldwide. Estrogen receptor alpha (ERα) mediates diverse polymorphic effects in breast tissues that may relate to breast cancer susceptibility. The aim of this study was to evaluate the effect of −397 PvuII (T/C) and −351 XbaI (A/G) restriction fragment length polymorphism within intron 1 of ERα, and its effect on breast cancer susceptibility. A total of 156 women who were histopathologically diagnosed with breast cancer and 142 healthy Jordanian women were enrolled in this case–control study. Genomic DNA was extracted from whole peripheral blood, and the desired fragment was amplified using polymerase chain reaction followed by restriction digestion with PvuII and XbaI restriction enzymes. The results showed no significant association between PvuII polymorphism and breast cancer risk. However, a significant association was found between XbaI polymorphism and reduction in breast cancer risk within the “x” allele of heterozygotes (odds ratio [OR] 0.199, 95% confidence interval [CI] 0.09–0.044) and heterozygotes (OR 0.208, 95% CI 0.09–0.047). The combined analysis of PvuII and XbaI polymorphisms revealed a synergistic effect of Pp/Xx and pp/xx genotypes and a significant reduction in breast cancer risk with these genotypes. The results also showed no statistical differences among PvuII or XbaI polymorphisms based on stage, ER, progesterone receptor and expression of hormone receptor such as human epidermal growth factor receptor 2. This case–control study showed that XbaI polymorphism of alpha estrogen gene modified and reduced breast cancer susceptibility among Jordanians.

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Negative Association of the HLA-DQB1^*02 Allele with Breast Cancer Development among Jordanians

Cited by 11 publications

References 26 publications

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Carriage of HLA-DRB111 and 112 alleles and risk factors in patients with breast cancer in Burkina Faso

Reduction in breast cancer susceptibility due to <em>XbaI</em> gene polymorphism of alpha estrogen receptor gene in Jordanians

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Negative Association of the HLA-DQB1*02 Allele with Breast Cancer Development among Jordanians

Cited by 11 publications

References 26 publications

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso

Reduction in breast cancer susceptibility due to <em>XbaI</em> gene polymorphism of alpha estrogen receptor gene in Jordanians

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Negative Association of the HLA-DQB1^*02 Allele with Breast Cancer Development among Jordanians

Carriage of HLA-DRB111 and 112 alleles and risk factors in patients with breast cancer in Burkina Faso