2019
DOI: 10.5214/ans.0972.7531.260106
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Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism

Abstract: Background: Negative geotaxis (NG) is an important parameter, commonly used in study of different CNS diseases and neurodevelopmental disorders. Neurobehavioural change following brain injury was easily identified by negative geotaxis. Purpose: Although NG is evaluated in the settings of ASD, most of the studies are conducted for short duration (1-3 day) and the overall trend of acquisition of NG is not evaluated. In this context, we wanted to evaluate the trend of acquisition of negative geotaxis as a behavio… Show more

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Cited by 47 publications
(36 citation statements)
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“…Negative geotaxis is used to evaluate vestibular function and motor performance of cerebellar development and function. 27 Increase in the time taken to reorient on the slanted plane was found in the autistic group. Reorientation time was restored in treatment groups from 15 PND onwards.…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…Negative geotaxis is used to evaluate vestibular function and motor performance of cerebellar development and function. 27 Increase in the time taken to reorient on the slanted plane was found in the autistic group. Reorientation time was restored in treatment groups from 15 PND onwards.…”
Section: Discussionmentioning
confidence: 90%
“…Inactivity to rotate 180° to such an extent that the head was mounted along the slope was noted with a limit of 30 seconds for each trial. 27…”
Section: Negative Geotaxismentioning
confidence: 99%
“…Histopathology results of cerebellum reveals damage and apoptosis of molecular layer, granular layer seen in the autistic group. 28 Treatment with lactobacillus strains reveals mild degeneration, few necrotic cells reported in L. Plantarum and L. Bulagricus. Cerebellum become normal is seen L. Acidophilus and L. Casei and Multilactobacillus strain treatment groups.…”
Section: Discussionmentioning
confidence: 97%
“…In autistic group increase time to reorient on the inclined plane. 19,28,29 . Reorientation time was decreased by lactobacilli.…”
Section: Discussionmentioning
confidence: 99%
“…Two tests were selected specifically for assessing the motor and coordination abilities of young rats, the righting reflex, and the negative geotaxis [ 86 , 87 , 88 ]. No training was required, and animals were asked to perform each test only one time a day to avoid fatigue.…”
Section: Methodsmentioning
confidence: 99%