Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy

Li, Xinxing; Hao, Lu; Xu, Kai; Wang, Haolu; Liang, Xiaowen; Hu, Zhiqian

doi:10.1186/s12885-017-3222-8

Cited by 24 publications

(20 citation statements)

References 17 publications

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“…Recently, LN count drew the attention to assess their impact on the cancer recurrence and OS [11]. Moreover, many researchers have shown the prognostic role of examined (dissected) LNs (ELNs) [12-14], positive (metastatic) LNs (PLNs) [15], negative LNs (NLNs), and LN ratio (LNR) in different cancer types including esophageal, thyroid, cervical, and lung cancers [16]. NLN count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer [12].…”

Section: Introductionmentioning

confidence: 99%

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

et al. 2020

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Background: Prostate cancer (PCa) is the third leading cause of death from cancer in the United States. We aimed to disclose the prognostic values of examined (dissected) lymph node (ELN), negative lymph node (NLN), and positive (metastatic) lymph node (PLN) counts and lymph node (LNs) ratio in PCa patients. Methods: We extracted data of PCa patients diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) program. We included patients with a histologically confirmed diagnosis having at least one ELN and with the PCa as the primary tumor only. Results: We have included 96,064 patients. Multivariable Cox proportional hazards regression models disclosed that patients having more ELNs were associated with better survival. However, we demonstrated that patients having more PLNs were associated with worse survival. Additionally, older age, unmarried patients, with Gleason's score of 8-10, T4 and M1 stages and those who received chemotherapy and/ or radiation but did not receive surgery were significantly associated with worse PCa survival. Conclusions: We have disclosed several independent predictors affecting PCa patients including age, marital status, Gleason's score, T and N stages, having received therapy, surgery, and ELN and PLN counts. Moreover, we demonstrated that patients with lower ELN and higher PLN counts were a high-risk group. We strongly recommend adding the ELN and/or PLN counts into consideration during patient staging/treatment.

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Section: Introductionmentioning

confidence: 99%

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

et al. 2020

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“…Rectal cancer (RC), one of the most commonly diagnosed malignant tumors, is a crucial threat imperiling human health worldwide. 1 2016 cancer statistics report indicated approximately 39220 new RC cases in the United States and estimated incidence of 11 per 100000 people in the developing countries. 2 3 Despite of great improvement in early diagnosis, operative treatment, adjuvant therapies (such as chemotherapy, radiotherapy and hormonotherapy) and integrated patients' care, the prognosis of RC patients remains far from satisfaction.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer

2018

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PurposeTo investigate the association of cancer stem-cell markers [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and Nanog homebox (NANOG)] expression with clinicopathological properties and overall survival (OS) in operative rectal cancer (RC) patients receiving adjuvant therapy.Materials and Methods153 patients with primary RC receiving surgery were enrolled. Tumor tissue and paired adjacent normal tissue sample were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunofluorescent staining. The median follow-up duration was 5.2 years, and the last follow-up date was August 2016.ResultsTumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue. OCT4 expression was positively correlated with pathological grade (R=0.185, p=0.022), tumor size (R=0.224, p=0.005), and N stage (R=0.170, p=0.036). NANOG expression was positively associated with tumor size (R=0.169, p=0.036). Kaplan-Meier suggested that OCT4+ was associated with worse OS compared with OCT4− (p<0.001), while no association of SOX2 (p=0.121) and NANOG expressions (p=0.195) with OS was uncovered. Compared with one or no positive marker, at least two positive markers were associated with shorter OS (p<0.001), while all three positive markers were correlated with worse OS compared with two or less positive markers (p<0.001). Multivariate Cox's analysis revealed that OCT4+ (p<0.001) and N stage (p=0.046) were independent factors for shorter OS.ConclusionTumor tissue OCT4 expression was correlated with poor differentiation, tumor size, and N stage, and it can serve as an independent prognostic biomarker in operative patients with RC receiving adjuvant therapy.

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“…However, eight negative LNs is not a minimum number according to our study. We used X‐Tile model to identify the appropriate number which have been applied by other studies (Huang et al, ; Li et al, ; Spillane, Haydu, McMillan, Stretch, & Thompson, ). Our results demonstrated that the optimal cut‐off value for negative LNs dissection was five in patients with high‐risk group, and patients with >5 negative LNs dissection had a significantly higher CSS than those with ≤5 negative LNs dissection.…”

Section: Discussionmentioning

confidence: 99%

The appropriate number of negative lymph nodes dissection for nonmetastatic penile cancer

Wei

et al. 2018

Andrologia

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Negative lymph nodes status has been attached more attention as a prognostic indicator for nonmetastatic penile cancer. We aimed to identify the appropriate number of negative lymph nodes dissection for nonmetastatic penile cancer using the Surveillance, Epidemiology and End Results database. A total of 1,470 nonmetastatic patients with penile squamous cell carcinoma were identified during 2004 and 2013. All patients were categorised according to different risk levels and lymphadenectomy. Univariate and multivariate Cox regression analyses were performed to evaluate the relationship between prognostic risk factors and cancer‐specific survival. The optimal cut‐off value of negative lymph nodes dissection was determined using the X‐Tile program. A total of 1,470 patients were categorised into low‐ (pT1G1), intermediate‐ (pT1G2) or high‐risk (pT1G3 and all higher stages) groups. In multivariate Cox analysis, lymphadenectomy improved the cancer‐specific survival for patients in high‐risk group (p = 0.014). Further, the optimal cut‐off value of negative lymph nodes dissection for high‐risk patients was 5 and patients with >5 negative lymph nodes had a higher cancer‐specific survival (χ2 = 9.3676, p < 0.05). Therefore, lymphadenectomy improved survival for high‐risk penile cancer and the removal of more than five negative lymph nodes was correlated with higher cancer‐specific survival for high‐risk patients who underwent lymphadenectomy.

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Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy

Cited by 24 publications

References 17 publications

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer

The appropriate number of negative lymph nodes dissection for nonmetastatic penile cancer

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