Negative Correlation between the Change in Bone Mineral Density and Serum Osteocalcin in Patients with Hyperthyroidism*

Lee, Myung-Shik; Kim, Seong Yeon; Lee, Myung Chul; Cho, Bo Youn; Lee, Hong Kyu; Koh, Chang-Soon; Min, Hun Ki

doi:10.1210/jcem-70-3-766

Cited by 107 publications

(52 citation statements)

References 17 publications

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“…A osteocalcina em humanos com hipertireoidismo se correlaciona positivamente com o grau da hiperatividade da tireóide e negativamente com as alterações na densidade mineral óssea (LEE et al, 1990). Neste estudo a osteocalcina correlacionou-se com os hormônios tireoidianos, apesar da correlação negativa com a DMO em todos os tempos.…”

Section: Resultsunclassified

Marcadores séricos do metabolismo ósseo no hipertireoidismo felino

et al. 2008

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Section: Resultsunclassified

Marcadores séricos do metabolismo ósseo no hipertireoidismo felino

et al. 2008

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“…The problems which we have to consider are the risk of bone loss and that of atrial fibrillation due to thyrotoxicosis [9][10][11][12][13][14][15][16]. We have no information about bone loss caused by one month delay of ATD therapy, but it should be at a negligible level for the two following reasons: first, thyrotoxic bone disease is a reversible disorder [17][18][19][20][21]; and second, our subjects are young, premenopausal patients.…”

Section: Discussionmentioning

confidence: 99%

Transient Hyperthyroidism after Withdrawal of Antithyroid Drugs in Patients with Graves' Disease

Kubota

Tamai²,

Ohye

et al. 2004

Endocr J

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Abstract. The development of silent thyroiditis in patients with a history of Graves' disease is common, especially in the postpartum period. We describe herein patients with Graves' disease who developed transient hyperthyroidism but not silent thyroiditis after withdrawal of antithyroid drug (ATD). If such patients are diagnosed as recurrence of Graves' disease, they may receive ATD or radioiodine therapy unnecessarily. We investigated the characteristics of these patients to prevent unnecessary therapy. We retrospectively studied 22 patients with Graves' disease who showed transient thyrotoxicosis after withdrawal of ATD. Two of 22 patients were male and the mean ages (± SD) were 33.7 ± 12.6 yr. We observed these patients for 28.5 ± 12.8 (mean ± SD; range 12-53) months after transient thyrotoxicosis, and measured TSH, FT4, and TSH binding inhibitor immunoglobulin in sera. Radioiodine uptake was measured in 6 of them. The radioiodine uptake in the 4 patients was not suppressed (27.5%, 28.0%, 32.7%, 38.1%). These uptake levels indicate that their thyrotoxicosis was not caused by silent thyroiditis. Most of the 22 patients became euthyroid within 6 months. This study suggests a new therapeutic option as follows: in the case of young patients with mild thyrotoxicosis after withdrawal of ATD, physicians should follow them up for one month without medication unless they have unbearable symptoms or complications.

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“…Similar findings were reported in adults. 1,8 The effect of Ca, Vit D supplementation and physical activity needs to be evaluated. In conclusion, our patients, as well as those recently reported, show that Graves' disease can be associated with significant bone demineralization at presentation.…”

Section: Discussionmentioning

confidence: 99%

Osteopenia and Osteoporosis in Two Children with Graves’ Disease

Abdul-Rasoul

Abdulkader

Alhaj

2001

Annals of Saudi Medicine

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The adverse effects of long-standing untreated hyperthyroidism on the bone were first described in 1891 by von Reckling Hausen in a 29-year-old woman who died after five years of hyperthyroidism. The changes described were predominantly those of bone destruction, with increased osteoclastic and osteoblastic activity, especially in cortical bones, causing high turnover osteoporosis and fractures. These changes have been described extensively in adults, but data in children are lacking. We report two cases of Graves' disease in children who had significant osteopenia and osteoporosis at diagnosis. Case 1The patient was an 11-year-old Libyan girl who presented with low back pain after sustaining a fall on her back a day earlier. For the following two weeks, she complained of generalized weakness, shakiness of her hands and a protrusion of her left eye. There had also been a noticeable weight loss over the previous few months. Her past medical history was significant for congenital strabismus, for which she had repeated surgeries that had resulted in significant proptosis of the right eye. She had had speech delay since early childhood, which worsened with the recent tremors and weakness. On physical examination, she looked severely underweight (19 kg, below the 3rd centile), with a heart rate of 130/min., and blood pressure of 122/65 mm Hg. Her hands were warm, with obvious tremors bilaterally, and the eyes were proptotic, especially on the right side. She had significant kyphosis and tenderness on the thoracolumbar spine. A clinical diagnosis of Graves' disease was confirmed by biochemical findings of FT 4 of 69.1 pmol/L and TSH of less than 0.03 mU/L. Radiological examination of her spine revealed compression fracture of the T 6 and T 10 , as well as generalized severe osteopenia. Dual energy x-ray absorptiometry (DEXA) scan showed a significant loss of bone marrow density ( , and was encouraged to undertake active exercise. She showed significant clinical improvement in terms of her weakness and tremors. Compliance was a major problem. Her Ca, phosphorus and alkaline phosphatase were repeated once and were all normal. She was subsequently lost to follow-up for more than a year. A repeat DEXA scan was not done. Case 2A 14-year-old boy presented with neck swelling, polyphagia, weight loss, increased sweating, nervousness and insomnia for a period of three weeks. He had previously been healthy and was not on any medications. His normal diet was rich in calcium (dairy products and vegetables), and he was active and athletic. Physical examination revealed an anxious, thinly built boy (37.7 kg, below the 3rd centile). He had exophthalmus, lid lag and retraction. The thyroid was diffusely enlarged with positive bruit. His hands were warm, sweaty and tremulous. His heart rate was 110/min., and blood pressure was 140/80. He was diagnosed with Graves' disease and was started on methimazole 30 mg daily, as well as propranolol. Thyroid function test showed a thyroxine level of 194 nmol/L, free thyroxine of 76.1 pmol/L and T...

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Negative Correlation between the Change in Bone Mineral Density and Serum Osteocalcin in Patients with Hyperthyroidism*

Cited by 107 publications

References 17 publications

Marcadores séricos do metabolismo ósseo no hipertireoidismo felino

Marcadores séricos do metabolismo ósseo no hipertireoidismo felino

Transient Hyperthyroidism after Withdrawal of Antithyroid Drugs in Patients with Graves' Disease

Osteopenia and Osteoporosis in Two Children with Graves’ Disease

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