Negative perception of socioeconomic status with depressive mood down-regulates expression of <i>PPBP</i> and <i>SLC1A7</i> genes in peripheral blood leukocytes

Fujita, Kinuyo; Kuwano, Yuki; Saijo, Saki; Nishikawa, Tatsuya; Nishida, Kensei; Rokutan, Kazuhito

doi:10.1080/23311908.2017.1338825

“…Young et al discovered that DISC1 gene plays a vital role in post-traumatic stress disorder (PTSD) severity of US military veterans [11]. In another research, Fujita K, et al revealed that SLC1A7 gene expression in peripheral blood leukocytes is responsible for the association between socioeconomic status and depressive mood in healthy adults [12]. We speculated that SLC1A7 and DISC1 may work in regulating the symptoms of GD such as nervousness, irritability and irritability.…”

Section: Discussionmentioning

confidence: 86%

Screening of Graves' Disease Susceptibility Genes by Whole Exome Sequencing in a Three-generation Family

Hu

¹

,

Li²,

Li

³

et al. 2020

Preprint

0

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Background: Graves’ disease(GD) has a tendency for familial aggregation, but it is uncommon to occur in more than two generations. Little is known about susceptibility genes for GD in the three-generation family.Methods: DNA were extracted from three-generation familial GD patient with a strong genetic background in a Chinese Han population. We utilize the Whole Exome Sequencing(WES) to screen and the Sanger sequencing confirmed potential disease-causing genes.Results:In this case study, there are five patients with Graves’ disease(GD) from a three-generation family. We firstly revealed the SNVs of MAP7D2(c. 452C>T: p. A151V), SLC1A7(c. 1204C>T: p. R402C), TRAF3IP3(c. 209A>T: p. N70I), PTPRB(c. 3472A>G: p. S1158G), PIK3R3(c. 121C>T: p. P41S), DISC1(c. 1591G>C: p. G531R) were associated with the familial GD. The Sanger sequencing confirmed these variations and more importantly is that the PolyPhen-2 score showed that the variants in TRAF3IP3, PTPRB, PIK3R3 are more likely to change protein functions.Conclusion: The MAP7D2, SLC1A7, TRAF3IP3, PTPRB, PIK3R3, DISC1 may be the candidate susceptibility genes for familial GD from a three generations family.

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“…Young et al discovered that DISC1 gene played a vital role in post-traumatic stress disorder (PTSD) severity of US military veterans [14]. In another research, Fujita K, et al revealed that SLC1A7 gene expression in peripheral blood leukocytes was responsible for the association between socioeconomic status and depressive mood in healthy adults [15]. We speculated that SLC1A7 and DISC1 are involved in regulating the symptoms of GD such as nervousness and irritability.…”

Section: Discussionmentioning

confidence: 90%

Screening of Graves' Disease Susceptibility Genes by Whole Exome Sequencing in a Three-generation Family

Hu

¹

,

Li²,

Li

³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Graves’ disease(GD) has a tendency for familial aggregation, but it is uncommon to occur in more than two generations. However, little is known about susceptibility genes for GD in the three-generation family. Methods DNA were extracted from three-generation familial GD patient with a strong genetic background in a Chinese Han population. The Whole Exome Sequencing (WES) was utilized to screen the genome for SNVs associated with GD and the Sanger Sequencing was used to confirm the potential disease-causing genes. Results In the case study, there were five patients with Graves’ disease(GD) from a three-generation family. The SNVs of MAP7D2(c. 452C > T: p. A151V), SLC1A7(c. 1204C > T: p. R402C), TRAF3IP3(c. 209A > T: p. N70I), PTPRB(c. 3472A > G: p. S1158G), PIK3R3(c. 121C > T: p. P41S), DISC1(c. 1591G > C: p. G531R) were found to be associated with the familial GD and the Sanger sequencing had confirmed these variations. Furthermore, PolyPhen-2 score showed that the variants in TRAF3IP3, PTPRB, PIK3R3 are more likely to change protein functions. Conclusion The MAP7D2, SLC1A7, TRAF3IP3, PTPRB, PIK3R3, DISC1 may be the candidate susceptibility genes for familial GD from a three generations family.

show abstract

“…Young et al discovered that DISC1 gene played a vital role in post-traumatic stress disorder (PTSD) severity of US military veterans [14]. In another research, Fujita K, et al revealed that SLC1A7 gene expression in peripheral blood leukocytes was responsible for the association between socioeconomic status and depressive mood in healthy adults [15]. We speculated that SLC1A7 and DISC1 are involved in regulating the symptoms of GD such as nervousness and irritability The protein encoded by PTPRB belongs to the family of protein tyrosine phosphatases (PTP).…”

Section: Discussionmentioning

confidence: 99%

Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family

Hu

¹

,

Li

²

,

Li

³

et al. 2021

View full text Add to dashboard Cite

Background Graves’ disease(GD) has a tendency for familial aggregation, but it is uncommon to occur in more than two generations. However, little is known about susceptibility genes for GD in the three-generation family. Methods DNA were extracted from three-generation familial GD patient with a strong genetic background in a Chinese Han population. The Whole Exome Sequencing (WES) was utilized to screen the genome for SNVs associated with GD and the Sanger Sequencing was used to confirm the potential disease-causing genes. Results In the case study, there were five patients with Graves’ disease(GD) from a three-generation family. The SNVs of MAP7D2(c. 452C > T: p. A151V), SLC1A7(c. 1204C > T: p. R402C), TRAF3IP3(c. 209A > T: p. N70I), PTPRB(c. 3472A > G: p. S1158G), PIK3R3(c. 121C > T: p. P41S), DISC1(c. 1591G > C: p. G531R) were found to be associated with the familial GD and the Sanger sequencing had confirmed these variations. Furthermore, PolyPhen-2 score showed that the variants in TRAF3IP3, PTPRB, PIK3R3 are more likely to change protein functions. Conclusion The MAP7D2, SLC1A7, TRAF3IP3, PTPRB, PIK3R3, DISC1 may be the candidate susceptibility genes for familial GD from a three generations family.

show abstract

Negative perception of socioeconomic status with depressive mood down-regulates expression of PPBP and SLC1A7 genes in peripheral blood leukocytes

Cited by 8 publications

References 51 publications

Screening of Graves' Disease Susceptibility Genes by Whole Exome Sequencing in a Three-generation Family

Screening of Graves' Disease Susceptibility Genes by Whole Exome Sequencing in a Three-generation Family

Screening of Graves' Disease Susceptibility Genes by Whole Exome Sequencing in a Three-generation Family

Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family

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