Abstract. In an earlier work, we investigated some consequences of the existence of a Kähler metric of negative holomorphic sectional curvature on a projective manifold. In the present work, we extend our results to the case of semi-negative (i.e., non-positive) holomorphic sectional curvature. In doing so, we define a new invariant that records the largest codimension of maximal subspaces in the tangent spaces on which the holomorphic sectional curvature vanishes. Using this invariant, we establish lower bounds for the nef dimension and, under certain additional assumptions, for the Kodaira dimension of the manifold. In dimension two, a precise structure theorem is obtained.