Negative In Vivo Results Despite Promising In Vitro Data With a Coated Compliant Electrospun Polyurethane Vascular Graft

Fortin, William; Maire, Marion; Héon, Hélène; Ajji, Abdellah; Therasse, Eric; Lerouge, Sophie

doi:10.1016/j.jss.2022.05.032

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…In vitro, the conduits significantly reduced protein absorption and enhanced the adhesion, proliferation, and retention of endothelial cells seeded on the surface. Therefore, an end-to-end common carotid bypass was performed in 10 sheep, although there was no improvement in endothelialization compared with the controls [ 157 ].…”

Section: Regulatory Aspectsmentioning

confidence: 99%

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Uhljar

Ambrus

2023

Pharmaceutics

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Electrospinning is the simplest and most widely used technology for producing ultra-thin fibers. During electrospinning, the high voltage causes a thin jet to be launched from the liquid polymer and then deposited onto the grounded collector. Depending on the type of the fluid, solution and melt electrospinning are distinguished. The morphology and physicochemical properties of the produced fibers depend on many factors, which can be categorized into three groups: process parameters, material properties, and ambient parameters. In the biomedical field, electrospun nanofibers have a wide variety of applications ranging from medication delivery systems to tissue engineering scaffolds and soft electronics. Many of these showed promising results for potential use as medical devices in the future. Medical devices are used to cure, prevent, or diagnose diseases without the presence of any active pharmaceutical ingredients. The regulation of conventional medical devices is strict and carefully controlled; however, it is not yet properly defined in the case of nanotechnology-made devices. This review is divided into two parts. The first part provides an overview on electrospinning through several examples, while the second part focuses on developments in the field of electrospun medical devices. Additionally, the relevant regulatory framework is summarized at the end of this paper.

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Section: Regulatory Aspectsmentioning

confidence: 99%

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Uhljar

Ambrus

2023

Pharmaceutics

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“…Кроме того, для снижения ХП сосудистых протезов с высокой пористостью в качестве источника фибрина используют фибриновый клей [9], сшитые гидрогели на основе белков (альбумина, коллагена, желатина и др. [10][11][12][13]), хондроитин сульфат [14], фиброин шелка [15], альгинат натрия [16], производные декстранов [17] и хитозан [18].…”

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Technique for reducing the surgical porosity of small-diameter vascular grafts

Nemets,

Khairullina,

Belov

et al. 2023

RJTAO

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High surgical porosity (SP) is one of the causes of significant blood loss, as well as hematoma formation. So, reducing the SP of small-diameter vascular grafts (VGs) is a crucial task.The objective of this work was to develop a technology for the formation of polycaprolactone (PCL)-based small-diameter VGs with a bioactive coating with reduced SP.Materials and methods. Porous VGs with an inner diameter of 3 mm were fabricated by electrospinning from 5% PCL solution with addition of 5–30% gelatin (PCL/G) on an NANON-01A unit (MECC CO, Japan). Bioactive coating was applied by sequential incubation of VGs in solutions of bovine serum albumin, heparin and platelet lysate with fixation in a glutaric aldehyde solution. The surface structure and mechanical properties of the samples were investigated. Functional properties of the bioactive VGs were evaluated in relation to their interaction with cell cultures in vitro.Results. It was found that introduction of gelatin into the working solution reduces SP from 30.4 ± 1.5 mL/(cm2 ·min) to 2.8 ± 0.5 ml/(cm2 ·min). It was shown that at a PCL/gelatin ratio of 9 : 1, the outer and inner sides of the bioactive VGs samples are characterized by surface uniformity (no defects), mechanical properties close to blood vessels of the same diameter (Young’s modulus 6.7 ± 2.1 MPa, tensile strength 26.7 ± 4.9 N and elongation to break 423 ± 80%) and ability to support adhesion and proliferation of human umbilical vein endothelial cell line, EA.hy926.Conclusion. Introduction of 10% gelatin content (by the polymer weight) into PCL solution reduces the SP of small-diameter VGs, leads to uniformity in their inner and outer surface, improvement in their mechanical properties without reducing their ability to support adhesion and proliferation of vascular endothelial cells.

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Shore hardness of bulk polyurethane affects the properties of nanofibrous materials differently

Łopianiak,

Butruk-Raszeja,

Wojasiński

2025

Journal of the Mechanical Behavior of Biomedical Materials

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Negative In Vivo Results Despite Promising In Vitro Data With a Coated Compliant Electrospun Polyurethane Vascular Graft

Cited by 4 publications

References 57 publications

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Technique for reducing the surgical porosity of small-diameter vascular grafts

Shore hardness of bulk polyurethane affects the properties of nanofibrous materials differently

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