This paper presents an innovative approach for error prediction (EP) tailored to near-threshold operations, addressing the energy-efficient requirements of digital circuits in applications such as IoT devices and wearables. The novel EP technique combines the benefits of error prediction and detection, effectively addressing critical issues associated with each method by enabling adaptive prediction capability and voltage scaling. More specifically, the presented EP method requires no modifications to the processor pipeline and mitigates the generation of false-positive errors, ensuring stable operation of the system at high-efficiency points. The effectiveness of this strategy is demonstrated through its implementation in a near-threshold 32-bit microprocessor system with a modest 5.82% area overhead. Silicon measurements validate the adaptive EP system from 0.59 to 0.66 V (4–32 MHz) and confirm its removal of all voltage margins. Here, the EP technique reduces the energy consumption by 18.6–25.1% with respect to the signoff margins and it allows the system to operate without energy overhead compared to its ideal non-margined critical operation point, with less than a 5% throughput loss.