Negative myocardial technetium-99m pyrophosphate scintigraphy in amyloid heart disease associated with type AA systemic amyloidosis

Leinonen, Hannu; Tötterman, Karl-Johan; Korppi-Tommola, T; Korhola, O

doi:10.1016/0002-9149(84)90481-8

Cited by 23 publications

(10 citation statements)

References 5 publications

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“…Various workers have found a positive up take of Tc-99m pyrophosphate in patients with cardiac amyloidosis, especially those with advanced disease [10,[19][20][21], However, others have not found this to be a useful test [22,23]. It is possible that, apart from the severity of amyloid infiltration, the underly ing type of amyloid protein may affect the binding of pyrophosphate in different pa tients.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Amyloidosis Presenting as Ischemic Heart Disease

Narang

Chopra²,

Wasir³

1993

Cardiology

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Section: Discussionmentioning

confidence: 99%

Cardiac Amyloidosis Presenting as Ischemic Heart Disease

Narang

Chopra²,

Wasir³

1993

Cardiology

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“…Scan positivity has been related to ventricular wall thickness and to the amount of amyloid in the myocardium [15,26]. It has also been suggested that amyloid fibril composition might affect myocardial technetium-99m-pyrophosphate uptake [17,26]. Technetium-99m-pyrophosphate scintigraphy was found to be a sensitive indicator in advanced amyloidosis derived from immunoglobulin light chains as seen in primary or myeloma associated amyloidosis (AL-type amyloidosis).…”

Section: Discussionmentioning

confidence: 99%

“…First pass images were obtained in LAO 40 ° projection immediately after injection and planar scans were acquired 4-6h and 24h after injection (LAO 45 °, LAO 70 ° anterior views of the heart and posterior views of the kidney region) [15,17]. A total of 800 kcounts were acquired with a digital gamma camera (Sopha Medical, Frankfurt, FRG with a matrix 256 x 256 pixel) equipped with a parallel-hole low energy collimator.…”

Section: Methodsmentioning

confidence: 99%

“…While some authors believe that the scan with technetium-99 m-pyrophosphate is a sensitive and specific method for the detection of amyloid deposits [14,15] others do not share this opinion. [17,18]. In this report we present our results of combined static and first-pass scintigraphy with technetium-99 m-pyrophosphate in 7 patients with systemic amyloidosis and cardiac involvement.…”

Section: Introductionmentioning

confidence: 95%

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Is technetium-99 m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis?

et al. 1990

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Amyloidosis is a systemic disease frequently involving the myocardium and leading to functional disturbances of the heart. Amyloidosis can mimic other cardiac diseases. A conclusive clinical diagnosis of cardiac involvement can only be made by a combination of different diagnostic methods. In 7 patients with myocardial amyloidosis we used a combined first-pass and static scintigraphy with technetium-99 m-pyrophosphate. There was only insignificant myocardial uptake of the tracer. The first-pass studies however revealed reduced systolic function in 4/7 patients and impaired diastolic function in 6/7 patients. Therefore, although cardiac amyloid could not be demonstrated in the static scintigraphy due to amyloid fibril amount and composition, myocardial functional abnormalities were seen in the first-pass study.

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“…Many case reports were published in the early 1980s and later [30,[38][39][40][41][42][43][44][45][46][47][48][49][50][51]. In 1982, Wizenberg et al investigated a group of ten patients with tissue-proven amyloidosis using 99m Tc-PYP (only two had histologically proven cardiac amyloidosis).…”

Section: Amyloid Deposits 99m Tc-aprotininmentioning

confidence: 99%

Nuclear imaging in cardiac amyloidosis

Glaudemans

Slart

Zeebregts

et al. 2009

Eur J Nucl Med Mol Imaging

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Amyloidosis is a disease characterized by depositions of amyloid in organs and tissues. It can be localized (in just one organ) or systemic. Cardiac amyloidosis is a debilitating disease and can lead to arrhythmias, deterioration of heart function and even sudden death. We reviewed PubMed/Medline, without time constraints, on the different nuclear imaging modalities that are used to visualize myocardial amyloid involvement. Several SPECT tracers have been used for this purpose. The results with these tracers in the evaluation of myocardial amyloidosis and their mechanisms of action are described. Most clinical evidence was found for the use of 123 I-MIBG. Myocardial defects in MIBG activity seem to correlate well with impaired cardiac sympathetic nerve endings due to amyloid deposits. 123 I-MIBG is an attractive option for objective evaluation of cardiac sympathetic level and may play an important role in the indirect measurement of the effect of amyloid myocardial infiltration. Other, less sensitive, options are 99m Tc-aprotinin for imaging amyloid deposits and perhaps 99m Tc-labelled phosphate derivatives, especially in the differential diagnosis of the aetiology of cardiac amyloidosis. PET tracers, despite the advantage of absolute quantification and higher resolution, are not yet well evaluated for the study of cardiac amyloidosis. Because of these advantages, there is still the need for further research in this field.

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Negative myocardial technetium-99m pyrophosphate scintigraphy in amyloid heart disease associated with type AA systemic amyloidosis

Cited by 23 publications

References 5 publications

Cardiac Amyloidosis Presenting as Ischemic Heart Disease

Cardiac Amyloidosis Presenting as Ischemic Heart Disease

Is technetium-99 m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis?

Nuclear imaging in cardiac amyloidosis

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